Cancer Control and Survivorship Program
癌症控制和生存计划
基本信息
- 批准号:10378575
- 负责人:
- 金额:$ 7.02万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1997
- 资助国家:美国
- 起止时间:1997-04-01 至 2024-02-29
- 项目状态:已结题
- 来源:
- 关键词:AddressAreaBehavioralBiometryCancer CenterCancer Center Support GrantCancer ControlCancer SurvivorshipCardiopulmonaryChildhoodChildhood Cancer Survivor StudyChildhood Cancer TreatmentChronic DiseaseClinical ResearchClinical ServicesCognitive deficitsCohort StudiesCollaborationsComprehensive Cancer CenterConsensusDataDepartment chairDisciplineDivision of Cancer Epidemiology and GeneticsEducationEmploymentEndocrineEnrollmentEpidemiologyFatigueFundingFutureGeneticGenetic ResearchGoalsGrantGuidelinesHealthHealth behaviorIncidenceIndividualInfrastructureInstitutionInternationalInterventionKnowledgeLate EffectsLeadLeadershipLife ExpectancyLong-Term SurvivorsMalignant Childhood NeoplasmMedicineMelissaModelingMorbidity - disease rateNCI-Designated Cancer CenterNatureNeoplasmsNeurosciencesObservational StudyOncologyOutcomeOutcomes ResearchPediatric Oncology GroupPeer ReviewPopulationPostdoctoral FellowPremature MortalityPrevalencePsychologyPublicationsQuality of lifeRandomized Clinical TrialsResearchResearch InfrastructureResearch PersonnelResource SharingResourcesRiskRisk FactorsRoleSaint Jude Children&aposs Research HospitalScheduleSeminalStructureSurvival RateSurvivorsTherapeuticTrainingTranslatingTranslationsTreatment Side Effectsadverse outcomebasecancer epidemiologycancer preventioncareerchildhood cancer survivorclinical practicecohortdesignefficacy evaluationexperiencehigh riskhigh risk populationimprovedinnovationinsightinter-institutionalinternational centermembermultidisciplinarynext generation sequencingpreservationprogramspsychosocialrecruitreproductivescreeningsurvivorshiptreatment strategyworking group
项目摘要
PROJECT SUMMARY/ABSTRACT—Cancer Control and Survivorship Program
The overarching goal of the Cancer Control and Survivorship Program (CCSP) is to conduct highly innovative
clinical, genetic, and observational research, and translate our findings into effective strategies to avert or
mitigate treatment-related complications and improve the quality of life of childhood cancer survivors. Drs. Leslie
L. Robison, chair of the Department of Epidemiology and Cancer Control, and Melissa Hudson, director of the
Division of Cancer Survivorship, lead the Program. Their leadership roles in the CCSP's two NCI-funded cohorts,
St. Jude Lifetime Cohort Study (SJLIFE) and the Childhood Cancer Survivor Study (CCSS), have facilitated
seminal discoveries characterizing the magnitude and scope of morbidity of the childhood cancer experience,
including the resulting burden of chronic disease and subsequent neoplasms and their contribution to premature
mortality. Knowledge gained from this research has influenced the design of contemporary pediatric cancer
treatment strategies and provided critical data to guide health surveillance and health preserving interventions
for long-term survivors. The CCSP is structured around an extensive shared research infrastructure designed to
support and enhance the research conducted by Program members. This infrastructure reflects a combination
of departmental-focused resources, augmented by institutional and SJCCC-specific resources plus clinical
services external to the institution. The CCSP has a total of 16 members (11 Full and 5 Associate), representing
the Departments of Epidemiology & Cancer Control, Oncology, Psychology, Global Pediatric Medicine, and
Pediatric Medicine. The design and conduct of innovative research is facilitated by 7 discipline-specific CCSP
working groups: Neurosciences, Cardiopulmonary, Endocrine-Reproductive, Genetics, Global Outcomes,
Psychosocial-Behavioral, and Epidemiology-Biostatistics, who meet on a regular schedule (bi-weekly or
monthly). During the current grant period (2013-2017), CCSP members have actively engaged in intra- and inter-
programmatic research collaborations. Research publications by CCSP members totaled 424 and demonstrate
the highly collaborative nature of the Program with 50% reflecting an intra-programmatic and 25.9% inter-
programmatic collaboration. During the current funding period, CCSP members initiated/conducted trials
addressing approaches to enhance health screening for at-risk survivors, promote positive health behaviors,
remediate treatment-induced cognitive deficits, and reduce fatigue, contributing a total of 2283 enrollments to
interventional non-therapeutic trials. Many of these trials reflect a direct translation of observational research
conducted by CCSP members. CCSP members have participated in a wide variety of multi-group collaborations
(involving more than 20 NCI-designated Cancer Centers, the NCI Division of Cancer Epidemiology and Genetics,
the Children's Oncology Group, and multiple international centers) to characterize treatment and genetic factors
conferring high risk for specific late effects. CCSP members have a total of $4.2M in annual peer-reviewed
funding, including $4.1M in NCI funding.
