Pittsburgh Liver Research Center

匹兹堡肝脏研究中心

• 批准号: 10372007
• 负责人: Satdarshan Singh Monga
• 金额: $ 117.06万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10372007
• 关键词: Academic Medical Centers; Area; Award; Basic Science; Biomedical Research; Clinical; Collaborations; Communities; Complex; Comprehension; Continuing Education; Core Facility; Development; Disease; Education; Educational workshop; Ensure; Environment; Experimental Models; Fostering; Functional disorder; Funding; Goals; Health; Healthcare; Hepatic; Hepatobiliary; Hepatocarcinogenesis; Human; Individual; Infrastructure; Institutes; Institution; Instruction; Interdisciplinary Study; Interest Group; Investigation; Leadership; Liver; Liver diseases; Medical center; Medicine; Mentors; Mentorship; Mission; Molecular; Molecular Target; Outcome; Pathology; Patients; Physicians; Process; Records; Regenerative Medicine; Research; Research Personnel; Resources; Sampling; Schedule; Science; Scientist; Services; Time; Translating; Translational Research; Translations; Transplantation; Universities; University of Pittsburgh Cancer Institute; base; bench-to-bedside translation; biomarker discovery; burden of illness; career; chronic liver disease; clinical care; clinical practice; commercialization; diagnostic biomarker; environmental enrichment for laboratory animals; health care delivery; human data; improved; improved outcome; injury and repair; innovation; interdisciplinary collaboration; interest; member; multidisciplinary; next generation; novel; programs; prospective; recruit; research and development; service programs; special interest group; technology development

Abstract The inception of the Pittsburgh Liver Research Center (PLRC) in 2016 was the result of high enthusiasm of the leadership, which came with strong institutional support and commitment in the form of resources from both the University of Pittsburgh Medical Center (UPMC) and the University of Pittsburgh (UP). PLRC truly represents a successful partnership between UPMC, a pioneer in healthcare delivery and the UP, a renowned leader in research, discovery, education, and innovation. With the centralized mission of promoting the understanding of the cellular and molecular basis of hepatobiliary injury and repair, the PLRC has brought together a very strong group of investigators and clinicians engaged in basic and translational liver research and in the delivery of clinical care to liver patients. Over the last 2 years, PLRC has brought together the membership composed of 80 investigators and clinicians (49 full members) representing multiple departments and institutions within the UP and UPMC, as one community. This was facilitated by regular networking, physician-basic scientist roundtables, seminars and workshops, to enrich the environment making it conducive to strengthening existing collaborations and initiating new partnerships. PLRC has organized itself into 3 highly functional scientific interest groups (SIGs)−Regenerative Medicine, Chronic Liver Diseases, and Liver Tumorigenesis−with overlapping membership and regularly scheduled interactions facilitating a scientifically fertile environment for dialogue through a rather novel Enrichment program. SIG roundtables allow recurring dialogue between physicians and scientists on carefully selected topics and foster collaborations and more meaningful research. To enable pioneering and impactful science in the labs of PLRC investigators, we have established 3 highly integrated biomedical research cores and a clinical component that provide state-of-the-art and innovative services to enable cutting- edge research and translation from bench to bedside. Likewise, PLRC identifies new investigators and, through Pilot and Feasibility programs, supports their research and development as independent investigators through longitudinal mentorship and offering career and professional development activities in addition to scientific support. Special awards via institutional support allow funding of team science projects that promote physician and basic scientist interactions, technology development and commercialization. All of the above services and functions that are aimed at discerning complex tribulations in hepatic health and disease via research in the area of hepatobiliary injury and repair through promoting innovative, collaborative inter-, trans and multi-disciplinary research, to make a sustainable impact on human health, are ensured by a strong leadership and organization provided under the aegis of an Administrative Core. In fact, the PLRC leadership has leveraged many existing strengths of the institute like CTSI, Innovation Institute and the Coulter program as well as formed alliances with existing institutes like the University of Pittsburgh Cancer Institute, Starzl Transplant Institute and the McGowan Institute of Regenerative Medicine to expand services and benefits provided by the PLRC to all its members and eventually better their science, translation and commercialization. Thus, eventually, through their integrated services and programs, the long-term objective of the PLRC is to promote impactful science in the area of hepatobiliary pathophysiology and improve the hepatic health and care, both locally and globally.

摘要 匹兹堡肝脏研究中心(PLRC)于2016年成立，是人们高度热情的结果 领导力，来自两个国家的强有力的机构支持和资源承诺 匹兹堡大学医学中心(UPMC)和匹兹堡大学(UP)。PLRC真正代表了一种 UPMC是医疗保健提供的先驱，UP是著名的研究领先者， 发现、教育和创新。其中心使命是促进对细胞和 关于肝胆损伤和修复的分子基础，PLRC召集了一支非常强大的研究小组 以及从事基础和转化性肝脏研究以及为肝脏患者提供临床护理的临床医生。完毕 在过去的两年中，PLRC汇集了由80名研究人员和临床医生(49名)组成的成员 成员)，代表UP和UPMC内的多个部门和机构，作为一个社区。这是 通过定期建立联系、医生-基础科学家圆桌会议、研讨会和讲习班，丰富 环境使之有利于加强现有的合作和启动新的伙伴关系。PLRC已经 组织成3个功能强大的科学兴趣小组(SIG)：−再生医学、慢性肝病、 和肝肿瘤发生−有重叠的成员和定期安排的互动促进科学 通过一个相当新颖的丰富计划，为对话创造了肥沃的环境。Sig型圆桌会议允许重复对话 医生和科学家之间就精心挑选的主题进行合作，促进合作和更有意义的研究。至 在PLRC研究人员的实验室中支持先锋和有影响力的科学，我们已经建立了3个高度集成的 生物医学研究核心和临床组件，提供最先进和创新的服务，使切割- 从板凳到床边的边缘研究和翻译。同样，PLRC确定了新的调查人员，并通过Pilot和 可行性计划，通过纵向支持他们作为独立调查人员的研发 除了科学支持外，还提供职业指导和职业发展活动。特别奖 通过机构支持，允许为促进医生和基础科学家互动的团队科学项目提供资金， 技术开发和商业化。以上所有服务和功能旨在辨别 通过对肝胆损伤和修复领域的研究，对肝脏健康和疾病的复杂磨难 促进创新、协作的跨学科、跨学科和多学科研究，对人类产生可持续的影响 在行政核心的主持下，由强有力的领导和组织来确保。事实上, PLRC领导层利用了该研究所的许多现有优势，如CTSI、创新研究所和库尔特 计划以及与匹兹堡大学癌症研究所、Starzl等现有研究所结成联盟 移植研究所和McGowan再生医学研究所扩大由 PLRC的所有成员，并最终更好地他们的科学，翻译和商业化。因此，最终，通过 他们的综合服务和计划，PLRC的长期目标是促进在以下领域的有影响力的科学 肝胆病理生理学和改善肝脏的健康和护理，无论是在当地还是全球。