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Small molecule stimulators of innate immune receptors

Small molecule stimulators of innate immune receptors
先天免疫受体的小分子刺激剂
批准号：
8751021
负责人：
DENNIS CARSON
金额：
$212.02万
依托单位：
CALIFORNIA UNIV SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
项目状态：
已结题
起止时间：
2009-09-30 至 2014-09-29
来源：
https://reporter.nih.gov/project-details/8751021
关键词：
AdjuvantAntigensB-LymphocytesBindingCellsCommunicable DiseasesContractsGoalsHumanImmune systemImmunologic AdjuvantsImmunologic ReceptorsIntramuscularLeadLibrariesPreclinical TestingRNA InterferenceReporterResearch PersonnelRouteSpecificityT-LymphocyteTLR1 geneTechniquesTechnologyVaccinesbasecell mediated immune responsehigh throughput screeningpreventprogramsreceptorsmall moleculesubcutaneous

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英文摘要
The goals of the Innate Immune Receptors and Adjuvant Discovery program are to discover, characterize, and support preclinical testing of new adjuvant candidates based upon triggering of the human innate immune system. Adjuvants are defined as molecules that act via innate immune receptors to activate beneficial innate and/or adaptive (T and B cell-mediated) immune responses. Using high throughput screening techniques, investigators will screen compound libraries to identify potential adjuvant products that may be developed as components of antigen specific vaccines against infectious disease, or may serve as stand-alone agents that transiently prevent or treat infectious disease.
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  • 批准号：
    2022J011295
  • 项目类别：
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  • 资助金额：
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