Pittsburgh Liver Research Center

匹兹堡肝脏研究中心

• 批准号: 10379013
• 负责人: Satdarshan Singh Monga
• 金额: $ 4.63万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-01 至 2022-03-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10379013
• 关键词: Academic Medical Centers; Administrative Supplement; Area; Award; Basic Science; Biology; Biomedical Research; Cells; Clinical; Collaborations; Communities; Complex; Comprehension; Core Facility; Development; Digestive System Disorders; Disease; Education; Educational workshop; Electronic Mail; Ensure; Environment; Equipment; Fostering; Functional disorder; Funding; Goals; Health; Healthcare; Hepatic; Hepatic Tissue; Hepatobiliary; Hepatocarcinogenesis; Hepatocyte; Human; Individual; Infrastructure; Institutes; Institution; Instruction; Interdisciplinary Study; Interest Group; Investigation; Leadership; Liver; Liver diseases; Medical center; Medicine; Mentors; Mentorship; Mission; Molecular; Pathology; Patients; Physicians; Process; Records; Regenerative Medicine; Research; Research Personnel; Resources; Schedule; Science; Scientist; Services; Technology; Time; Tissue Sample; Tissue imaging; Translations; Transplantation; Universities; University of Pittsburgh Cancer Institute; Wait Time; Work; base; bench to bedside; career; cellular imaging; chronic liver disease; clinical care; clinical practice; commercialization; cost; cryostat; environmental enrichment for laboratory animals; health care delivery; human disease; imaging facilities; improved; improved outcome; injury and repair; innovation; interdisciplinary collaboration; interest; member; multidisciplinary; next generation; novel; programs; prospective; recruit; research and development; response; service delivery; service programs; success; technology development

The inception of the Pittsburgh Liver Research Center (PLRC) in 2016 was the result of high enthusiasm of the leadership, which came with strong institutional support and commitment in the form of resources from both the University of Pittsburgh Medical Center (UPMC) and the University of Pittsburgh (UP). PLRC truly represents a successful partnership between UPMC, a pioneer in healthcare delivery and the UP, a renowned leader in research, discovery, education, and innovation. With the centralized mission of promoting the understanding of the cellular and molecular basis of hepatobiliary injury and repair, the PLRC has brought together a very strong group of investigators and clinicians engaged in basic and translational liver research and in the delivery of clinical care to liver patients. Over the last 2 years, PLRC has brought together the membership composed of 80 investigators and clinicians (49 full members) representing multiple departments and institutions within the UP and UPMC, as one community. This was facilitated by regular networking, physician- basic scientist roundtables, seminars and workshops, to enrich the environment making it conducive to strengthening existing collaborations and initiating new partnerships. PLRC has organized itself into 3 highly functional scientific interest groups (SIGs)−Regenerative Medicine, Chronic Liver Diseases, and Liver Tumorigenesis−with overlapping membership and regularly scheduled interactions facilitating a scientifically fertile environment for dialogue through a rather novel Enrichment program. SIG roundtables allow recurring dialogue between physicians and scientists on carefully selected topics and foster collaborations and more meaningful research. To enable pioneering and impactful science in the labs of PLRC investigators, we have established 3 highly integrated biomedical research cores and a clinical component that provide state-of-the-art and innovative services to enable cutting-edge research and translation from bench to bedside. Likewise, PLRC identifies new investigators and, through Pilot and Feasibility programs, supports their research and development as independent investigators through longitudinal mentorship and offering career and professional development activities in addition to scientific support. Special awards via institutional support allow funding of team science projects that promote physician and basic scientist interactions, technology development and commercialization. All of the above services and functions that are aimed at discerning complex tribulations in hepatic health and disease via research in the area of hepatobiliary injury and repair through promoting innovative, collaborative inter-, trans and multi-disciplinary research, to make a sustainable impact on human health, are ensured by a strong leadership and organization provided under the aegis of an Administrative Core. In fact, the PLRC leadership has leveraged many existing strengths of the institute like CTSI, Innovation Institute and the Coulter program as well as formed alliances with existing institutes like the University of Pittsburgh Cancer Institute, Starzl Transplant Institute and the McGowan Institute of Regenerative Medicine to expand services and benefits provided by the PLRC to all its members and eventually better their science, translation and commercialization. Thus, eventually, through their integrated services and programs, the long-term objective of the PLRC is to promote impactful science in the area of hepatobiliary pathophysiology and improve the hepatic health and care, both locally and globally.

匹兹堡肝脏研究中心（PLRC）于2016年成立，是由于 领导力，这伴随着强有力的机构支持和承诺， 匹兹堡大学医学中心（UPMC）和匹兹堡大学（UP）。PLRC真正 代表了UPMC，医疗保健服务的先驱和UP，一个著名的 研究、发现、教育和创新领域的领导者。其主要使命是促进 了解肝胆损伤和修复的细胞和分子基础，PLRC带来了 一个非常强大的研究人员和临床医生团队，从事基础和转化肝脏研究， 为肝病患者提供临床护理。在过去的两年里，PLRC汇集了成员 由代表多个部门的80名研究者和临床医生（49名正式成员）组成， UP和UPMC内部的机构，作为一个社区。这是由定期网络，医生促进- 基础科学家圆桌会议、研讨会和讲习班，以丰富环境， 加强现有的合作并建立新的伙伴关系。PLRC已组织成3个高度 功能科学兴趣小组（SIG）-再生医学，慢性肝病和肝脏 肿瘤发生-重叠的成员和定期安排的相互作用，促进科学的 通过一个相当新颖的丰富计划，为对话创造了肥沃的环境。SIG圆桌会议允许重复 医生和科学家之间就精心挑选的主题进行对话，促进合作等 有意义的研究。为了在PLRC研究人员的实验室中实现开创性和有影响力的科学，我们 建立了3个高度集成的生物医学研究核心和一个临床部分，提供最先进的 和创新的服务，使尖端的研究和翻译从板凳到床边。同样，PLRC 确定新的研究者，并通过试点和可行性计划，支持他们的研究， 通过纵向指导和提供职业和专业培训， 除了科学支持外，还有发展活动。通过机构支持提供的特别奖， 团队科学项目，促进医生和基础科学家的互动，技术开发， 商业化所有上述服务和功能，旨在识别复杂的磨难， 肝脏健康和疾病，通过研究肝胆损伤和修复领域，通过促进 创新，跨学科，跨学科和多学科合作研究，对人类产生可持续的影响 在一个行政核心的主持下，通过强有力的领导和组织来确保健康。 事实上，PLRC的领导层利用了该研究所的许多现有优势，如CTSI，创新研究所 和库尔特项目，以及与匹兹堡大学等现有研究所建立的联盟 癌症研究所，Starzl移植研究所和McGowan再生医学研究所将扩大 PLRC向所有成员提供的服务和福利，并最终改善他们的科学，翻译， 和商业化。因此，最终，通过他们的综合服务和方案， PLRC的目标是促进肝胆病理生理学领域的有效科学， 肝脏健康和护理，无论是在当地还是全球。