Pittsburgh Liver Research Center

匹兹堡肝脏研究中心

• 批准号: 10589759
• 负责人: Satdarshan Singh Monga
• 金额: $ 117.06万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10589759
• 关键词: Area; Award; Basic Science; Biomedical Research; Caring; Categories; Clinical; Collaborations; Communities; Complex; Comprehension; Continuing Education; Core Facility; Development; Disease; Education; Educational workshop; Ensure; Environment; Experimental Models; Fostering; Functional disorder; Funding; Goals; Health; Hepatic; Hepatobiliary; Hepatocarcinogenesis; Human; Individual; Infrastructure; Institution; Instruction; Interdisciplinary Study; Interest Group; Investigation; Investments; Leadership; Liver; Liver diseases; Medical center; Medicine; Mentors; Mentorship; Mission; Molecular; Molecular Target; Outcome; Pathology; Patients; Physicians; Process; Records; Recurrence; Regenerative Medicine; Research; Research Personnel; Resources; Sampling; Schedule; Science; Scientist; Services; Translating; Translational Research; Translations; Transplantation; Universities; University of Pittsburgh Cancer Institute; base; bench-to-bedside translation; biomarker discovery; burden of illness; career; chronic liver disease; clinical care; clinical practice; commercialization; data integration; diagnostic biomarker; environmental enrichment for laboratory animals; health care delivery; human data; improved; improved outcome; injury and repair; innovation; interdisciplinary collaboration; interest; member; multidisciplinary; next generation; novel; programs; prospective; recruit; research and development; special interest group; synergism; technology development

Abstract The inception of the Pittsburgh Liver Research Center (PLRC) in 2016 was the result of high enthusiasm of the leadership, which came with strong institutional support and commitment in the form of resources from both the University of Pittsburgh Medical Center (UPMC) and the University of Pittsburgh (UP). PLRC truly represents a successful partnership between UPMC, a pioneer in healthcare delivery and the UP, a renowned leader in research, discovery, education, and innovation. With the centralized mission of promoting the understanding of the cellular and molecular basis of hepatobiliary injury and repair, the PLRC has brought together a very strong group of investigators and clinicians engaged in basic and translational liver research and in the delivery of clinical care to liver patients. Over the last 2 years, PLRC has brought together the membership composed of 80 investigators and clinicians (49 full members) representing multiple departments and institutions within the UP and UPMC, as one community. This was facilitated by regular networking, physician-basic scientist roundtables, seminars and workshops, to enrich the environment making it conducive to strengthening existing collaborations and initiating new partnerships. PLRC has organized itself into 3 highly functional scientific interest groups (SIGs)−Regenerative Medicine, Chronic Liver Diseases, and Liver Tumorigenesis−with overlapping membership and regularly scheduled interactions facilitating a scientifically fertile environment for dialogue through a rather novel Enrichment program. SIG roundtables allow recurring dialogue between physicians and scientists on carefully selected topics and foster collaborations and more meaningful research. To enable pioneering and impactful science in the labs of PLRC investigators, we have established 3 highly integrated biomedical research cores and a clinical component that provide state-of-the-art and innovative services to enable cutting- edge research and translation from bench to bedside. Likewise, PLRC identifies new investigators and, through Pilot and Feasibility programs, supports their research and development as independent investigators through longitudinal mentorship and offering career and professional development activities in addition to scientific support. Special awards via institutional support allow funding of team science projects that promote physician and basic scientist interactions, technology development and commercialization. All of the above services and functions that are aimed at discerning complex tribulations in hepatic health and disease via research in the area of hepatobiliary injury and repair through promoting innovative, collaborative inter-, trans and multi-disciplinary research, to make a sustainable impact on human health, are ensured by a strong leadership and organization provided under the aegis of an Administrative Core. In fact, the PLRC leadership has leveraged many existing strengths of the institute like CTSI, Innovation Institute and the Coulter program as well as formed alliances with existing institutes like the University of Pittsburgh Cancer Institute, Starzl Transplant Institute and the McGowan Institute of Regenerative Medicine to expand services and benefits provided by the PLRC to all its members and eventually better their science, translation and commercialization. Thus, eventually, through their integrated services and programs, the long-term objective of the PLRC is to promote impactful science in the area of hepatobiliary pathophysiology and improve the hepatic health and care, both locally and globally.

摘要 匹兹堡肝脏研究中心（PLRC）于2016年成立，是由于 领导，这是由强有力的机构支持和承诺，其形式是来自两个组织的资源， 匹兹堡大学医学中心（UPMC）和匹兹堡大学（UP）。PLRC真正代表了一个 UPMC是医疗保健服务的先驱，UP是研究领域的知名领导者， 发现、教育和创新。其中心使命是促进对细胞和 肝胆损伤和修复的分子基础，PLRC汇集了一批非常强大的研究人员 以及从事基础和转化肝脏研究以及为肝脏患者提供临床护理的临床医生。超过 在过去的2年里，PLRC汇集了80名研究人员和临床医生组成的成员（49名全 成员）代表UP和UPMC内的多个部门和机构，作为一个社区。这是 通过定期联网、医生-基础科学家圆桌会议、研讨会和讲习班， 环境，使其有利于加强现有的合作和发起新的伙伴关系。PLRC有 将自己组织成3个高度功能性的科学兴趣小组（SIG）-再生医学，慢性肝病， 和肝肿瘤发生-重叠的成员和定期安排的相互作用，促进科学的 通过一个相当新颖的丰富计划，为对话创造了肥沃的环境。SIG圆桌会议允许经常性对话 在医生和科学家之间就精心挑选的主题进行合作，促进合作和更有意义的研究。到 在PLRC研究人员的实验室中实现开拓性和有影响力的科学，我们已经建立了3个高度集成的 生物医学研究核心和临床组件，提供最先进的和创新的服务，使切割- 边缘研究和从实验室到床边的翻译。同样，PLRC确定新的调查人员，并通过试点和 可行性计划，支持他们的研究和发展作为独立的调查员，通过纵向 除了科学支持外，还提供辅导和职业和专业发展活动。特别奖 通过机构支持，允许资助促进医生和基础科学家互动的团队科学项目， 技术开发和商业化。上述所有服务和功能旨在识别 通过肝胆损伤和修复领域的研究， 促进创新，跨学科，跨学科和多学科的合作研究，对人类产生可持续的影响 在一个行政核心的主持下，通过强有力的领导和组织来确保健康。事实上， PLRC的领导层利用了CTSI、创新研究所和库尔特研究所等研究所的许多现有优势 该计划以及与匹兹堡大学癌症研究所，Starzl 移植研究所和麦高恩再生医学研究所，以扩大服务和福利提供的 PLRC向其所有成员，并最终改善他们的科学，翻译和商业化。最终，通过 他们的综合服务和计划，PLRC的长期目标是促进有影响力的科学领域， 肝胆病理生理学和改善肝脏的健康和护理，无论是在当地和全球。