Mechanism of signal transduction and receptor activation in ligand gated ion channel receptors

配体门控离子通道受体的信号转导和受体激活机制

• 批准号: nhmrc : 230806
• 负责人: Prof Peter Schofield
• 金额: $ 30.41万
• 依托单位: Garvan Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2003
• 资助国家: 澳大利亚
• 起止时间: 2003-01-01 至 2005-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/mechanism-signal-transduction-channel-receptors/77769
• 关键词: Mechanism; signal; transduction; receptor; activation

This project seeks to provide fundamental new information about the means by which neurotransmitter receptors, which mediate fast synaptic neurotransmission, operate. It will use a range of molecular advances made by this and other laboratories to clarify how neurotransmitters enable their receptors to activate and signal. This fundamental information is of major medical significance as defective synaptic transmission, caused by mutations in ligand gated ion channel receptors, give rise to a number of neurological and psychiatric disease states. The ligand gated receptors are also major targets for therapeutic drugs and the information gained in this study may also provide insights into new ways in which drugs could be used to enhance or inhibit synaptic signalling.

该项目旨在提供有关神经递质受体（介导快速突触神经传递）运作方式的基本新信息。它将利用这个实验室和其他实验室取得的一系列分子进展来阐明神经递质如何使它们的受体激活和发出信号。这一基本信息具有重要的医学意义，因为由配体门控离子通道受体突变引起的突触传递缺陷会导致许多神经和精神疾病状态。配体门控受体也是治疗药物的主要靶点，本研究中获得的信息也可能为药物用于增强或抑制突触信号传导的新方法提供见解。