Positive and negative selection in the germinal centre reaction

生发中心反应中的阳性和阴性选择

• 批准号: nhmrc : GNT1105875
• 负责人: A/Pr Daniel Christ
• 金额: $ 129万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/positive-negative-selection-centre-reaction/1346471
• 关键词: Positive; negative; selection; germinal; centre

We will investigate the processes that control the production of antibodies by the immune system. In particular, we will determine how the immune system is normally prevented from producing autoantibodies that target the body's own cells and how this fails in the case of autoimmune diseases such as lupus. Targeted studies of a new type of 'rogue' white blood cell we have identified will also provide important clues on how autoantibody-producing cells escape and cause autoimmune disease.

我们将研究控制免疫系统产生抗体的过程。特别是，我们将确定免疫系统通常是如何防止产生针对人体自身细胞的自身抗体的，以及在狼疮等自身免疫性疾病的情况下，这是如何失败的。对我们发现的一种新型“流氓”白色血细胞的有针对性的研究也将为自身抗体产生细胞如何逃逸并导致自身免疫性疾病提供重要线索。