CCSS Expansion Study Supplement

CCSS 扩展研究补充材料

基本信息

批准号：
10876211
负责人：
Gregory Armstrong
金额：
$ 96.3万
依托单位：
ST. JUDE CHILDREN'S RESEARCH HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-07-01 至 2026-11-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10876211
关键词：
Address Adolescent Child Childhood Childhood Cancer Survivor Study Cohort Studies Collection DNA sequencing Data Data Collection Diagnosis Digital Imaging and Communications in Medicine Disease susceptibility Eligibility Determination Future Genetic Predisposition to Disease Genotype Health Infrastructure Institution Intervention Investigation Late Effects Malignant Childhood Neoplasm Malignant Neoplasms Methodology Methods Modernization Morbidity - disease rate Outcome Paper Participant Pilot Projects Process Publications Quality of life Radiation therapy Radiometry Records Research Research Personnel Resources Risk SNP array Source Survival Rate Survivors Testing biobank childhood cancer survivor cohort computerized data processing data standards follow-up health related quality of life high risk population improved mortality multidisciplinary recruit screening guidelines survivorship

项目摘要

ABSTRACT The Childhood Cancer Survivor Study (CCSS) is a multi-institutional, multi-disciplinary collaborative research resource established to systematically evaluate long-term outcomes among children diagnosed with cancer who survived five or more years from diagnosis. With the successful recruitment and longitudinal follow-up of the cohort that includes survivors diagnosed and treated over three decades (1970-1999), the CCSS is the world’s largest established open resource for survivorship research with 38,036 eligible survivors available for investigation of late mortality, and 25,665 participants who have contributed health-related and quality of life outcomes. The resource includes comprehensive annotation of treatment exposures, ongoing longitudinal follow-up and an established biorepository from which genotype (SNP array) and DNA sequencing of 8,380 survivors are available to investigators for identification of genetic susceptibility for disease- and treatment- related late effects. Radiation therapy (RT) has substantially evolved over the past two decades since the establishment of the CCSS cohort. As opposed to previous CCSS methods which required paper copies of RT planning documents for review by the CCSS Radiation Dosimetry Center at MD Anderson, data from modern RT planning, collection and processing multi-institutional RT DICOM data spanning two decades will require a new and robust infrastructure. In this pilot study, we propose to collect and process 100 radiotherapy records from each of five representative CCSS institutions with the aim of a developing and testing a standardized data collection and processing methodology for use in a future CCSS expansion.

抽象的儿童癌症幸存者研究（CCSS）是一项多机构的多学科合作研究建立的资源是为了系统地评估被诊断为癌症的儿童的长期结局的资源从诊断术中幸存了五年或更长时间。随着成功的招募和纵向随访 CCSS是世界上的三十年（1970- 1999年），包括经过诊断和治疗的生存的队列最大的既定开放资源用于生存研究，有38,036个合格的表面对晚期死亡率的调查，以及有25,665名参与者，他们贡献了与健康有关的生活质量结果。资源包括全面的治疗暴露注释，正在进行的纵向后续和已建立的生物座，基因型（SNP阵列）和8,380的DNA测序研究人员可以使用幸存者来鉴定疾病和治疗的遗传易感性相关的后期效果。放射疗法（RT）在过去的二十年中已经大幅发展建立CCSS队列。与以前需要RT纸副本的CCSS方法相反 MD Anderson的CCSS辐射剂量学中心进行审查的计划文档，现代数据 RT规划，收集和处理多机构的RT DICOM数据跨越了二十年新的和强大的基础架构。在这项试点研究中，我们建议收集和处理100个放射疗法记录从五个代表性CCSS机构中的每一个中，以开发和测试标准化数据收集和处理方法用于将来的CCSS扩展。