Pittsburgh Liver Research Center

摘要(摘自父母赠款P30DK120531，题为匹兹堡肝脏研究中心；PI：蒙加，萨达山)： 匹兹堡肝脏研究中心(PLRC)于2016年成立，是领导层高度热情的结果， 它得到了强有力的机构支持和承诺，以资源的形式从两个大学 匹兹堡医学中心(UPMC)和匹兹堡大学(UP)。PLRC真正代表了一种成功的合作伙伴关系 UPMC是医疗保健提供的先驱，UP是研究、发现、教育和 创新。其中心使命是促进对细胞和分子基础的理解 在肝胆损伤和修复方面，PLRC汇集了一批非常强大的研究人员和临床医生 从事基础和转化性肝脏研究，并为肝脏患者提供临床护理。在过去的两年里， PLRC的成员包括80名研究人员和临床医生(49名正式成员)，他们代表 UP和UPMC内的多个部门和机构，作为一个社区。这是由Regular推动的 网络、医生-基础科学家圆桌会议、研讨会和研讨会，以丰富环境，使之 有利于加强现有合作和启动新的伙伴关系。PLRC已将自己组织成3个 高功能科学利益集团(SIG)−再生医学、慢性肝病和肝脏 肿瘤发生−具有重叠的成员和定期安排的相互作用，促进了科学上具有生育能力的 通过一个相当新颖的浓缩计划为对话创造环境。Sig型圆桌会议允许重复对话 医生和科学家之间就精心挑选的主题进行合作，促进合作和更有意义的研究。 为了在PLRC研究人员的实验室中支持先锋和有影响力的科学，我们建立了3个高度集成的 生物医学研究核心和临床组件，提供最先进的创新服务，使 从长凳到床边的尖端研究和翻译。同样，PLRC确定了新的调查人员，并通过 试点和可行性计划，通过以下方式支持他们作为独立调查人员的研发 除了科学支持外，还提供纵向指导，并提供职业和职业发展活动。 通过机构支持的特别奖项允许为促进医生和基础科学家的团队科学项目提供资金 互动、技术开发和商业化。以上所有服务和功能都是针对 通过肝胆损伤和修复领域的研究识别肝脏健康和疾病中的复杂磨难 通过促进创新、协作的跨学科、跨学科和多学科研究，产生可持续的影响 在人类健康方面，由行政部门提供的强有力的领导和组织来确保 核心。事实上，PLRC领导层已经利用了该研究所的许多现有优势，如CTSI、创新研究所 以及库尔特计划以及与匹兹堡癌症大学等现有研究机构的联盟 Starzl移植研究所和McGowan再生医学研究所扩大服务和 PLRC为其所有成员提供的利益，并最终改善他们的科学、翻译和商业化。 因此，最终，通过他们的综合服务和方案，PLRC的长期目标是促进 在肝胆病理生理学领域的有影响力的科学，并改善肝脏的健康和护理，包括本地和 全球范围内。

Abstract (from parent grant P30DK120531 entitled Pittsburgh Liver Research Center; PI: Monga, Satdarshan): The inception of the Pittsburgh Liver Research Center (PLRC) in 2016 was the result of high enthusiasm of the leadership, which came with strong institutional support and commitment in the form of resources from both the University of Pittsburgh Medical Center (UPMC) and the University of Pittsburgh (UP). PLRC truly represents a successful partnership between UPMC, a pioneer in healthcare delivery and the UP, a renowned leader in research, discovery, education, and innovation. With the centralized mission of promoting the understanding of the cellular and molecular basis of hepatobiliary injury and repair, the PLRC has brought together a very strong group of investigators and clinicians engaged in basic and translational liver research and in the delivery of clinical care to liver patients. Over the last 2 years, PLRC has brought together the membership composed of 80 investigators and clinicians (49 full members) representing multiple departments and institutions within the UP and UPMC, as one community. This was facilitated by regular networking, physician-basic scientist roundtables, seminars and workshops, to enrich the environment making it conducive to strengthening existing collaborations and initiating new partnerships. PLRC has organized itself into 3 highly functional scientific interest groups (SIGs)−Regenerative Medicine, Chronic Liver Diseases, and Liver Tumorigenesis−with overlapping membership and regularly scheduled interactions facilitating a scientifically fertile environment for dialogue through a rather novel Enrichment program. SIG roundtables allow recurring dialogue between physicians and scientists on carefully selected topics and foster collaborations and more meaningful research. To enable pioneering and impactful science in the labs of PLRC investigators, we have established 3 highly integrated biomedical research cores and a clinical component that provide state-of-the-art and innovative services to enable cutting-edge research and translation from bench to bedside. Likewise, PLRC identifies new investigators and, through Pilot and Feasibility programs, supports their research and development as independent investigators through longitudinal mentorship and offering career and professional development activities in addition to scientific support. Special awards via institutional support allow funding of team science projects that promote physician and basic scientist interactions, technology development and commercialization. All of the above services and functions that are aimed at discerning complex tribulations in hepatic health and disease via research in the area of hepatobiliary injury and repair through promoting innovative, collaborative inter-, trans and multi-disciplinary research, to make a sustainable impact on human health, are ensured by a strong leadership and organization provided under the aegis of an Administrative Core. In fact, the PLRC leadership has leveraged many existing strengths of the institute like CTSI, Innovation Institute and the Coulter program as well as formed alliances with existing institutes like the University of Pittsburgh Cancer Institute, Starzl Transplant Institute and the McGowan Institute of Regenerative Medicine to expand services and benefits provided by the PLRC to all its members and eventually better their science, translation and commercialization. Thus, eventually, through their integrated services and programs, the long-term objective of the PLRC is to promote impactful science in the area of hepatobiliary pathophysiology and improve the hepatic health and care, both locally and globally.