Dysfunctional behavior with friends during middle childhood as a precursor to borderline personality pathology

童年中期与朋友的功能失调行为是边缘人格病理学的先兆

• 批准号: 10806402
• 负责人: Salome Vanwoerden
• 金额: $ 17.62万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-05 至 2028-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10806402
• 关键词: Accounting; Address; Adolescence; Affective; Age; Arousal; Behavior; Behavioral; Borderline Personality Disorder; Child; Child Rearing; Childhood; Clinical; Conflict (Psychology); Control Groups; Cues; Data Analyses; Depressed mood; Development; Disease; Early Intervention; Early identification; Emotional; Etiology; Exhibits; Family; Female; Fostering; Friends; Friendships; Functional disorder; Gender; Genetic; Goals; Hypersensitivity; Institution; Life; Maternal Age; Measurement; Measures; Mental Depression; Mental disorders; Mentors; Methods; Modeling; Mother-Child Relations; Mothers; National Institute of Mental Health; Parent-Child Relations; Parents; Pathology; Patient Self-Report; Pattern; Personality; Personality Traits; Phase; Phenotype; Physiological; Prevention; Process; Psychiatry; Psychologist; Psychopathology; Psychophysiology; Public Health; Questionnaires; Race; Reporting; Research; Research Design; Research Personnel; Research Support; Risk; Specificity; Strategic Planning; Systems Theory; Testing; Time; Training; Universities; Work; Youth; behavior observation; comorbidity; cost; design; dynamic system; emotion dysregulation; experience; follow-up; high risk; human old age (65+); in vivo; insight; intergenerational; intimate behavior; middle childhood; multimodality; offspring; peer; preventive intervention; programs; response; satisfaction; severe mental illness; social; societal costs; sociodemographic factors; symptomatology; teacher; transmission process

PROJECT SUMMARY/ABSTRACT Borderline personality disorder (BPD) is a serious mental disorder associated with high cost that is transmitted intergenerationally. The interpersonal phenotype of BPD is characterized by hypersensitivity, hostile attribution bias, and maladaptive desire for exclusivity in relationships. Features of this phenotype can be identified in childhood and are associated with internalizing and externalizing pathology as well as later development of BPD. Aligned with the 2021 NIMH Strategic Plan, to identify malleable targets for prevention of psychopathology, it is necessary to study the unfolding of this critical mechanism prior to the onset of symptomatology. This proposal aims to do so among high-risk youth (based on maternal psychopathology) during middle childhood (ages 7-9; 50% female), a critical time for interpersonal development. This study measures the interpersonal features of BPD in the context of child-friend interactions to leverage multi-modal assessment and to focus on a central relationship of this developmental phase. Specific aims of the study are to 1) Test whether offspring of mothers with BPD (n=60) exhibit interpersonal features of BPD during middle childhood compared to offspring of mothers with depression (n=60) and non-disordered mothers (n=40); 2) Determine the extent to which BPD interpersonal features in middle childhood impede the development of friendship; and 3) Test associations between BPD interpersonal features and development of psychopathology in children. Friendship stability and quality and child psychopathology (internalizing, externalizing, BPD features) will be assessed at baseline and 6-months. The central hypothesis is that relative to controls, offspring of mothers with BPD are at highest risk of exhibiting interpersonal dysfunction that is specific to BPD during middle childhood. These behaviors have a negative effect on a central developmental milestone of middle childhood: fostering of closeness in friendship, which increases risk a range of psychopathology including BPD. The candidate, Dr. Vanwoerden, is a clinical psychologist seeking to transition to an independent research program focused on the early identification and prevention of BPD. This project is a first step toward this goal with a comprehensive training plan addressing the research questions while building on previous experiences in important ways. First, she will obtain training on the inclusion and assessment of children and friends in research. Second, she will focus on (dyadic) measurement and interpretation of electrodermal activity as a physiological marker of hypersensitivity. Third, she will gain proficiency in longitudinal research design, including retention of high-risk families and the analysis of data using methods aligned with dynamic systems theory. Drs. Stephanie Stepp, Amanda Rose, and Lauren Bylsma who have expertise in the developmental psychopathology of BPD, friendship processes, and psychophysiological assessment, respectively, will jointly mentor Dr. Vanwoerden. The research and training plan will be conducted at the University of Pittsburgh, Department of Psychiatry, a leading research institution with extensive research support, world class developmental psychopathology researchers, and state-of-the-art facilities.

项目总结/文摘