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• 批准号: 10819463
• 负责人: LEONARD FREEDMAN
• 金额: $ 20.17万
• 依托单位: LEIDOS BIOMEDICAL RESEARCH, INC.
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-31 至 2023-08-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10819463
• 关键词: Academia; Cancer Center; Cancer Model; Catalogs; Clinical; Communities; Data; Data Sources; Foundations; Genomic Data Commons; Genomics; Goals; Human; In Vitro; Institution; Intellectual Property; International; Libraries; Malignant Neoplasms; Methods; Modeling; Molecular; National Cancer Institute; Office of Cancer Genomics; Online Systems; Organoids; Research Personnel; Resources; Source; System; Technology; Tissue Donors; Trust; anticancer research; biopharmaceutical industry; cancer genomics; clinical diagnostics; data modeling; interest; member; model development; next generation; novel; query tools; response

Systematic application of novel culture methods now presents an opportunity to develop a large library of cancer models that can be made available as a community resource to investigators in academia and the biopharmaceutical industry. In response to the opportunity, the National Cancer Institute’s (NCI) Office of Cancer Genomics (OCG), in the Center for Cancer Genomics (CCG), together with international institutions, has established a consortium, the Human Cancer Models Initiative (HCMI). HCMI’s goal is to make available to the scientific community large numbers of “next generation” in vitro cancer models that are not encumbered with excessive intellectual property (IP) constraints. To support the US contribution to HCMI, OCG established four Cancer Model Development Centers (CMDCs). The other founding HCMI collaborators are Cancer Research UK (CRUK), Wellcome Trust Sanger Institute (WTSI), and the Hubrecht Organoid Technology foundation (HUB).

新的培养方法的系统应用现在为开发大型癌症模型库提供了机会，这些模型库可以作为学术界和生物制药行业研究人员的社区资源。为了应对这一机遇，美国国家癌症研究所（NCI）癌症基因组学办公室（OCG）在癌症基因组学中心（CCG）与国际机构一起建立了一个联盟，即人类癌症模型倡议（HCMI）。HCMI的目标是为科学界提供大量的“下一代”体外癌症模型，这些模型不会受到过多的知识产权（IP）限制。为了支持美国对HCMI的贡献，OCG建立了四个癌症模型开发中心（CMDC）。其他创始HCMI合作者是英国癌症研究中心（CRUK），威康信托桑格研究所（WTSI）和Hubrecht类器官技术基金会（HUB）。