Next Generation Antibody Therapeutics

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This research will focus on an important problem, namely the limitations on specificity and persistence of human antibodies. Although often perceived as a perfect 'lock-and-key' phenomenon, many antibodies in fact display limited specificity and interact with unrelated targets resulting in short persistence and off-target effects. By deciphering mutational and structural mechanisms unpinning antibody specificity, my research will advance the development of next generation antibody therapeutics.