Pittsburgh Liver Research Center

匹兹堡肝脏研究中心

基本信息

批准号：
10379013
负责人：
Satdarshan Singh Monga
金额：
$ 4.63万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-07-01 至 2022-03-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10379013
关键词：
Academic Medical Centers Administrative Supplement Area Award Basic Science Biology Biomedical Research Cells Clinical Collaborations Communities Complex Comprehension Core Facility Development Digestive System Disorders Disease Education Educational workshop Electronic Mail Ensure Environment Equipment Fostering Functional disorder Funding Goals Health Healthcare Hepatic Hepatic Tissue Hepatobiliary Hepatocarcinogenesis Hepatocyte Human Individual Infrastructure Institutes Institution Instruction Interdisciplinary Study Interest Group Investigation Leadership Liver Liver diseases Medical center Medicine Mentors Mentorship Mission Molecular Pathology Patients Physicians Process Records Regenerative Medicine Research Research Personnel Resources Schedule Science Scientist Services Technology Time Tissue Sample Tissue imaging Translations Transplantation Universities University of Pittsburgh Cancer Institute Wait Time Work base bench to bedside career cellular imaging chronic liver disease clinical care clinical practice commercialization cost cryostat environmental enrichment for laboratory animals health care delivery human disease imaging facilities improved improved outcome injury and repair innovation interdisciplinary collaboration interest member multidisciplinary next generation novel programs prospective recruit research and development response service delivery service programs success technology development

项目摘要

The inception of the Pittsburgh Liver Research Center (PLRC) in 2016 was the result of high enthusiasm of the leadership, which came with strong institutional support and commitment in the form of resources from both the University of Pittsburgh Medical Center (UPMC) and the University of Pittsburgh (UP). PLRC truly represents a successful partnership between UPMC, a pioneer in healthcare delivery and the UP, a renowned leader in research, discovery, education, and innovation. With the centralized mission of promoting the understanding of the cellular and molecular basis of hepatobiliary injury and repair, the PLRC has brought together a very strong group of investigators and clinicians engaged in basic and translational liver research and in the delivery of clinical care to liver patients. Over the last 2 years, PLRC has brought together the membership composed of 80 investigators and clinicians (49 full members) representing multiple departments and institutions within the UP and UPMC, as one community. This was facilitated by regular networking, physician- basic scientist roundtables, seminars and workshops, to enrich the environment making it conducive to strengthening existing collaborations and initiating new partnerships. PLRC has organized itself into 3 highly functional scientific interest groups (SIGs)−Regenerative Medicine, Chronic Liver Diseases, and Liver Tumorigenesis−with overlapping membership and regularly scheduled interactions facilitating a scientifically fertile environment for dialogue through a rather novel Enrichment program. SIG roundtables allow recurring dialogue between physicians and scientists on carefully selected topics and foster collaborations and more meaningful research. To enable pioneering and impactful science in the labs of PLRC investigators, we have established 3 highly integrated biomedical research cores and a clinical component that provide state-of-the-art and innovative services to enable cutting-edge research and translation from bench to bedside. Likewise, PLRC identifies new investigators and, through Pilot and Feasibility programs, supports their research and development as independent investigators through longitudinal mentorship and offering career and professional development activities in addition to scientific support. Special awards via institutional support allow funding of team science projects that promote physician and basic scientist interactions, technology development and commercialization. All of the above services and functions that are aimed at discerning complex tribulations in hepatic health and disease via research in the area of hepatobiliary injury and repair through promoting innovative, collaborative inter-, trans and multi-disciplinary research, to make a sustainable impact on human health, are ensured by a strong leadership and organization provided under the aegis of an Administrative Core. In fact, the PLRC leadership has leveraged many existing strengths of the institute like CTSI, Innovation Institute and the Coulter program as well as formed alliances with existing institutes like the University of Pittsburgh Cancer Institute, Starzl Transplant Institute and the McGowan Institute of Regenerative Medicine to expand services and benefits provided by the PLRC to all its members and eventually better their science, translation and commercialization. Thus, eventually, through their integrated services and programs, the long-term objective of the PLRC is to promote impactful science in the area of hepatobiliary pathophysiology and improve the hepatic health and care, both locally and globally.

2016年匹兹堡肝脏研究中心（PLRC）的诞生是高热情的结果领导力，这两者都以资源的形式带来了强烈的机构支持和承诺匹兹堡大学医学中心（UPMC）和匹兹堡大学（UP）。真正的PLRC 代表UPMC，医疗保健提供的先驱与UP的成功伙伴关系，是一个著名的研究，发现，教育和创新领域的领导者。以促进的集中任务了解肝损伤和修复的细胞和分子基础，PLRC带来了一群非常强大的调查员和临床医生从事基础和翻译的肝脏研究和在向肝脏患者提供临床护理时。在过去的两年中，PLRC汇集了会员资格由代表多个部门和 UP和UPMC中的机构作为一个社区。这是通过常规网络，物理学来准备的基础科学家圆桌会议，半小便和讲习班，以丰富环境，使其导电到加强现有的合作并启动新的伙伴关系。 PLRC已将自己组织成3个高度功能科学利益组（SIGS） - 再生医学，慢性肝病和肝脏肿瘤发生与重叠的成员资格和定期安排的相互作用，假装科学上的相互作用通过一个相当新颖的丰富计划进行对话的肥沃环境。 SIG圆桌会议允许重复出现医师和科学家在精心挑选的主题和促进合作等之间的对话等等有意义的研究。为了在PLRC调查人员的实验室中启用开拓和有影响力的科学，我们已经建立了3个高度综合的生物医学研究核心和一个提供最先进的临床成分以及创新的服务，以实现从长凳到床边的尖端研究和翻译。同样，PLRC 通过试点和可行性计划来确定新的调查人员，并支持他们的研究通过纵向心态和职业和专业人士作为独立研究人员的发展开发活动除了科学支持。通过机构支持的特别奖项允许资助团队科学项目促进物理和基础科学家互动，技术发展以及商业化。所有旨在辨别复杂磨难的上述服务和功能肝健康和疾病通过在肝胆损伤领域进行研究，并通过促进维修创新，协作式，跨学科和多学科研究，以对人类产生可持续的影响卫生是由行政核心的主持下提供的强大领导和组织确保的。实际上，PLRC领导层利用了该研究所的许多现有优势，例如CTSI，创新研究所以及库尔特计划以及与匹兹堡大学等现有机构建立联盟癌症研究所，Starzl移植研究所和McGowan再生医学研究所扩大 PLRC向所有成员提供的服务和利益，最终改善其科学，翻译和商业化。最终，通过他们的集成服务和计划，长期 PLRC的目的是在肝病病理生理领域促进有影响力的科学并改善肝健康和护理在本地和全球。