Pittsburgh Liver Research Center

匹兹堡肝脏研究中心

• 批准号: 10372007
• 负责人: Satdarshan Singh Monga
• 金额: $ 117.06万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10372007
• 关键词: Academic Medical Centers; Area; Award; Basic Science; Biomedical Research; Clinical; Collaborations; Communities; Complex; Comprehension; Continuing Education; Core Facility; Development; Disease; Education; Educational workshop; Ensure; Environment; Experimental Models; Fostering; Functional disorder; Funding; Goals; Health; Healthcare; Hepatic; Hepatobiliary; Hepatocarcinogenesis; Human; Individual; Infrastructure; Institutes; Institution; Instruction; Interdisciplinary Study; Interest Group; Investigation; Leadership; Liver; Liver diseases; Medical center; Medicine; Mentors; Mentorship; Mission; Molecular; Molecular Target; Outcome; Pathology; Patients; Physicians; Process; Records; Regenerative Medicine; Research; Research Personnel; Resources; Sampling; Schedule; Science; Scientist; Services; Time; Translating; Translational Research; Translations; Transplantation; Universities; University of Pittsburgh Cancer Institute; base; bench-to-bedside translation; biomarker discovery; burden of illness; career; chronic liver disease; clinical care; clinical practice; commercialization; diagnostic biomarker; environmental enrichment for laboratory animals; health care delivery; human data; improved; improved outcome; injury and repair; innovation; interdisciplinary collaboration; interest; member; multidisciplinary; next generation; novel; programs; prospective; recruit; research and development; service programs; special interest group; technology development

Abstract The inception of the Pittsburgh Liver Research Center (PLRC) in 2016 was the result of high enthusiasm of the leadership, which came with strong institutional support and commitment in the form of resources from both the University of Pittsburgh Medical Center (UPMC) and the University of Pittsburgh (UP). PLRC truly represents a successful partnership between UPMC, a pioneer in healthcare delivery and the UP, a renowned leader in research, discovery, education, and innovation. With the centralized mission of promoting the understanding of the cellular and molecular basis of hepatobiliary injury and repair, the PLRC has brought together a very strong group of investigators and clinicians engaged in basic and translational liver research and in the delivery of clinical care to liver patients. Over the last 2 years, PLRC has brought together the membership composed of 80 investigators and clinicians (49 full members) representing multiple departments and institutions within the UP and UPMC, as one community. This was facilitated by regular networking, physician-basic scientist roundtables, seminars and workshops, to enrich the environment making it conducive to strengthening existing collaborations and initiating new partnerships. PLRC has organized itself into 3 highly functional scientific interest groups (SIGs)−Regenerative Medicine, Chronic Liver Diseases, and Liver Tumorigenesis−with overlapping membership and regularly scheduled interactions facilitating a scientifically fertile environment for dialogue through a rather novel Enrichment program. SIG roundtables allow recurring dialogue between physicians and scientists on carefully selected topics and foster collaborations and more meaningful research. To enable pioneering and impactful science in the labs of PLRC investigators, we have established 3 highly integrated biomedical research cores and a clinical component that provide state-of-the-art and innovative services to enable cutting- edge research and translation from bench to bedside. Likewise, PLRC identifies new investigators and, through Pilot and Feasibility programs, supports their research and development as independent investigators through longitudinal mentorship and offering career and professional development activities in addition to scientific support. Special awards via institutional support allow funding of team science projects that promote physician and basic scientist interactions, technology development and commercialization. All of the above services and functions that are aimed at discerning complex tribulations in hepatic health and disease via research in the area of hepatobiliary injury and repair through promoting innovative, collaborative inter-, trans and multi-disciplinary research, to make a sustainable impact on human health, are ensured by a strong leadership and organization provided under the aegis of an Administrative Core. In fact, the PLRC leadership has leveraged many existing strengths of the institute like CTSI, Innovation Institute and the Coulter program as well as formed alliances with existing institutes like the University of Pittsburgh Cancer Institute, Starzl Transplant Institute and the McGowan Institute of Regenerative Medicine to expand services and benefits provided by the PLRC to all its members and eventually better their science, translation and commercialization. Thus, eventually, through their integrated services and programs, the long-term objective of the PLRC is to promote impactful science in the area of hepatobiliary pathophysiology and improve the hepatic health and care, both locally and globally.

抽象的 2016年匹兹堡肝脏研究中心（PLRC）的诞生是高热情的结果 领导力，以资源的形式得到了强有力的机构支持和承诺 匹兹堡大学医学中心（UPMC）和匹兹堡大学（UP）。 PLRC确实代表了 医疗保健提供的先驱与UP的成功合作伙伴关系，UP，著名的研究领导者， 发现，教育和创新。促进对细胞和细胞的理解的集中任务 PLRC的分子基础肝损伤和修复，将一组非常强大的研究者汇集在一起 临床医生从事基本和翻译的肝脏研究以及向肝脏患者提供临床护理。超过 在过去的两年中，PLRC汇集了由80位调查员和临床医生组成的会员资格（49位满 成员）代表UP和UPMC中多个部门和机构作为一个社区。这是 由常规网络，物理基础科学家圆桌会议，半小便和讲习班准备，以丰富 环境使加强现有合作并启动新的合作伙伴关系的环境。 PLRC有 组织自己分为3个高度功能的科学利益群体（SIGS） - 再生医学，慢性肝脏疾病， 以及与成员重叠的肝肿瘤发生，并定期安排的互动促进科学上的促进 通过一个相当新颖的丰富计划进行对话的肥沃环境。 SIG圆桌会议允许重复对话 医师和科学家在精心挑选的主题和培养合作以及更有意义的研究之间进行研究。到 在PLRC调查人员的实验室中启用开拓性和有影响力的科学，我们已经建立了3个高度整合的 生物医学研究核心和提供最先进和创新服务的临床成分，以实现削减 边缘研究和翻译从长凳到床边。同样，PLRC确定了新的调查人员，并通过飞行员和 可行性计划，通过纵向支持他们作为独立研究人员的研究和发展 除了科学支持之外，资态和提供职业和专业发展活动。特别奖项 通过机构支持，可以为促进身体和基础科学家互动的团队科学项目提供资金， 技术开发和商业化。旨在辨别的所有上述服务和功能 肝健康和疾病中的复杂磨难是通过在肝病损伤领域进行的研究 促进创新的，合作的间，跨性别和多学科研究，以对人类产生可持续的影响 卫生是由行政核心的主持下提供的强大领导和组织确保的。实际上， PLRC领导层利用了CTSI，Innovation Institute和Coulter等研究所的许多现有优势 计划以及与匹兹堡大学癌症研究所等现有机构建立联盟 移植研究所和麦高万再生医学研究所，以扩大由 PLRC向所有成员提供，并最终改善其科学，翻译和商业化。最终，通过 他们的综合服务和计划，PLRC的长期目标是在该领域促进有影响力的科学 肝胆病理生理学并改善本地和全球的肝健康和护理。