TO IDENTIFY NOVEL ADJUVANT CANDIDATES THAT CAN BE USED TO AUGMENT THE EFFICACY OF HUMAN VACCINES.

确定可用于增强人类疫苗功效的新型佐剂候选物。

• 批准号: 10706867
• 负责人: DENNIS CARSON
• 金额: $ 40万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-30 至 2024-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10706867
• 关键词: Adaptive Immune System; Adjuvant; Antigens; Award; B-Lymphocytes; Cells; Contractor; Formulation; Human; Immunologic Memory; Innate Immune System; Ligands; Liposomes; Research; T-Lymphocyte; TLR4 gene; Vaccines; novel; pathogen; response; scale up; small molecule

The contractor will identify novel adjuvant candidates that can be used to augment the efficacy of human vaccines. Research performed under this award will contribute to the pipeline of new adjuvant leads that either: (a) exploit the natural capacity of the innate immune system to initiate and sustain effective T and B cell responses and to induce long term immune memory, or (b) act directly on cells of the adaptive immune system to enhance their response to pathogen-derived antigens.

承包商将确定可用于增强人类疫苗效力的新佐剂候选药物。在该奖项下进行的研究将有助于开发新的佐剂线索，这些线索要么：(A)利用天然免疫系统的天然能力，启动和维持有效的T和B细胞反应，并诱导长期免疫记忆；要么(B)直接作用于适应性免疫系统的细胞，以增强它们对病原体衍生抗原的反应。