Molecular determinants of inhibitory synaptic function studied using mutant and transgenic mice

使用突变体和转基因小鼠研究抑制性突触功能的分子决定因素

• 批准号: nhmrc : 276403
• 负责人: Prof Peter Schofield
• 金额: $ 33.11万
• 依托单位: Garvan Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2004
• 资助国家: 澳大利亚
• 起止时间: 2004-01-01 至 2006-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/molecular-determinants-inhibitory-transgenic-mice/82038
• 关键词: Molecular; determinants; inhibitory; synaptic; function

Communication between nerve cells is the key to effective brain function and when disturbed, pathological states such as epilepsy, schizophrenia, fear and anxiety, spasticity and motor disorders ensue. This project is based on new data which suggests that the site of this communication, called the synapse, is a much more dynamic structure than previously thought. Based on our work to date, where we have demonstrated the recruitment of selected classes of neurotransmitter receptors into synapses, our aim is to use a range of naturally occuring mice mutants, as well as transgenic mice to modulate the receptor levels and so to examine the role of synaptic function and synaptic dynamics. The outcomes of this project will provide fundamental new knnowledge aimed at understanding how communication in the nervous system works and may suggest ways in which modulation of this information flow could be used to treat disorders of brain function.

神经细胞之间的交流是有效大脑功能的关键，当受到干扰时，癫痫、精神分裂症、恐惧和焦虑、痉挛和运动障碍等病理状态就会随之而来。这个项目是基于新的数据，这些数据表明，这种交流的地点，称为突触，是一个比以前认为的更动态的结构。根据我们迄今为止的工作，我们已经证明了将选定的神经递质受体招募到突触中，我们的目标是使用一系列自然发生的小鼠突变体以及转基因小鼠来调节受体水平，从而检查突触功能和突触动力学的作用。这个项目的结果将为理解神经系统中的交流是如何工作的提供基本的新知识，并可能提出通过这种信息流的调节来治疗脑功能紊乱的方法。