Long-term Treatment Related CNS Injury in Survivors of Childhood Cancer
儿童癌症幸存者长期治疗相关的中枢神经系统损伤
基本信息
- 批准号:8065365
- 负责人:
- 金额:$ 17.87万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2010
- 资助国家:美国
- 起止时间:2010-07-01 至 2012-06-30
- 项目状态:已结题
- 来源:
- 关键词:Acute Lymphocytic LeukemiaAdultAftercareAgeAgingAlzheimer&aposs DiseaseArterial Occlusive DiseasesBrainCephalicChildChildhoodChildhood Acute Lymphocytic LeukemiaChronicCognitionCognitiveCognitive deficitsCranial IrradiationCross-Sectional StudiesDataDementiaDevelopmentDiagnosisDiffusion Magnetic Resonance ImagingDoseDrug FormulationsEvaluationExposure toFunctional Magnetic Resonance ImagingFutureGenderGuidelinesHippocampus (Brain)Imaging TechniquesImpaired cognitionInjuryInterventionInvestigationLifeMagnetic Resonance ImagingMalignant Childhood NeoplasmMalignant NeoplasmsMedicalMemoryMemory LossMemory impairmentNervous system structureNeuraxisNeurocognitiveNeurocognitive DeficitOutcomeOutcomes ResearchParietalParietal LobePatternPopulationPrevalenceProtocols documentationQuality of lifeRadiationRadiation therapyRecruitment ActivityReportingResearchRiskSaint Jude Children&aposs Research HospitalScreening procedureSocial FunctioningStenoStrokeStructureSurvivorsTestingTimeVascular Diseasescancer therapycentral nervous system injurychemotherapychildhood cancer survivorclinical carecognitive functioncohortearly childhoodfollow-upfrontal lobelong term memorymemory recallneuroimagingpreventpublic health relevancetreatment durationwhite matter
项目摘要
DESCRIPTION (provided by applicant): Children who received cranial radiation for treatment of childhood cancer are at significant risk for long- term central nervous system (CNS) injury. Our preliminary data suggests long-term memory (delayed recall) is significantly impacted in these adult survivors similar to patterns seen in aging adults with Alzheimer's disease, raising concern that this population may be at risk for early dementia. Furthermore, it is established that cognitive deficits increase with time after exposure to CNS radiation, however, to date, most evaluations of this population have occurred in the first 10 years from exposure. It is unknown whether cognitive status (full scale IQ) worsens beyond this immediate post-treatment period. Ongoing cognitive decline into adulthood would increase risk for many other poor long-term outcomes. The underlying mechanisms of treatment-induced CNS injury and its relationship to long-term cognition are poorly understood. We propose a study to 1) determine the prevalence of long-term memory deficits among 535 adult survivors of childhood ALL treated with cranial radiotherapy and now 15-45 years (mean 30 years) from diagnosis and 2) identify change in cognitive function since the time of the last post-therapy examination (mean 6.9 year from diagnosis) among 145 adult survivors of childhood ALL treated with cranial radiotherapy and now 11-37 years (mean 26 years) from previous examination. In addition, we will use advanced, non-invasive, magnetic resonance imaging techniques to explore associations between long-term memory deficits and 1) alterations in CNS structure and function using advanced MRI volumetric analysis, diffusion tensor imaging and functional MRI and 2) cerbrovasculopathy (including stroke) of both large and small vessels in a randomly selected subset of 140 survivors providing sufficient statistical power to identify associations between structure, function and memory outcomes. The results of this study will guide future screening practices for both neurocognitive deficits and cerbrovasculopathy in adult survivors. If long-term memory deficits are confirmed in this study, future longitudinal investigation will be necessary to determine long-term risk for dementia as well as intervention strategies to prevent or delay dementia. Access to more than 4,000 adult survivors of childhood cancer treated at St. Jude Children's Research Hospital makes this study feasible.
PUBLIC HEALTH RELEVANCE: Identifying long-term memory loss and evidence for worsening cognitive status will benefit survivors and those who treat survivors of childhood cancer. Results from this proposed cross-sectional study of radiation exposed adult survivors of childhood cancer will directly inform 1) future outcomes research, 2) formulation of clinical care guidelines, including screening practices 3) development and testing of intervention strategies.
