Pittsburgh Liver Research Center

匹兹堡肝脏研究中心(PLRC)于2016年成立，是人们高度热情的结果 领导力，来自两国的强有力的机构支持和资源承诺 匹兹堡大学医学中心(UPMC)和匹兹堡大学(UP)。PLRC True 代表着UPMC和UP之间的成功合作伙伴关系，UPMC是医疗保健提供的先驱，UP是著名的 在研究、发现、教育和创新方面处于领先地位。其中心使命是推动 对肝胆损伤和修复的细胞和分子基础的理解，PLRC带来了 一群非常强大的研究人员和临床医生共同从事基础和转化性肝脏研究 为肝病患者提供临床护理。在过去的两年里，PLRC将成员聚集在一起 由80名研究人员和临床医生(49名正式成员)组成，代表多个部门和 UP和UPMC内部的机构，作为一个社区。这是由定期的网络促进的，医生- 基本科学家圆桌会议、研讨会和讲习班，以丰富环境，使之有利于 加强现有合作并启动新的伙伴关系。PLRC将自己组织成3个高度 功能科学兴趣小组(SIG)−再生医学、慢性肝病和肝脏 肿瘤发生−具有重叠的成员和定期安排的相互作用，促进了科学 通过一个相当新颖的丰富计划，为对话创造了肥沃的环境。签名圆桌会议允许反复举行 医生和科学家就精心挑选的主题进行对话，促进合作等 有意义的研究。为了在PLRC调查人员的实验室中实现开创性和有影响力的科学，我们有 建立了3个高度集成的生物医学研究核心和一个临床组件，提供最先进的 以及创新服务，实现从长凳到床边的尖端研究和翻译。同样，PLRC 确定新的调查人员，并通过试点和可行性计划支持他们的研究和 通过纵向指导和提供职业和专业知识，发展成为独立调查人员 除科学支持外，还将开展发展活动。通过机构支持的特别奖项允许为 团队科学项目，促进医生和基础科学家的互动，技术开发和 商业化。所有上述旨在识别复杂磨难的服务和功能 通过促进肝胆损伤和修复领域的研究来促进肝脏健康和疾病 创新、协作的跨学科、跨学科和多学科研究，对人类产生可持续的影响 在行政核心的主持下，由强有力的领导和组织来确保。 事实上，PLRC领导层已经利用了该研究所的许多现有优势，如CTSI、创新研究所 以及库尔特计划以及与匹兹堡大学等现有机构的联盟 癌症研究所、Starzl移植研究所和McGowan再生医学研究所将扩大 PLRC为其所有成员提供的服务和好处，并最终改善他们的科学、翻译 和商业化。因此，最终，通过他们的综合服务和计划，长期 PLRC的目标是促进肝胆病理生理学领域的有影响力的科学并改进 本地和全球的肝脏健康和护理。

The inception of the Pittsburgh Liver Research Center (PLRC) in 2016 was the result of high enthusiasm of the leadership, which came with strong institutional support and commitment in the form of resources from both the University of Pittsburgh Medical Center (UPMC) and the University of Pittsburgh (UP). PLRC truly represents a successful partnership between UPMC, a pioneer in healthcare delivery and the UP, a renowned leader in research, discovery, education, and innovation. With the centralized mission of promoting the understanding of the cellular and molecular basis of hepatobiliary injury and repair, the PLRC has brought together a very strong group of investigators and clinicians engaged in basic and translational liver research and in the delivery of clinical care to liver patients. Over the last 2 years, PLRC has brought together the membership composed of 80 investigators and clinicians (49 full members) representing multiple departments and institutions within the UP and UPMC, as one community. This was facilitated by regular networking, physician- basic scientist roundtables, seminars and workshops, to enrich the environment making it conducive to strengthening existing collaborations and initiating new partnerships. PLRC has organized itself into 3 highly functional scientific interest groups (SIGs)−Regenerative Medicine, Chronic Liver Diseases, and Liver Tumorigenesis−with overlapping membership and regularly scheduled interactions facilitating a scientifically fertile environment for dialogue through a rather novel Enrichment program. SIG roundtables allow recurring dialogue between physicians and scientists on carefully selected topics and foster collaborations and more meaningful research. To enable pioneering and impactful science in the labs of PLRC investigators, we have established 3 highly integrated biomedical research cores and a clinical component that provide state-of-the-art and innovative services to enable cutting-edge research and translation from bench to bedside. Likewise, PLRC identifies new investigators and, through Pilot and Feasibility programs, supports their research and development as independent investigators through longitudinal mentorship and offering career and professional development activities in addition to scientific support. Special awards via institutional support allow funding of team science projects that promote physician and basic scientist interactions, technology development and commercialization. All of the above services and functions that are aimed at discerning complex tribulations in hepatic health and disease via research in the area of hepatobiliary injury and repair through promoting innovative, collaborative inter-, trans and multi-disciplinary research, to make a sustainable impact on human health, are ensured by a strong leadership and organization provided under the aegis of an Administrative Core. In fact, the PLRC leadership has leveraged many existing strengths of the institute like CTSI, Innovation Institute and the Coulter program as well as formed alliances with existing institutes like the University of Pittsburgh Cancer Institute, Starzl Transplant Institute and the McGowan Institute of Regenerative Medicine to expand services and benefits provided by the PLRC to all its members and eventually better their science, translation and commercialization. Thus, eventually, through their integrated services and programs, the long-term objective of the PLRC is to promote impactful science in the area of hepatobiliary pathophysiology and improve the hepatic health and care, both locally and globally.