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Impact of Time-Restricted Feeding in Reducing Cancer Risk Through Optimizing Mitochondria Function

限时喂养通过优化线粒体功能来降低癌症风险

基本信息

批准号：
10829772
负责人：
Satchidananda Panda
金额：
$ 18.84万
依托单位：
SALK INSTITUTE FOR BIOLOGICAL STUDIES
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-01 至 2026-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10829772
关键词：
Administrative Supplement Adopted Adoption Adoptive Transfer Adult Affect Animals Automobile Driving Behavior Brain region Calories Cardiometabolic Disease Cells Chronic Disease Circadian Dysregulation Circadian Rhythms Clinical Trials Consumption Data Diet Dietary Intervention Dietary Practices Dietary Supplementation Eating Energy Intake Funding Gene Expression Health Benefit Hormonal Hormones Hour Human Intake Intermittent fasting Intervention Life Style Link Malignant Neoplasms Mediating Melatonin Metabolism Mitochondria Muscle Mitochondria Normal Cell Organ Oxidative Stress Participant Patient Self-Report Pattern Physiology Plasma Production Randomized, Controlled Trials Regulation Research Risk Risk Factors Rodent Role Sampling Sleep Sleep Wake Cycle Sleep disturbances Testing Time Time-restricted feeding arm attenuation body system cancer cell cancer prevention cancer risk cardiometabolic risk cultural health dietary supplements experimental study falls fire fighter improved lifestyle intervention melatonin supplementation nutrition pharmacologic pleiotropism post intervention response shift work sleep onset standard of care tumor growth

项目摘要

Project Summary. This request for an administrative supplement is submitted in response to PA-20-227 - Administrative Supplements for Research on Dietary Supplements (Admin Supp Clinical Trial Not Allowed]. The use of melatonin as a dietary supplement to support sleep and reduce cancer risk is rapidly growing. Melatonin is extensively studied as a hormonal marker of the circadian rhythm, however, its function in relation of diet or dietary patterns is rarely studied. The synthesis, metabolism, and mode of action of melatonin are tightly linked to mitochondria function. Hence, lifestyles influencing mitochondria function are highly likely to modulate melatonin production, degradation, and activity. Time-restricted feeding/eating (TRF/TRE) is a dietary intervention that limits daily calorie intake to a consistent window of 6-12 hours. TRF in animals systemically affect mitochondria function in multiple organs and brain regions. Human participants undergoing TRE intervention also show improvement in muscle mitochondria function. These preliminary observations raise the hypothesis that eating patterns can modulate melatonin function. This supplemental funding request will leverage the recently concluded randomized controlled trial on 10 h TRE among shift workers. Plasma collected at baseline and post-intervention will be used to test whether TRE affects the plasma levels of melatonin and its metabolites. Next, plasma adoptive transfer experiments will quantitatively assess the impact of plasma from TRE alone or in combination with supplemental melatonin on mitochondria function in normal and cancer cells. Successful completion of these aims will, for the first time, demonstrate whether TRE affects plasma melatonin levels and how TRE and melatonin interact to influence mitochondria function in normal cells and in cancer.

项目总结。