SBIR TOPIC 431 - MOBILE ORAL-CANCER SCREENING AND TREATMENT (MOST) SYSTEM FOR LOW-RESOURCE SETTINGS
SBIR 主题 431 - 适用于资源匮乏环境的移动口腔癌筛查和治疗(大多数)系统
基本信息
- 批准号:10706238
- 负责人:
- 金额:$ 39.99万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-09-15 至 2023-09-14
- 项目状态:已结题
- 来源:
- 关键词:AddressDeveloped CountriesDiagnosisDisease ProgressionEarly DiagnosisFDA approvedImageLesionLightMalignant - descriptorMalignant NeoplasmsModalityMorbidity - disease rateMusOralOral StageOropharyngeal Squamous Cell CarcinomaPUVA PhotochemotherapyPatientsPerformancePhotochemistryResearchResource-limited settingScreening for Oral CancerSmall Business Innovation Research GrantStage at DiagnosisSurvival RateSystemTechnologyTimeUnited States National Institutes of HealthXenograft Modelbasecosthigh riskhigh risk populationlow and middle-income countriesmalignant mouth neoplasmmortalitypremalignantrural areasubcutaneoussuccess
项目摘要
Oral and oropharyngeal squamous cell carcinoma (OSCC) together rank as the sixth most common cancer worldwide, it is the most common cancer in some low- and middle- income countries (LMICs). The poor survival rate in LMICs and rural regions in developed countries is mainly due to late diagnosis and the resultant progression of disease to an advanced stage at diagnosis. Motivated by the successes in the two different NIH UH2/UH3 projects for detecting and treating pre- and early oral cancers, Light Research Inc (LRI) proposes to develop and commercialize a new integrated mobile oral-cancer screening and treatment (MOST) system, optimized for low-resource settings (LRS). It combines dual-modal oral cancer screening technology and photochemistry-based, FDA approved photodynamic therapy (PDT) modality. We will first develop the MOST system (Aim 1) and then demonstrate the imaging and treatment performance of MOST system with murine subcutaneous xenograft model (Aim 2). This project is significant because early diagnosis of oral cancers and timely treatment can reduce disease progression, reduce morbidity and mortality, and cut costs. It addresses the major barrier to screen high-risk population and treat patients with high risk oral premalignant and malignant lesions (OPML) and early-stage oral cancer in LRS.
口腔和口咽鳞状细胞癌(OSCC)一起列为全球第六大常见癌症,它是一些低收入和中等收入国家(LMIC)最常见的癌症。低收入国家和发达国家农村地区的存活率低,主要是由于诊断晚,导致疾病在诊断时进展到晚期。 受两个不同的NIH UH 2/UH 3项目在检测和治疗前和早期口腔癌方面取得的成功的激励,Light Research Inc(LRI)提出开发并商业化一种新的集成移动的口腔癌筛查和治疗(MOST)系统,该系统针对低资源环境(LRS)进行了优化。它结合了双模式口腔癌筛查技术和基于光化学的FDA批准的光动力治疗(PDT)模式。我们将首先开发MOST系统(目标1),然后用小鼠皮下异种移植模型证明MOST系统的成像和治疗性能(目标2)。该项目意义重大,因为口腔癌的早期诊断和及时治疗可以减少疾病进展,降低发病率和死亡率,并降低成本。它解决了在LRS中筛查高危人群和治疗高危口腔癌前病变和恶性病变(OPML)和早期口腔癌患者的主要障碍。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
RONGGUANG LIANG其他文献
RONGGUANG LIANG的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
相似海外基金
Optimizing HIV Care in Less Developed Countries
优化欠发达国家的艾滋病毒护理
- 批准号:
10580906 - 财政年份:2023
- 资助金额:
$ 39.99万 - 项目类别:
Trade standards compliance in agricultural and food trade, differences between markets of developing and developed countries - a comparative study of China and the U.S.
农产品和食品贸易中的贸易标准合规情况、发展中国家与发达国家市场的差异——中美比较研究
- 批准号:
22K14960 - 财政年份:2022
- 资助金额:
$ 39.99万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
Conceptualizing and Implementing a Rights-Based Approach to Address Food Insecurity at City Level in Developed Countries - A Pilot Trial in York
构思和实施基于权利的方法来解决发达国家城市一级的粮食不安全问题——在约克的试点试验
- 批准号:
2750056 - 财政年份:2022
- 资助金额:
$ 39.99万 - 项目类别:
Studentship
The effects of the perception of China threat on economic policies in developed countries: the case of the US Congress
中国威胁认知对发达国家经济政策的影响:以美国国会为例
- 批准号:
22K01384 - 财政年份:2022
- 资助金额:
$ 39.99万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Dynamic macroeconomic analysis of innovation in developed countries and technology transfer to developing countries
发达国家创新和向发展中国家转让技术的动态宏观经济分析
- 批准号:
20K01561 - 财政年份:2020
- 资助金额:
$ 39.99万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Potential and challenges of health promotion activities in ECD in least developed countries - a study based on the human security theory
最不发达国家儿童早期发展健康促进活动的潜力和挑战——基于人类安全理论的研究
- 批准号:
19K02582 - 财政年份:2019
- 资助金额:
$ 39.99万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Evaluation of Taktfahrplan in developed countries with improved timetable and necessity and possibility of introduction in Japan
对发达国家 Taktfahrplan 的评估以及改进的时间表以及在日本引入的必要性和可能性
- 批准号:
19H02258 - 财政年份:2019
- 资助金额:
$ 39.99万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Application of systems approach to international migration through studying abroad in Malaysia: Focusing on migrants from least developed countries
系统方法在马来西亚留学国际移民中的应用:关注最不发达国家的移民
- 批准号:
19K14124 - 财政年份:2019
- 资助金额:
$ 39.99万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
A Comparative Study of Cultural and Social Transformation in Developed Countries: Focusing on Northern Europe and Japan
发达国家文化社会转型比较研究:以北欧和日本为中心
- 批准号:
19F19729 - 财政年份:2019
- 资助金额:
$ 39.99万 - 项目类别:
Grant-in-Aid for JSPS Fellows
International Comparison between Euro-American rice for Washoku and Japanese Commercial Rice: Comparison Limited to Developed Countries, Italy, the United States, and Japan
欧美和食大米与日本商品米的国际比较:仅限于发达国家、意大利、美国、日本
- 批准号:
18K05873 - 财政年份:2018
- 资助金额:
$ 39.99万 - 项目类别:
Grant-in-Aid for Scientific Research (C)