Adjuvant Discovery for Vaccines against West Nile Virus and Influenza

西尼罗河病毒和流感疫苗的佐剂发现

• 批准号: 9547196
• 负责人: DENNIS CARSON
• 金额: $ 157.73万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-30 至 2018-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9547196
• 关键词: Adjuvant; Animal Model; Cells; Contractor; Dendritic Cells; Emerging Communicable Diseases; Formulation; Human; Immunologic Receptors; Influenza; Interferons; Lead; Life; NF-kappa B; National Institute of Allergy and Infectious Disease; Pharmaceutical Chemistry; Research; Signal Pathway; Signal Transduction; Structure-Activity Relationship; Study models; Technology; Testing; Time; Vaccine Adjuvant; Vaccines; Validation; West Nile viral infection; West Nile virus; Work; base; high throughput screening; human disease; in vivo; novel; pathogen; programs; receptor; vaccine candidate; vaccine discovery

The Adjuvant Discovery Program supports the early stage discovery and initial characterization of novel adjuvant candidates for vaccines. The research must include (1) identification of novel adjuvant candidates through high throughput screening (HTS) approaches and validation that lead compounds stimulate human cells; (2) determination of the mechanism of action of select lead compounds, including the identification of the receptor(s) the adjuvant candidates work through and the cellular signaling pathways they activate; (3) optimization of lead adjuvant candidates through formulation and medicinal chemistry, guided by structure-activity relationship (SAR) studies; and (4) verification of the efficacy of lead compounds as vaccine adjuvants in vivo in an animal model. Projects must include animal model studies to test the adjuvant candidates with vaccines against: A) One or more NIAID Emerging and Re-emerging Infectious Disease Pathogens http://www.niaid.nih.gov/topics/emerging/pages/default.aspx), or B) One or more NIAID Emerging and Re-emerging Infectious Disease Pathogens as well as one or more other (non-HIV) pathogens relevant to human disease.

佐剂发现计划支持疫苗新型佐剂候选物的早期发现和初步表征。研究必须包括：（1）通过高通量筛选（HTS）方法鉴定新型佐剂候选物，并验证先导化合物刺激人类细胞;（2）确定选定先导化合物的作用机制，包括鉴定佐剂候选物通过的受体及其激活的细胞信号传导途径;（3）在结构-活性关系（SAR）研究的指导下，通过配方和药物化学优化先导佐剂候选物;和（4）在动物模型中验证先导化合物作为疫苗佐剂的体内功效。 项目必须包括动物模型研究，以测试候选佐剂与疫苗对： A）一种或多种NIAID新发和再发传染病病原体（http：//www.niaid.nih.gov/topics/emerging/pages/default.aspx），或 B）一种或多种NIAID新发和再发传染病病原体以及一种或多种与人类疾病相关的其它（非HIV）病原体。