Dysfunctional behavior with friends during middle childhood as a precursor to borderline personality pathology

童年中期与朋友的功能失调行为是边缘人格病理学的先兆

基本信息

批准号：
10806402
负责人：
Salome Vanwoerden
金额：
$ 17.62万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-09-05 至 2028-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10806402
关键词：
Accounting Address Adolescence Affective Age Arousal Behavior Behavioral Borderline Personality Disorder Child Child Rearing Childhood Clinical Conflict (Psychology)Control Groups Cues Data Analyses Depressed mood Development Disease Early Intervention Early identification Emotional Etiology Exhibits Family Female Fostering Friends Friendships Functional disorder Gender Genetic Goals Hypersensitivity Institution Life Maternal Age Measurement Measures Mental Depression Mental disorders Mentors Methods Modeling Mother-Child Relations Mothers National Institute of Mental Health Parent-Child Relations Parents Pathology Patient Self-Report Pattern Personality Personality Traits Phase Phenotype Physiological Prevention Process Psychiatry Psychologist Psychopathology Psychophysiology Public Health Questionnaires Race Reporting Research Research Design Research Personnel Research Support Risk Specificity Strategic Planning Systems Theory Testing Time Training Universities Work Youth behavior observation comorbidity cost design dynamic system emotion dysregulation experience follow-up high risk human old age (65+)in vivo insight intergenerational intimate behavior middle childhood multimodality offspring peer preventive intervention programs response satisfaction severe mental illness social societal costs sociodemographic factors symptomatology teacher transmission process

项目摘要

PROJECT SUMMARY/ABSTRACT Borderline personality disorder (BPD) is a serious mental disorder associated with high cost that is transmitted intergenerationally. The interpersonal phenotype of BPD is characterized by hypersensitivity, hostile attribution bias, and maladaptive desire for exclusivity in relationships. Features of this phenotype can be identified in childhood and are associated with internalizing and externalizing pathology as well as later development of BPD. Aligned with the 2021 NIMH Strategic Plan, to identify malleable targets for prevention of psychopathology, it is necessary to study the unfolding of this critical mechanism prior to the onset of symptomatology. This proposal aims to do so among high-risk youth (based on maternal psychopathology) during middle childhood (ages 7-9; 50% female), a critical time for interpersonal development. This study measures the interpersonal features of BPD in the context of child-friend interactions to leverage multi-modal assessment and to focus on a central relationship of this developmental phase. Specific aims of the study are to 1) Test whether offspring of mothers with BPD (n=60) exhibit interpersonal features of BPD during middle childhood compared to offspring of mothers with depression (n=60) and non-disordered mothers (n=40); 2) Determine the extent to which BPD interpersonal features in middle childhood impede the development of friendship; and 3) Test associations between BPD interpersonal features and development of psychopathology in children. Friendship stability and quality and child psychopathology (internalizing, externalizing, BPD features) will be assessed at baseline and 6-months. The central hypothesis is that relative to controls, offspring of mothers with BPD are at highest risk of exhibiting interpersonal dysfunction that is specific to BPD during middle childhood. These behaviors have a negative effect on a central developmental milestone of middle childhood: fostering of closeness in friendship, which increases risk a range of psychopathology including BPD. The candidate, Dr. Vanwoerden, is a clinical psychologist seeking to transition to an independent research program focused on the early identification and prevention of BPD. This project is a first step toward this goal with a comprehensive training plan addressing the research questions while building on previous experiences in important ways. First, she will obtain training on the inclusion and assessment of children and friends in research. Second, she will focus on (dyadic) measurement and interpretation of electrodermal activity as a physiological marker of hypersensitivity. Third, she will gain proficiency in longitudinal research design, including retention of high-risk families and the analysis of data using methods aligned with dynamic systems theory. Drs. Stephanie Stepp, Amanda Rose, and Lauren Bylsma who have expertise in the developmental psychopathology of BPD, friendship processes, and psychophysiological assessment, respectively, will jointly mentor Dr. Vanwoerden. The research and training plan will be conducted at the University of Pittsburgh, Department of Psychiatry, a leading research institution with extensive research support, world class developmental psychopathology researchers, and state-of-the-art facilities.

项目摘要/摘要边缘性人格障碍（BPD）是一种与高成本相关的严重精神障碍综合性。 BPD的人际表型的特征是超敏反应，敌对归因偏见和对人际关系中排他性的不良渴望。该表型的特征可以在童年时期，与内部化和外在的病理以及后来的BPD发展有关。与2021年NIMH战略计划保持一致，以确定预防心理病理学的可延展目标，这是在症状发作之前研究这种关键机制的发展所必需的。这个建议旨在在儿童中期的高风险青年（基于孕产妇的心理病理学）中这样做（7-9岁；女性为50％），是人际发展的关键时机。这项研究衡量了人际特征 BPD在儿童朋友互动的背景下以利用多模式评估并专注于中心这个发展阶段的关系。该研究的具体目的是1）测试母亲的后代是否与母亲的后代相比抑郁症（n = 60）和非疾病的母亲（n = 40）； 2）确定BPD人际关系的程度童年时期的特征阻碍了友谊的发展； 3）BPD之间的测试关联儿童心理病理学的人际特征和发展。友谊稳定，质量和孩子心理病理学（内部化，外部化，BPD特征）将在基线和6个月时进行评估。这中心假设是，相对于对照组，BPD母亲的后代有最高的风险在儿童中期特定于BPD的人际功能障碍。这些行为具有负面影响在中央童年的中心发展里程碑上：养育友谊的亲密关系，这增加了冒着包括BPD在内的一系列心理病理学的风险。候选人Vanwoerden博士是临床心理学家试图过渡到一个独立研究计划，重点是早期识别和预防 BPD。该项目是实现这一目标的第一步，该计划是针对研究的全面培训计划在以重要方式建立以前的经验的同时。首先，她将获得有关包容的培训以及研究中儿童和朋友的评估。其次，她将专注于（二元）测量和将电性活性解释为超敏反应的生理标志。第三，她会收获能够熟练纵向研究设计，包括保留高风险家族和使用数据分析与动态系统理论一致的方法。博士。 Stephanie Stepp，Amanda Rose和Lauren Bylsma 在BPD的发展心理病理学，友谊过程和心理生理学方面具有专业知识评估分别将共同指导Vanwoerden博士。研究和培训计划将进行在匹兹堡大学精神病学系，一家领先的研究机构，拥有广泛的研究支持，世界一流的发展心理病理学研究人员和最先进的设施。