Duke CTSA

杜克大学CTSA

• 批准号: 10817426
• 负责人: JENNIFER S LI
• 金额: $ 733.62万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-05-02 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10817426
• 关键词: Achievement; Arts; Businesses; Clinical; Clinical Sciences; Clinical and Translational Science Awards; Collaborations; Communities; Discipline of Nursing; Diverse Workforce; Engineering; Ensure; Faculty; Fostering; Funding; Health; Health Benefit; Healthcare Systems; Industry; Infrastructure; Institution; Methods; Mission; Multi-Institutional Clinical Trial; National Center for Advancing Translational Sciences; Outcome Measure; Patients; Phase; Policy Maker; Population; Process; Public Health; Research; Research Personnel; Resources; Science; Scientist; Team Process; Training; Translational Research; Translations; Trust; United States; United States National Institutes of Health; Universities; experience; improved; innovation; medical schools; population health; programs; skills

The mission of the Duke Clinical and Translational Science Institute is to catalyze the translation of scientific discoveries into population health benefits through collaborative research. With previous Clinical and Translational Science Award (CTSA) funding, we have successfully developed infrastructure and provided resources to support investigators across the clinical and translational scientific and workforce spectrums. Our achievements have facilitated high-impact discoveries, increased research efficiency, and nurtured a more capable and diverse workforce. We have also ignited a new era of collaborative science at Duke. Several new transdisciplinary programs have been launched, connecting trainees and faculty from our Schools of Medicine, Nursing, Engineering, Business, and Arts and Sciences to enhance translation. In the next phase, Duke proposes to capitalize on new opportunities with three broad initiatives. First, we will optimize clinical and translational science national networks’ methods and processes. Building on Duke’s leading experience coordinating multi-center clinical trials including its national Duke-Vanderbilt NCATS Trial Innovation Center, we will develop methods to optimize ‘local hub,’ ‘hub-to-network’ and ‘network-to-network’ processes for the NCATS Trial Innovation Network. We will also help investigators leverage a number of additional NIH network resources and provide methods to disseminate best practices throughout the CTSA network. Second, we will deepen, nurture, and extend stakeholder collaborations. We will strengthen existing partnerships and foster new ones with stakeholders at both the institutional and investigator levels. Partnerships and programs will expand the breadth and transparency of CTSI activities. We will also support investigators’ greater engagement with a broad range of patients, community groups, clinicians, health care systems, industry, venture capitalists, payers, policy makers, and others. Third, we will catalyze further science integration at Duke. An invigorated professional workforce will facilitate major transdisciplinary science initiatives. A new University-wide coordination infrastructure will further amplify collaboration and bridge science siloes. We will also support teams by improving their skills in team science, studying team processes, and by promoting the recognition of team contributions at our institution. Collectively, these activities will amplify the innovation and impact of our research nationally, regionally, and locally. We will measure outcomes that reflect improvement in the translation of discoveries, use of national best practices, institutional and investigator teamwork, research transparency, and community trust. We will share all best practices with the CTSA network. We believe our achievements will meaningfully enhance the impact of clinical and translational science on health across the United States.

杜克临床和转化科学研究所的使命是促进科学翻译， 通过合作研究将发现转化为人口健康益处。与以前的临床和 转化科学奖（CTSA）的资金，我们已经成功地开发了基础设施，并提供了 资源，以支持临床和转化科学和劳动力范围内的研究者。我们 这些成就促进了高影响力的发现，提高了研究效率，并培养了更多的 有能力和多样化的劳动力。我们还在杜克大学开启了一个合作科学的新时代。几个新 跨学科项目已经启动，将我们医学院的学员和教师联系起来， 护理，工程，商业，艺术和科学，以加强翻译。在下一阶段，杜克 建议通过三项广泛的举措来利用新的机遇。首先，我们将优化临床和 翻译科学国家网络的方法和过程。基于杜克的领先经验 协调多中心临床试验，包括其国家杜克-范德比尔特NCATS试验创新中心， 我们将开发优化“本地枢纽”、“枢纽到网络”和“网络到网络”流程的方法， NCATS试验创新网络。我们还将帮助研究人员利用一些额外的NIH网络， 资源，并提供方法，以传播整个CTSA网络的最佳做法。二是 深化、培育和扩大利益相关者的合作。我们将加强现有的伙伴关系， 与机构和调查员两级的利益攸关方建立新的伙伴关系。伙伴关系和方案将 扩大CTSI活动的广度和透明度。我们还将支持调查人员进行更大的 与广泛的患者，社区团体，临床医生，医疗保健系统，行业， 风险投资家、付款人、政策制定者和其他人。第三，我们将促进进一步的科学整合， 杜克。一支训练有素的专业队伍将促进重大的跨学科科学举措。一个新 大学范围内的协调基础设施将进一步扩大合作，弥合科学孤岛。我们将 我还通过提高团队科学技能、研究团队流程以及促进 对我们机构团队贡献的认可。总的来说，这些活动将扩大创新， 我们的研究对国家、地区和地方的影响。我们将衡量反映改进的结果 在发现的转化、国家最佳做法的使用、机构和研究者的团队合作方面， 研究透明度和社区信任。我们将与CTSA网络分享所有最佳实践。我们 我相信我们的成就将有意义地增强临床和转化科学对健康的影响 在美国各地。

项目成果

Racial Disparities in Lung Cancer Screening Among Veterans, 2013 to 2021.

• DOI: 10.1001/jamanetworkopen.2023.18795
• 发表时间: 2023-06-01
• 期刊: JAMA NETWORK OPEN
• 影响因子: 13.8
• 作者: Navuluri, Neelima;Morrison, Samantha;Green, Cynthia L.;Woolson, Sandra L.;Riley, Isaretta L.;Cox, Christopher E.;Zullig, Leah L.;Shofer, Scott
• 通讯作者: Shofer, Scott

Image Quality and Dose Comparison of 3 Mobile Intraoperative Three-Dimensional Imaging Systems in Spine Surgery.

• DOI: 10.1016/j.wneu.2021.12.103
• 发表时间: 2022-04
• 期刊: WORLD NEUROSURGERY
• 影响因子: 2
• 作者: Foster, Norah;Shaffrey, Christopher;Buchholz, Avery;Turner, Raymond;Yang, Lexie Zidanyue;Niedzwiecki, Donna;Goode, Allen
• 通讯作者: Goode, Allen

Predicting postoperative complications in pediatric surgery: A novel pediatric comorbidity index.

• DOI: 10.1016/j.jpurol.2022.03.007
• 发表时间: 2022-06
• 期刊: JOURNAL OF PEDIATRIC UROLOGY
• 影响因子: 2
• 作者: Tejwani, Rohit;Lee, Hui-Jie;Hughes, Taylor L.;Hobbs, Kevin T.;Aksenov, Leonid, I;Scales, Charles D.;Routh, Jonathan C.
• 通讯作者: Routh, Jonathan C.

Going beyond the means: Exploring the role of bias from digital determinants of health in technologies.

• DOI: 10.1371/journal.pdig.0000244
• 发表时间: 2023-10
• 期刊: PLOS digital health

Characterization of Isavuconazole serum concentrations after enteral feeding tube administration in a hospitalized cohort: A case series.

• DOI: 10.1111/jcpt.13317
• 发表时间: 2021-04
• 期刊: Journal of clinical pharmacy and therapeutics
• 影响因子: 2
• 作者: Spivey J;Wrenn R;Liu B;Maziarz E;Kram B
• 通讯作者: Kram B