Stroke, Cognition and Neuroepidemiology Section
Stroke, Cognition and Neuroepidemiology Section
批准号:
10708648
负责人:
Rebecca F Gottesman
金额:
$138.98万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至
关键词:
Atherosclerosis Risk in CommunitiesBlood VesselsBrain hemorrhageCADASILCerebral small vessel diseaseCerebrovascular DisordersCognitionCognitiveCollaborationsComplementDementiaDiseaseEtiologyEvaluationExtramural ActivitiesFundingFutureGeneral PopulationGenesGoalsHealthHigh PrevalenceHumanImpaired cognitionIndividualInfarctionInheritedInterventionIntramural Research ProgramIschemic StrokeLife Cycle StagesMethodsMicrovascular DysfunctionNational Institute of Neurological Disorders and StrokeNeuroepidemiologyPathway interactionsPatternPopulation StudyPreventionRecoveryRecurrenceRiskRisk FactorsRoleStrokeUnited States National Institutes of HealthVascular Diseasesbaseblood-based biomarkerbrain healthcognitive changecognitive performancecohortdisparity reductionexperienceimaging biomarkermiddle agemodifiable riskneuroimagingpost strokesocial health determinantsvascular cognitive impairment and dementiavascular risk factor
中文摘要
血管危险因素与认知能力下降和痴呆有关,尤其是在中年评估时。这些相同的危险因素是否决定中风后认知障碍的风险尚不清楚,中风后血管风险普遍升高,其他可改变的危险因素的作用也不清楚。此外,血管影响认知的机制是否仅通过可识别的脑血管疾病成像标志物(如小血管疾病、无症状性梗死或微出血),或者是否存在血管风险导致认知障碍的其他机制,目前尚不清楚。扫描部分正在进行的研究评估了与VCID存在,病因和潜在预防途径相关的问题。
英文摘要
Vascular risk factors are associated with cognitive decline and dementia, especially when evaluated in middle age. Whether these same risk factors determine risk of cognitive impairment after stroke, a condition where vascular risk is generally elevated, is not clear, nor is the role of other modifiable risk factors. Furthermore, whether the mechanism of a vascular impact on cognition is solely via identifiable imaging markers of cerebrovascular disease (such as small vessel disease, silent infarcts or microbleeds) or whether there are other mechanisms by which vascular risk contributes to cognitive impairment is not well understood. Ongoing studies in the SCAN section evaluate related questions to VCID presence, etiology, and potential pathways for prevention.
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DISCOVERY - Statistics and Analysis Core
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批准号:10021041
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项目类别:
-
资助金额:$64.23万
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财政年份:2019
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负责人:Rebecca F Gottesman
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依托单位:
DISCOVERY - Statistics and Analysis Core
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批准号:10241403
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项目类别:
-
资助金额:$64.23万
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财政年份:2019
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负责人:Rebecca F Gottesman
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依托单位:
DISCOVERY - Statistics and Analysis Core
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批准号:10709865
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项目类别:
-
资助金额:$151.04万
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财政年份:2019
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负责人:Rebecca F Gottesman
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依托单位:
Neuroepidemiology of the vascular contribution to cognitive impairment and Alzheimer's disease
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批准号:9323230
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项目类别:
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资助金额:$16.05万
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财政年份:2016
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负责人:Rebecca F Gottesman
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依托单位:
Neuroepidemiology of the vascular contribution to cognitive impairment and Alzheimer's disease
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批准号:9922187
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项目类别:
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资助金额:$16.05万
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财政年份:2016
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负责人:Rebecca F Gottesman
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依托单位:
Neuroepidemiology of the vascular contribution to cognitive impairment and Alzheimer's disease
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批准号:9086843
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项目类别:
-
资助金额:$16.05万
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财政年份:2016
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负责人:Rebecca F Gottesman
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依托单位:
The ARIC-PET Amyloid Imaging Study
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批准号:8162024
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项目类别:
-
资助金额:$59.1万
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财政年份:2011
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负责人:Rebecca F Gottesman
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依托单位:
The ARIC-PET Amyloid Imaging Study
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批准号:9477412
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项目类别:
-
资助金额:$71.61万
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财政年份:2011
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负责人:Rebecca F Gottesman
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依托单位:
The ARIC-PET Amyloid Imaging Study
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批准号:8726266
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项目类别:
-
资助金额:$55.99万
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财政年份:2011
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负责人:Rebecca F Gottesman
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依托单位:
The ARIC-PET Amyloid Imaging Study
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批准号:8545376
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项目类别:
-
资助金额:$94.95万
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财政年份:2011
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负责人:Rebecca F Gottesman
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依托单位:
The ARIC-PET Amyloid Imaging Study
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批准号:8885622
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项目类别:
-
资助金额:$50.82万
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财政年份:2011
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负责人:Rebecca F Gottesman
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依托单位:
The ARIC-PET Amyloid Imaging Study
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批准号:9185481
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项目类别:
-
资助金额:$76.17万
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财政年份:2011
-
负责人:Rebecca F Gottesman
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依托单位:
The ARIC-PET Amyloid Imaging Study
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批准号:8495842
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项目类别:
-
资助金额:$53.41万
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财政年份:2011
-
负责人:Rebecca F Gottesman
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依托单位:
The ARIC-PET Amyloid Imaging Study
-
批准号:8328639
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项目类别:
-
资助金额:$56.96万
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财政年份:2011
-
负责人:Rebecca F Gottesman
-
依托单位:
The ARIC-PET Amyloid Imaging Study
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批准号:9925759
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项目类别:
-
资助金额:$68.38万
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财政年份:2011
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负责人:Rebecca F Gottesman
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依托单位:
The ARIC-PET Amyloid Imaging Study
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批准号:9346656
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项目类别:
-
资助金额:$72.37万
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财政年份:2011
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负责人:Rebecca F Gottesman
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依托单位:
DISCOVERY - Statistics and Analysis Core
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批准号:9918028
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项目类别:
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资助金额:$77.42万
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财政年份:--
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负责人:Rebecca F Gottesman
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依托单位:
Stroke, Cognition and Neuroepidemiology Section
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批准号:10916014
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项目类别:
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资助金额:$230.6万
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财政年份:--
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负责人:Rebecca F Gottesman
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依托单位:
海外基金