CHILDHOOD CANCER SURVIVOR STUDY

儿童癌症幸存者研究

• 批准号: 10844314
• 负责人: Gregory Armstrong
• 金额: $ 137.07万
• 依托单位: ST. JUDE CHILDREN'S RESEARCH HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-01 至 2026-11-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10844314
• 关键词: Address; Adolescent; Child; Childhood; Childhood Cancer Survivor Study; Cohort Studies; DNA sequencing; Data; Diagnosis; Disease susceptibility; Eligibility Determination; Genetic Predisposition to Disease; Genotype; Health; Institution; Intervention; Investigation; Late Effects; Malignant Childhood Neoplasm; Malignant Neoplasms; Methylation; Morbidity - disease rate; Outcome; Participant; Publications; Quality of life; Research; Research Personnel; Resources; Risk; SNP array; Source; Survival Rate; Survivors; biobank; childhood cancer survivor; cohort; follow-up; health related quality of life; high risk population; improved; mortality; multidisciplinary; recruit; screening guidelines; survivorship

ABSTRACT The Childhood Cancer Survivor Study (CCSS) is a multi-institutional, multi-disciplinary collaborative research resource established to systematically evaluate long-term outcomes among children diagnosed with cancer who survived five or more years from diagnosis. With the successful recruitment and longitudinal follow-up of the cohort that includes survivors diagnosed and treated over three decades (1970-1999), the CCSS is the world’s largest established open resource for survivorship research with 38,036 eligible survivors available for investigation of late mortality, and 25,665 participants who have contributed health-related and quality of life outcomes. The resource includes comprehensive annotation of treatment exposures, ongoing longitudinal follow-up and an established biorepository from which genotype (SNP array) and DNA sequencing of 8,380 survivors are available to investigators for identification of genetic susceptibility for disease- and treatment- related late effects. The current supplement application will expand the resource to provide methylation profiling data for more than 2,800 participants.

摘要 儿童癌症幸存者研究（CCSS）是一项多机构、多学科的合作研究 建立资源系统地评估诊断患有癌症的儿童的长期结果 在确诊后存活了五年或更长时间。随着成功招募和纵向随访， 该队列包括三十年（1970-1999）诊断和治疗的幸存者，CCSS是 世界上最大的幸存者研究开放资源，有38，036名合格的幸存者可供使用， 对晚期死亡率的调查，以及25，665名参与者对健康相关和生活质量的贡献 结果。该资源包括对治疗暴露的全面注释， 随访和建立的生物储存库，从基因型（SNP阵列）和DNA测序的8，380 幸存者可供研究人员鉴定疾病的遗传易感性-和治疗- 相关的后期影响。目前的补充申请将扩大资源，以提供甲基化 为2,800多名参与者提供分析数据。