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TO IDENTIFY NOVEL ADJUVANT CANDIDATES THAT CAN BE USED TO AUGMENT THE EFFICACY OF HUMAN VACCINES.

TO IDENTIFY NOVEL ADJUVANT CANDIDATES THAT CAN BE USED TO AUGMENT THE EFFICACY OF HUMAN VACCINES.
确定可用于增强人类疫苗功效的新型佐剂候选物。
批准号：
10706867
负责人：
DENNIS CARSON
金额：
$40.0万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
项目状态：
已结题
起止时间：
2019-09-30 至 2024-09-29
来源：
https://reporter.nih.gov/project-details/10706867
关键词：
Adaptive Immune SystemAdjuvantAntigensAwardB-LymphocytesCellsContractorFormulationHumanImmunologic MemoryInnate Immune SystemLigandsLiposomesResearchT-LymphocyteTLR4 geneVaccinesnovelpathogenresponsescale upsmall molecule

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中文摘要
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英文摘要
The contractor will identify novel adjuvant candidates that can be used to augment the efficacy of human vaccines. Research performed under this award will contribute to the pipeline of new adjuvant leads that either: (a) exploit the natural capacity of the innate immune system to initiate and sustain effective T and B cell responses and to induce long term immune memory, or (b) act directly on cells of the adaptive immune system to enhance their response to pathogen-derived antigens.
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Tetrahydrothieno[2,3-c]pyridines as Vaccine Co-adjuvants
Discovery of agents that induce exosomes with adjuvant activity
Discovery of agents that induce exosomes with adjuvant activity
Discovery of agents that induce exosomes with adjuvant activity
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