课题基金 / 基金详情

Cellular Responses to DNA Damage

Cellular Responses to DNA Damage
细胞对 DNA 损伤的反应
批准号：
10706918
负责人：
Peggy Hsieh
金额：
$47.37万
依托单位：
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/10706918
关键词：
ApoptosisApoptoticAtomic Force MicroscopyBiochemicalCell Cycle ArrestCell Cycle ProgressionCell DeathCellsChemical AgentsCollaborationsComplexDNADNA DamageDNA Repair PathwayGenome StabilityGoalsHumanIndividualLibrariesMammalian CellMethodsMismatch RepairMolecularMolecular ConformationMonitorNormal CellNuclear EnvelopePharmaceutical PreparationsProteinsReplication ErrorReporterResistanceSignal TransductionSmall Molecule Chemical LibrarySystemhigh throughput screeningpatient populationresponsescreening

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中文摘要
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英文摘要
The goal of this project is to understand at a molecular level the ways in which the DNA mismatch repair system corrects replication errors and how mammalian cells respond to DNA damage. In collaboration with Dr. Dorothy Erie, UNC-Chapel Hill, we have used atomic force microscopy and biochemical approaches to examine the conformations of individual protein-DNA complexes. We have developed a cell reporter system to screen for cell cycle arrest and apoptosis in high-throughput assays of small molecule chemical libraries. We hope this reporter system will yield important new information in early rounds of library screening for apoptotic agents.
期刊论文(4)
专著(0)
科研奖励(0)
会议论文
DNA mismatch repair: Dr. Jekyll and Mr. Hyde?
DOI： 10.1016/j.molcel.2012.08.020
发表时间： 2012-09-14
期刊： MOLECULAR CELL
影响因子： 16
作者： [Hsieh, Peggy]
通讯作者： Hsieh, Peggy
EGFR inhibits DNA mismatch repair.
EGFR 抑制 DNA 错配修复。
DOI： 10.1073/pnas.1505168112
发表时间： 2015
期刊： Proceedings of the National Academy of Sciences of the United States of America
影响因子： 11.1
作者： [Hsieh,Peggy, Pearlman,AlexanderH]
通讯作者： Pearlman,AlexanderH
DNA mismatch repair and the DNA damage response.
DOI： 10.1016/j.dnarep.2015.11.019
发表时间： 2016-02
期刊： DNA repair
影响因子： 3.8
作者： [Li Z, Pearlman AH, Hsieh P]
通讯作者： Hsieh P
Cellular Responses to DNA Damage
DNA Mismatch Repair
Molecular Studies Of Protein-DNA Interactions
Cellular Responses to DNA Damage
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