COBRE in Digestive and Liver Diseases

COBRE 在消化系统和肝脏疾病中的应用

• 批准号: 10798819
• 负责人: STEPHEN A DUNCAN
• 金额: $ 24.93万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-04-03 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10798819
• 关键词: Animal Model; Award; Cell model; Cells; Centers of Research Excellence; Department chair; Development; Digestive System Disorders; Disease; Equipment; Evaluation; Funding; Gastrointestinal Diseases; Goals; Health; Human; Image; Institution; Interdisciplinary Study; Liver diseases; Medical; Medicine; Mentors; National Institute of Diabetes and Digestive and Kidney Diseases; Parents; Population; Research; Research Personnel; Resources; Source; South Carolina; Technology; Tissues; Treatment Cost; United States National Institutes of Health; Universities; burden of illness; college; cost estimate; design; improved; innovation; multidisciplinary; novel therapeutics; parent grant; programs; success

Abstract of Funded Parent Award The overall goal of the Center of Biomedical Research Excellence (COBRE) in Digestive & Liver Diseases (CDLD) is to enable outstanding multidisciplinary collaborative research in digestive and liver diseases at the Medical University of South Carolina. These diseases are of importance to the state of South Carolina because of the tremendous, disproportionate burden they have upon the state’s citizens. The specific aims are to: 1) Mentor an expanding cadre of successful Junior Investigators to become independently funded in digestive and liver disease research; 2) Develop innovative scientific core resources designed to stimulate and apply research discoveries in digestive and liver disease to improve human health; and 3) Sustain the CDLD and its long-term success through multidisciplinary research and programmatic evaluation and improvement strategies. The Center is led by a multidisciplinary team of two department chairs within the MUSC College of Medicine, coalescing resources to achieve their overarching objective of developing an NIDDK-funded Silvio O. Conte Digestive Disease Research Core Center at MUSC. Scientific cores include the: 1) Cell Models Core to generate advanced cell models of digestive and liver diseases; 2) Animal Models of Digestive Diseases Core to provide access to essential animal models; and 3) Advanced Imaging Core with sophisticated equipment, technologies and expertise required for successful, state-of-the-art cell and tissue-based imaging and analysis. This application highlights four Junior Investigators who will benefit from an innovative multiple source mentoring plan which features both internal and external mentors. With NIH and institutional support, the COBRE in Digestive & Liver Disease will facilitate the development of robust translational programs, ultimately leading to better mechanistic understanding with the potential for new therapeutic discoveries.

资助家长奖摘要 消化和肝病卓越生物医学研究中心（COBRE）的总体目标 （CDLD）是为了在消化和肝脏疾病方面进行杰出的多学科合作研究， 南卡罗来纳州医科大学。这些疾病对南卡罗来纳州很重要， 他们给国家公民带来的巨大的、不成比例的负担。具体目标是：1） 指导不断扩大的成功初级研究者骨干队伍，使其在消化和 肝病研究; 2）开发旨在刺激和应用研究的创新科学核心资源 消化和肝脏疾病的发现，以改善人类健康;和3）维持CDLD及其长期 通过多学科研究和方案评价以及改进战略取得成功。的 中心由MUSC医学院内的两个系主任组成的多学科团队领导， 整合资源，以实现其总体目标，即开发一个由NIDDK资助的Silvio O。孔戴 MUSC消化疾病研究核心中心。科学核心包括：1）细胞模型核心， 消化道和肝脏疾病的先进细胞模型; 2）消化道疾病的动物模型核心提供 获得基本的动物模型;和3）先进的成像核心与先进的设备， 以及成功进行最先进的细胞和组织成像和分析所需的专业知识。这 申请突出了四名初级研究员，他们将受益于创新的多源指导计划 包括内部和外部导师。在NIH和机构的支持下，消化系统中的COBRE 和肝病将促进强大的翻译计划的发展，最终导致更好的 机械的理解与新的治疗发现的潜力。

项目成果

Hemoglobin Monitoring in Acute Gastrointestinal Bleeding: Are We Monitoring Blood Counts Too Frequently?

• DOI: 10.1016/j.amjmed.2020.09.056
• 发表时间: 2021-05
• 期刊: The American journal of medicine
• 作者: Jaben I;Sasso R;Rockey DC
• 通讯作者: Rockey DC

The cellular microenvironment and cytoskeletal actin dynamics in liver fibrogenesis.

• DOI: 10.32604/biocell.2022.020171
• 发表时间: 2022-05-18
• 期刊: Biocell : official journal of the Sociedades Latinoamericanas de Microscopia Electronica ... et. al
• 作者: Hijazi N;Rockey DC;Shi Z
• 通讯作者: Shi Z

Chronic complement dysregulation drives neuroinflammation after traumatic brain injury: a transcriptomic study.

• DOI: 10.1186/s40478-021-01226-2
• 发表时间: 2021-07-19
• 期刊: Acta neuropathologica communications
• 影响因子: 7.1
• 作者: Toutonji A;Mandava M;Guglietta S;Tomlinson S
• 通讯作者: Tomlinson S

Complement downregulation promotes an inflammatory signature that renders colorectal cancer susceptible to immunotherapy.

• DOI: 10.1136/jitc-2022-004717
• 发表时间: 2022-09
• 期刊: Journal for immunotherapy of cancer
• 影响因子: 10.9

Acute Liver Injury in Patients Hospitalized with COVID-19.

• DOI: 10.1007/s10620-021-07230-9
• 发表时间: 2022-08
• 期刊: Digestive diseases and sciences
• 影响因子: 3.1
• 作者: Sobotka LA;Esteban J;Volk ML;Elmunzer BJ;Rockey DC;North American Alliance for the Study of Digestive Manifestation of COVID-19*
• 通讯作者: North American Alliance for the Study of Digestive Manifestation of COVID-19*