项目概要/摘要-癌症控制和生存计划
癌症控制和生存计划(CCSP)的总体目标是进行高度创新
临床,遗传和观察研究,并将我们的发现转化为有效的策略,以避免或
减轻治疗相关并发症,改善儿童癌症幸存者的生活质量。莱斯利博士
L.流行病学和癌症控制系主任罗宾逊和癌症中心主任梅丽莎哈德逊说,
癌症幸存者部门,领导该计划。他们在CCSP的两个NCI资助的队列中的领导角色,
圣Jude Lifetime队列研究(SJLIFE)和儿童癌症幸存者研究(CCSS)
开创性的发现表征了儿童癌症经历的发病率的程度和范围,
包括由此造成的慢性疾病和随后的肿瘤负担及其对过早死亡的影响,
mortality.从这项研究中获得的知识影响了当代儿科癌症的设计
治疗策略,并提供关键数据,以指导健康监测和健康保护干预措施
长期生存者。CCSP围绕广泛的共享研究基础设施构建,旨在
支持和加强项目成员进行的研究。这种基础设施反映了一种组合
以部门为重点的资源,由机构和SJCCC特定资源以及临床
机构外的服务。CCSP共有16名成员(11名正式成员和5名准成员),
流行病学和癌症控制,肿瘤学,心理学,全球儿科医学,和
儿科医学创新研究的设计和实施由7个特定学科的CCSP促进
工作组:神经科学、心脏病学、内分泌-生殖、遗传学、全球成果、
社会心理学-行为学和流行病学-生物统计学,他们定期开会(每两周或
每月)。在当前的赠款期间(2013-2017年),CCSP成员积极参与内部和内部,
研究合作项目。CCSP成员的研究出版物共计424篇,
该计划的高度合作性质,50%反映了计划内的合作,25.9%反映了计划间的合作,
方案合作。在当前的资助期间,CCSP成员发起/进行了试验
探讨加强对高危幸存者的健康检查,促进积极的健康行为,
修复治疗引起的认知缺陷,并减轻疲劳,共招募2283例患者,
干预性非治疗性试验。这些试验中有许多反映了观察性研究的直接翻译
由CCSP成员执行。CCSP成员参加了各种各样的多组合作
(涉及20多个国家癌症研究所指定的癌症中心,国家癌症研究所癌症流行病学和遗传学部门,
儿童肿瘤组和多个国际中心),以表征治疗和遗传因素
从而赋予特定迟发效应的高风险。CCSP成员每年共获得420万美元的同行评审
资金,包括410万美元的NCI资金。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Gregory Armstrong其他文献
Gregory Armstrong的其他文献
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{{ truncateString('Gregory Armstrong', 18)}}的其他基金
ExtractEHR Pilot Childhood Cancer Data Initiative (CCDI)
ExtractEHR 儿童癌症数据试点计划 (CCDI)
- 批准号:
10852234 - 财政年份:2023
- 资助金额:
$ 7.02万 - 项目类别:
Sen-Survivors: An open-label intervention trial for frailty and senescence
Sen-Survivors:针对虚弱和衰老的开放标签干预试验
- 批准号:
9890475 - 财政年份:2020
- 资助金额:
$ 7.02万 - 项目类别:
Longitudinal Cardiotoxicity in Adult Survivors Childhood Cancer
成年幸存者儿童癌症的纵向心脏毒性
- 批准号:
8777088 - 财政年份:2012
- 资助金额:
$ 7.02万 - 项目类别:
Longitudinal Cardiotoxicity in Adult Survivors Childhood Cancer
成年幸存者儿童癌症的纵向心脏毒性
- 批准号:
8237845 - 财政年份:2012
- 资助金额:
$ 7.02万 - 项目类别:
Longitudinal Cardiotoxicity in Adult Survivors Childhood Cancer
成年幸存者儿童癌症的纵向心脏毒性
- 批准号:
8434145 - 财政年份:2012
- 资助金额:
$ 7.02万 - 项目类别:
Longitudinal Cardiotoxicity in Adult Survivors Childhood Cancer
成年幸存者儿童癌症的纵向心脏毒性
- 批准号:
8979675 - 财政年份:2012
- 资助金额:
$ 7.02万 - 项目类别:
Long-term Treatment Related CNS Injury in Survivors of Childhood Cancer
儿童癌症幸存者长期治疗相关的中枢神经系统损伤
- 批准号:
8065365 - 财政年份:2010
- 资助金额:
$ 7.02万 - 项目类别:
Long-term Treatment Related CNS Injury in Survivors of Childhood Cancer
儿童癌症幸存者长期治疗相关的中枢神经系统损伤
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7991251 - 财政年份:2010
- 资助金额:
$ 7.02万 - 项目类别:
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