Development of Multilayer Strip Ion Chamber Device for the Measurement of Proton FLASH-Radiotherapy

用于测量质子闪光放射治疗的多层条形电离室装置的开发

• 批准号: 10714482
• 负责人: HAO JIANG
• 金额: $ 39.62万
• 依托单位: TETRAIMAGING, LLC
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-16 至 2023-09-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10714482
• 关键词: Algorithmic Software; Characteristics; Charge; Collection; Computer software; Cyclotrons; Development; Devices; Dose; Dose-Rate; Genetic Recombination; Human body; Ions; Measurement; Measures; Modality; Normal tissue morphology; Positioning Attribute; Protons; Radiation Dose Unit; Radiation therapy; Spottings; Synchrocyclotron; Systems Development; Systems Integration; Toxic effect; Validation; cell killing; design; improved; neoplastic cell; proton beam; quality assurance; research study; tool

Ultra-high dose rate radiotherapy or FLASH-RT, has shown the potential to drastically reduce the normal tissue toxicity without compromising tumor cell killing. Proton is the only treatment modality that can treat deep seated target in human body with FLASH-RT. With radiation dose delivered in less than a second, an ultra-fast quality assurance (QA) device is needed to verify the delivery of FLASH-RT. We will develop a multilayer strip ion chamber (MLSIC) device can measure the characteristics of a proton flash beam spot-by-spot including spot position and profile, energy, and absolute dose. The MLSIC device can be used for development, commissioning and QA of proton flash-beams. To develop the MLSIC and achieve the unmet need of QA device for flash-RT, we will perform the research studies to achieve following objectives: 1) Design, optimization, and characterization of a MLSIC device for proton FLASH-RT QA in a synchrocyclotron and an isochronous cyclotron; and 2) Development of proton beam QA algorithm and software for the MLSIC.

超高剂量速率放疗或闪存-RT表明有可能大大降低正常组织毒性而不会损害肿瘤细胞。质子是唯一可以使用Flash-RT治疗人体中深座的治疗方式。随着辐射剂量在不到一秒钟的时间内传递，需要使用超快速保证（QA）设备来验证闪存RT的交付。我们将开发一个多层带离子室（MLSIC）设备可以测量质子闪光灯点斑点的特征，包括点位置和轮廓，能量，能量和绝对剂量。 MLSIC设备可用于开发，调试和质量质子闪光灯。为了开发MLSIC并达到QA设备对Flash-RT的未满足需求，我们将执行研究以实现以下目标：1）在同步性clotron中的质子Flash-RT QA的MLSIC设备设计，优化和表征，以及同步性环节； 2）开发用于MLSIC的质子束质量质量质量算法和软件。