Evolutionary approaches to identify genetic architecture regulating aggression

识别调节攻击性的遗传结构的进化方法

• 批准号: 10797336
• 负责人: Johanna E. Kowalko
• 金额: $ 7.61万
• 依托单位: LEHIGH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-20 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10797336
• 关键词: Aggressive behavior; Behavior; Behavioral; Biological Models; Candidate Disease Gene; Chromosome Mapping; Complex; Evolution; Fishes; Genetic; Genetic Variation; Goals; Human; Individual; Individual Differences; Laboratories; Methods; Mexican; Molecular; Morphology; Natural Selections; Neurons; Organism; Persons; Physiological; Population; Research; Resources; Role; Social Behavior; Societies; Surface; System; Testing; base; blind; genetic architecture; genetic variant; genome resource; insight; model organism; neuromechanism; programs; tool; trait

Below is the original Summary to fill this mandatory field The overarching goal of my research program is to understand how naturally occurring genetic variation results in evolved differences in behaviors. To examine these relationships, it is imperative to have a model organism that is both genetically and behaviorally variable, as well as genetically accessible. Natural populations have evolved an extraordinary diversity of behaviors. Developing and applying functional genetic tools and genomic resources to organisms from these natural populations provides an opportunity to uncover the mechanisms by which natural selection has produced these behavioral differences. Further, these approaches may provide general insights into the molecular and genetic bases of social behaviors in other species, such as humans. The blind Mexican cavefish has evolved a variety of morphological, physiological and behavioral traits, including reductions in social behaviors like aggression, relative to surface fish of the same species. My laboratory has focused on establishing methods to identify and functionally validate the role of naturally occurring genetic variants in cavefish behavioral evolution. The research program outlined here will leverage this evolutionary system to identify the genetic architecture underlying within-population differences in aggression, and to test the mechanisms by which differences in aggression evolve. Utilizing genetic mapping approaches, we will identify and functionally test candidate genes for aggressive behavior. Further, using integrative approaches, we determine the mechanisms by which naturally occurring genetic variants impact behavior. Together, this research program will provide important insights into the genetic and neural mechanisms underlying variability in complex behaviors.

下面是填写此必填字段的原始摘要

项目成果

A brain-wide analysis maps structural evolution to distinct anatomical module.

• DOI: 10.7554/elife.80777
• 发表时间: 2023-07-27
• 期刊: eLife
• 影响因子: 7.7
• 作者: Kozol RA;Conith AJ;Yuiska A;Cree-Newman A;Tolentino B;Benesh K;Paz A;Lloyd E;Kowalko JE;Keene AC;Albertson C;Duboue ER
• 通讯作者: Duboue ER

Kinematic analysis of social interactions deconstructs the evolved loss of schooling behavior in cavefish.

• DOI: 10.1371/journal.pone.0265894
• 发表时间: 2022
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Patch A;Paz A;Holt KJ;Duboué ER;Keene AC;Kowalko JE;Fily Y
• 通讯作者: Fily Y

Changes in local interaction rules during ontogeny underlie the evolution of collective behavior.

个体发育过程中局部相互作用规则的变化是集体行为进化的基础。

• DOI: 10.1101/2023.03.28.534467
• 发表时间: 2023
• 期刊: bioRxiv : the preprint server for biology
• 作者: Paz,Alexandra;Holt,KarlaJ;Clarke,Anik;Aviles,Ari;Abraham,Briana;Keene,AlexC;Duboué,ErikR;Fily,Yaouen;Kowalko,JohannaE
• 通讯作者: Kowalko,JohannaE

Loci associated with cave-derived traits concentrate in specific regions of the Mexican cavefish genome.

与洞穴衍生性状相关的基因座集中在墨西哥洞穴鱼基因组的特定区域。

• DOI: 10.1101/2024.03.29.587360
• 发表时间: 2024
• 期刊: bioRxiv : the preprint server for biology
• 作者: Wiese,Jonathan;Richards,Emilie;Kowalko,JohannaE;McGaugh,SuzanneE
• 通讯作者: McGaugh,SuzanneE

Novel Husbandry Practices Result in Rapid Rates of Growth and Sexual Maturation Without Impacting Adult Behavior in the Blind Mexican Cavefish.

新的饲养方法可以使墨西哥盲眼洞穴鱼快速生长和性成熟，而不影响成年行为。

• DOI: 10.1089/zeb.2023.0001
• 发表时间: 2023
• 期刊: Zebrafish
• 影响因子: 2
• 作者: Kozol,RobertA;Yuiska,Anders;Han,JiHeon;Tolentino,Bernadeth;Lopatto,Arthur;Lewis,Peter;Paz,Alexandra;Keene,AlexC;Kowalko,JohannaE;Duboué,ErikR
• 通讯作者: Duboué,ErikR