Pittsburgh Liver Research Center

匹兹堡肝脏研究中心

• 批准号: 10589759
• 负责人: Satdarshan Singh Monga
• 金额: $ 117.06万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10589759
• 关键词: Area; Award; Basic Science; Biomedical Research; Caring; Categories; Clinical; Collaborations; Communities; Complex; Comprehension; Continuing Education; Core Facility; Development; Disease; Education; Educational workshop; Ensure; Environment; Experimental Models; Fostering; Functional disorder; Funding; Goals; Health; Hepatic; Hepatobiliary; Hepatocarcinogenesis; Human; Individual; Infrastructure; Institution; Instruction; Interdisciplinary Study; Interest Group; Investigation; Investments; Leadership; Liver; Liver diseases; Medical center; Medicine; Mentors; Mentorship; Mission; Molecular; Molecular Target; Outcome; Pathology; Patients; Physicians; Process; Records; Recurrence; Regenerative Medicine; Research; Research Personnel; Resources; Sampling; Schedule; Science; Scientist; Services; Translating; Translational Research; Translations; Transplantation; Universities; University of Pittsburgh Cancer Institute; base; bench-to-bedside translation; biomarker discovery; burden of illness; career; chronic liver disease; clinical care; clinical practice; commercialization; data integration; diagnostic biomarker; environmental enrichment for laboratory animals; health care delivery; human data; improved; improved outcome; injury and repair; innovation; interdisciplinary collaboration; interest; member; multidisciplinary; next generation; novel; programs; prospective; recruit; research and development; special interest group; synergism; technology development

Abstract The inception of the Pittsburgh Liver Research Center (PLRC) in 2016 was the result of high enthusiasm of the leadership, which came with strong institutional support and commitment in the form of resources from both the University of Pittsburgh Medical Center (UPMC) and the University of Pittsburgh (UP). PLRC truly represents a successful partnership between UPMC, a pioneer in healthcare delivery and the UP, a renowned leader in research, discovery, education, and innovation. With the centralized mission of promoting the understanding of the cellular and molecular basis of hepatobiliary injury and repair, the PLRC has brought together a very strong group of investigators and clinicians engaged in basic and translational liver research and in the delivery of clinical care to liver patients. Over the last 2 years, PLRC has brought together the membership composed of 80 investigators and clinicians (49 full members) representing multiple departments and institutions within the UP and UPMC, as one community. This was facilitated by regular networking, physician-basic scientist roundtables, seminars and workshops, to enrich the environment making it conducive to strengthening existing collaborations and initiating new partnerships. PLRC has organized itself into 3 highly functional scientific interest groups (SIGs)−Regenerative Medicine, Chronic Liver Diseases, and Liver Tumorigenesis−with overlapping membership and regularly scheduled interactions facilitating a scientifically fertile environment for dialogue through a rather novel Enrichment program. SIG roundtables allow recurring dialogue between physicians and scientists on carefully selected topics and foster collaborations and more meaningful research. To enable pioneering and impactful science in the labs of PLRC investigators, we have established 3 highly integrated biomedical research cores and a clinical component that provide state-of-the-art and innovative services to enable cutting- edge research and translation from bench to bedside. Likewise, PLRC identifies new investigators and, through Pilot and Feasibility programs, supports their research and development as independent investigators through longitudinal mentorship and offering career and professional development activities in addition to scientific support. Special awards via institutional support allow funding of team science projects that promote physician and basic scientist interactions, technology development and commercialization. All of the above services and functions that are aimed at discerning complex tribulations in hepatic health and disease via research in the area of hepatobiliary injury and repair through promoting innovative, collaborative inter-, trans and multi-disciplinary research, to make a sustainable impact on human health, are ensured by a strong leadership and organization provided under the aegis of an Administrative Core. In fact, the PLRC leadership has leveraged many existing strengths of the institute like CTSI, Innovation Institute and the Coulter program as well as formed alliances with existing institutes like the University of Pittsburgh Cancer Institute, Starzl Transplant Institute and the McGowan Institute of Regenerative Medicine to expand services and benefits provided by the PLRC to all its members and eventually better their science, translation and commercialization. Thus, eventually, through their integrated services and programs, the long-term objective of the PLRC is to promote impactful science in the area of hepatobiliary pathophysiology and improve the hepatic health and care, both locally and globally.

抽象的 匹兹堡肝脏研究中心 (PLRC) 于 2016 年成立，是大家高度热情的结果。 领导力，这来自于双方以资源形式提供的强有力的机构支持和承诺 匹兹堡大学医学中心 (UPMC) 和匹兹堡大学 (UP)。 PLRC真正代表了 医疗保健领域的先驱 UPMC 与研究领域的知名领导者 UP 之间的成功合作伙伴关系， 发现、教育和创新。以促进对细胞和细胞的理解为中心使命 肝胆损伤和修复的分子基础，PLRC 聚集了一支非常强大的研究人员团队 从事基础和转化肝脏研究以及为肝脏患者提供临床护理的临床医生。超过 在过去的两年里，PLRC 汇集了由 80 名研究人员和临床医生组成的会员（其中 49 名是全职 成员）代表 UP 和 UPMC 内的多个部门和机构，作为一个社区。这是 通过定期网络、医师-基础科学家圆桌会议、研讨会和讲习班来促进，以丰富 有利于加强现有合作和建立新伙伴关系的环境。 PLRC 有 组织成 3 个功能强大的科学兴趣小组 (SIG)——再生医学、慢性肝病、 和肝脏肿瘤发生——具有重叠的成员资格和定期安排的互动，促进科学的研究 通过相当新颖的强化计划为对话创造了肥沃的环境。 SIG 圆桌会议允许反复对话 医生和科学家之间就精心挑选的主题进行交流，并促进合作和更有意义的研究。到 为了在 PLRC 研究人员的实验室中实现开创性和有影响力的科学，我们建立了 3 个高度集成的实验室 生物医学研究核心和临床部分提供最先进的创新服务，以实现切割- 从实验室到临床的边缘研究和转化。同样，PLRC 确定了新的调查员，并通过试点和 可行性计划，通过纵向支持他们作为独立研究者的研究和开发 除科​​学支持外，还提供指导并提供职业和专业发展活动。特别奖 通过机构支持，为促进医生和基础科学家互动的团队科学项目提供资金， 技术开发和商业化。以上所有的服务和功能都是为了有眼光的人 通过肝胆损伤和修复领域的研究，了解肝脏健康和疾病的复杂磨难 促进创新、协作的跨学科、跨学科和多学科研究，对人类产生可持续的影响 在行政核心的支持下，强有力的领导和组织确保了健康。实际上， PLRC 领导层利用了该研究所的许多现有优势，如 CTSI、创新研究所和库尔特 计划并与匹兹堡大学癌症研究所、Starzl 等现有机构结成联盟 移植研究所和麦高恩再生医学研究所扩大移植研究所提供的服务和福利 PLRC 向其所有成员提供帮助，并最终改善他们的科学、翻译和商业化。因此，最终通过 通过其综合服务和项目，PLRC 的长期目标是促进以下领域有影响力的科学 肝胆病理生理学并改善本地和全球的肝脏健康和护理。