描述(申请人提供):接受颅脑放射治疗儿童癌症的儿童有长期中枢神经系统(CNS)损伤的巨大风险。我们的初步数据表明,这些成年幸存者的长期记忆(延迟回忆)受到显著影响,类似于阿尔茨海默病老年患者的模式,这引发了人们对这一人群可能面临早期痴呆症风险的担忧。此外,已经证实,暴露于中枢神经系统辐射后,认知缺陷会随着时间的推移而增加,然而,到目前为止,对这一人群的大多数评估都发生在暴露后的前10年。目前尚不清楚认知状态(满分智商)是否会在治疗后立即恶化。持续到成年的认知衰退会增加许多其他不良长期结果的风险。治疗引起的中枢神经系统损伤的潜在机制及其与长期认知的关系尚不清楚。我们建议进行一项研究:1)确定所有接受颅脑放疗的儿童成年幸存者中长期记忆缺陷的发生率,现在是15-45岁(平均30岁);2)确定145名接受颅脑放疗的成年幸存者自最后一次治疗后检查(自确诊起平均6.9年)以来的认知功能变化。此外,我们将使用先进的非侵入性磁共振成像技术来探索长期记忆缺陷与1)使用先进的MRI体积分析、弥散张量成像和功能MRI的中枢神经系统结构和功能的变化以及2)随机选择的140名幸存者的大血管和小血管的脑血管病变(包括中风)之间的联系,提供足够的统计能力来确定结构、功能和记忆结果之间的联系。这项研究的结果将指导未来对成年幸存者的神经认知缺陷和脑血管病变的筛查实践。如果长期记忆缺陷在这项研究中得到证实,未来的纵向调查将有必要确定痴呆症的长期风险以及预防或延缓痴呆症的干预策略。接触到在圣犹大儿童研究医院接受治疗的4000多名成年儿童癌症幸存者,使这项研究具有可行性。
公共卫生相关性:确定长期记忆丧失和认知状况恶化的证据将使幸存者和那些治疗儿童癌症幸存者的人受益。这项拟议的儿童癌症成年幸存者辐射暴露横断面研究的结果将直接为1)未来结果研究、2)临床护理指南的制定,包括筛查实践3)干预策略的开发和测试提供信息。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Gregory Armstrong其他文献
Gregory Armstrong的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Gregory Armstrong', 18)}}的其他基金
ExtractEHR Pilot Childhood Cancer Data Initiative (CCDI)
ExtractEHR 儿童癌症数据试点计划 (CCDI)
- 批准号:
10852234 - 财政年份:2023
- 资助金额:
$ 17.87万 - 项目类别:
Sen-Survivors: An open-label intervention trial for frailty and senescence
Sen-Survivors:针对虚弱和衰老的开放标签干预试验
- 批准号:
9890475 - 财政年份:2020
- 资助金额:
$ 17.87万 - 项目类别:
Longitudinal Cardiotoxicity in Adult Survivors Childhood Cancer
成年幸存者儿童癌症的纵向心脏毒性
- 批准号:
8777088 - 财政年份:2012
- 资助金额:
$ 17.87万 - 项目类别:
Longitudinal Cardiotoxicity in Adult Survivors Childhood Cancer
成年幸存者儿童癌症的纵向心脏毒性
- 批准号:
8237845 - 财政年份:2012
- 资助金额:
$ 17.87万 - 项目类别:
Longitudinal Cardiotoxicity in Adult Survivors Childhood Cancer
成年幸存者儿童癌症的纵向心脏毒性
- 批准号:
8434145 - 财政年份:2012
- 资助金额:
$ 17.87万 - 项目类别:
Longitudinal Cardiotoxicity in Adult Survivors Childhood Cancer
成年幸存者儿童癌症的纵向心脏毒性
- 批准号:
8979675 - 财政年份:2012
- 资助金额:
$ 17.87万 - 项目类别:
Long-term Treatment Related CNS Injury in Survivors of Childhood Cancer
儿童癌症幸存者长期治疗相关的中枢神经系统损伤
- 批准号:
7991251 - 财政年份:2010
- 资助金额:
$ 17.87万 - 项目类别:
相似海外基金
Co-designing a lifestyle, stop-vaping intervention for ex-smoking, adult vapers (CLOVER study)
为戒烟的成年电子烟使用者共同设计生活方式、戒烟干预措施(CLOVER 研究)
- 批准号:
MR/Z503605/1 - 财政年份:2024
- 资助金额:
$ 17.87万 - 项目类别:
Research Grant
Early Life Antecedents Predicting Adult Daily Affective Reactivity to Stress
早期生活经历预测成人对压力的日常情感反应
- 批准号:
2336167 - 财政年份:2024
- 资助金额:
$ 17.87万 - 项目类别:
Standard Grant
RAPID: Affective Mechanisms of Adjustment in Diverse Emerging Adult Student Communities Before, During, and Beyond the COVID-19 Pandemic
RAPID:COVID-19 大流行之前、期间和之后不同新兴成人学生社区的情感调整机制
- 批准号:
2402691 - 财政年份:2024
- 资助金额:
$ 17.87万 - 项目类别:
Standard Grant
Elucidation of Adult Newt Cells Regulating the ZRS enhancer during Limb Regeneration
阐明成体蝾螈细胞在肢体再生过程中调节 ZRS 增强子
- 批准号:
24K12150 - 财政年份:2024
- 资助金额:
$ 17.87万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Migrant Youth and the Sociolegal Construction of Child and Adult Categories
流动青年与儿童和成人类别的社会法律建构
- 批准号:
2341428 - 财政年份:2024
- 资助金额:
$ 17.87万 - 项目类别:
Standard Grant
Understanding how platelets mediate new neuron formation in the adult brain
了解血小板如何介导成人大脑中新神经元的形成
- 批准号:
DE240100561 - 财政年份:2024
- 资助金额:
$ 17.87万 - 项目类别:
Discovery Early Career Researcher Award
Laboratory testing and development of a new adult ankle splint
新型成人踝关节夹板的实验室测试和开发
- 批准号:
10065645 - 财政年份:2023
- 资助金额:
$ 17.87万 - 项目类别:
Collaborative R&D
Usefulness of a question prompt sheet for onco-fertility in adolescent and young adult patients under 25 years old.
问题提示表对于 25 岁以下青少年和年轻成年患者的肿瘤生育力的有用性。
- 批准号:
23K09542 - 财政年份:2023
- 资助金额:
$ 17.87万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Identification of new specific molecules associated with right ventricular dysfunction in adult patients with congenital heart disease
鉴定与成年先天性心脏病患者右心室功能障碍相关的新特异性分子
- 批准号:
23K07552 - 财政年份:2023
- 资助金额:
$ 17.87万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Issue identifications and model developments in transitional care for patients with adult congenital heart disease.
成人先天性心脏病患者过渡护理的问题识别和模型开发。
- 批准号:
23K07559 - 财政年份:2023
- 资助金额:
$ 17.87万 - 项目类别:
Grant-in-Aid for Scientific Research (C)