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Discovery of agents that induce exosomes with adjuvant activity

Discovery of agents that induce exosomes with adjuvant activity
发现具有佐剂活性的外泌体诱导剂
批准号：
10834814
负责人：
DENNIS CARSON
金额：
$144.54万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
项目状态：
已结题
起止时间：
2019-09-30 至 2024-09-29
来源：
https://reporter.nih.gov/project-details/10834814
关键词：
Adaptive Immune SystemAdjuvantAnimal ModelAntigensAwardB-LymphocytesCattleCellsContractorFDA approvedFoot DiseasesGoatHumanImmune responseImmunologic MemoryInnate Immune SystemMouth DiseasesMusPreventive vaccineResearchSystemT-LymphocyteTestingVaccinesexosomehuman diseasenovelpathogenprotective efficacyresponsetherapeutic vaccinevaccine efficacy

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中文摘要
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英文摘要
The contractor will identify novel adjuvant candidates that can be used to augment the efficacy of human vaccines. Research performed under this award will contribute to the pipeline of new adjuvant leads that either: (a) exploit the natural capacity of the innate immune system to initiate and sustain effective T and B cell responses and to induce long term immune memory, or (b) act directly on cells of the adaptive immune system to enhance their response to pathogen-derived antigens. Studies include testing of adjuvant candidates with experimental or FDA approved preventative or therapeutic vaccines in relevant animal models to determine the potential efficacy of the vaccine against one or more pathogens relevant to human disease.
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Tetrahydrothieno[2,3-c]pyridines as Vaccine Co-adjuvants
Discovery of agents that induce exosomes with adjuvant activity
Discovery of agents that induce exosomes with adjuvant activity
Discovery of agents that induce exosomes with adjuvant activity
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