Longitudinal Investigation of TMS as a Tool to Improve Alcohol Treatment Outcomes
TMS 作为改善酒精治疗结果工具的纵向调查
基本信息
- 批准号:10844805
- 负责人:
- 金额:$ 4.17万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-09-20 至 2024-08-31
- 项目状态:已结题
- 来源:
- 关键词:Administrative SupplementApplications GrantsBrainBudgetsDataDouble-Blind MethodFunctional Magnetic Resonance ImagingFundingGoalsHeavy DrinkingInterdisciplinary StudyInvestigationLeftMeasuresMedialNational Institute on Alcohol Abuse and AlcoholismOutcome MeasureOutcome StudyParticipantPrefrontal CortexProcessRandomizedTreatment ProtocolsTreatment outcomeUniversitiesalcohol abuse therapyalcohol cuealcohol responsebrain basedcostcost estimatecravingdata archivedata sharingdata submissionevidence baseexperienceforestimprovedmedical schoolsprimary outcomerandomized placebo controlled studysecondary outcometooltreatment strategy
项目摘要
Project Summary
The primary purpose of this administrative supplement to AA027705 is to cover the costs associated with data
sharing as required by the NIAAA. The multi-PIs of this project took over in November of 2022 when the
original project PI left Wake Forest University School of Medicine. As part of this project transfer, it became
clear that study data was not actively being submitted to the National Institute on Alcohol Abuse and
Alcoholism Data Archive (NIAAADA). Unfortunately, when the original grant proposal was submitted, funds
were not requested to cover the costs associated with data submission. Based on all the information we have
gathered about the submission process, our experience with the data from this project, the fact that none of our
data fields are in the NDA format, and estimates from NDA Data Submission Cost Estimation Tool, we have
determined the costs that will be incurred. There are no changes in the study aims as part of this administrative
supplement. The project remains a double-blind placebo controlled, randomized study to evaluate the relative
efficacy of 2 potential TBS treatment strategies for AUD. Specifically, participants will be randomized to receive
real or sham TBS delivered to the ventral medial prefrontal cortex (vmPFC), or dorsolateral prefrontal cortex
(dlPFC). The primary outcome measures remain the percent days abstinent and the percentage of heavy
drinking days. Secondary outcomes measures include changes in craving and change in brain response to
alcohol cues will be measured using functional magnetic resonance imaging. The requested budget will cover
the cost of submission of all the data relevant to the primary and secondary outcomes of the study from the
planned 160 study participants.
项目摘要
本AA027705管理补充文件的主要目的是支付与数据相关的费用
根据NIAAA的要求进行共享。该项目的多个PI于2022年11月接管,
最初的项目PI离开了维克森林大学医学院。作为项目转移的一部分,
很明显,研究数据没有积极提交给国家酒精滥用研究所,
酒精中毒数据档案(NIAAADA)。不幸的是,当最初的赠款提案提交时,
没有要求支付与提交数据有关的费用。根据我们掌握的所有信息
收集了关于提交过程,我们对这个项目的数据的经验,事实上,我们的
数据字段采用NDA格式,NDA数据提交成本估算工具中的估算,我们有
确定了将要发生的费用。作为本行政管理的一部分,研究目的没有变化。
补充.该项目仍然是一项双盲、安慰剂对照、随机化研究,以评估相对于
2种潜在TBS治疗策略对AUD的疗效。具体而言,受试者将随机接受
将真实的或假TBS递送至腹侧内侧前额叶皮质(vmPFC)或背外侧前额叶皮质
(dlPFC)。主要结果指标仍然是禁欲天数百分比和重度
喝酒的日子次要结果测量包括渴望的变化和大脑反应的变化。
酒精暗示将使用功能性磁共振成像来测量。预算将涵盖
提交与研究主要和次要结局相关的所有数据的费用,
计划160名研究参与者。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Merideth A. Addicott其他文献
Nicotine withdrawal induces neural and behavioral deficits in reward processing
尼古丁戒断会导致奖励处理中的神经和行为缺陷
- DOI:
- 发表时间:
2017 - 期刊:
- 影响因子:0
- 作者:
Jason A. Oliver;D. Evans;Merideth A. Addicott;T. Brandon;D. Drobes - 通讯作者:
D. Drobes
The Effects of Dietary Caffeine Use and Abstention on Blood Oxygen Level-Dependent Activation and Cerebral Blood Flow.
膳食咖啡因的使用和戒断对血氧水平依赖性激活和脑血流量的影响。
- DOI:
10.1089/jcr.2011.0027 - 发表时间:
2012 - 期刊:
- 影响因子:0
- 作者:
Merideth A. Addicott;A. Peiffer;P. Laurienti - 通讯作者:
P. Laurienti
Erratum to: Smoking withdrawal is associated with increases in brain activation during decision making and reward anticipation: A preliminary study
- DOI:
10.1007/s00213-011-2531-x - 发表时间:
2011-10-18 - 期刊:
- 影响因子:3.300
- 作者:
Merideth A. Addicott;David A. A. Baranger;Rachel V. Kozink;Moria J. Smoski;Gabriel S. Dichter;F. Joseph McClernon - 通讯作者:
F. Joseph McClernon
Merideth A. Addicott的其他文献
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{{ truncateString('Merideth A. Addicott', 18)}}的其他基金
Reducing distress and tobacco smoking in cancer survivors: a TDCS telehealth study
减少癌症幸存者的痛苦和吸烟:TDCS 远程医疗研究
- 批准号:
10680370 - 财政年份:2022
- 资助金额:
$ 4.17万 - 项目类别:
Effects of ketamine on tobacco use disorder - Resubmission
氯胺酮对烟草使用障碍的影响 - 重新提交
- 批准号:
10371688 - 财政年份:2022
- 资助金额:
$ 4.17万 - 项目类别:
Reducing distress and tobacco smoking in cancer survivors: a TDCS telehealth study
减少癌症幸存者的痛苦和吸烟:TDCS 远程医疗研究
- 批准号:
10390202 - 财政年份:2022
- 资助金额:
$ 4.17万 - 项目类别:
Effects of ketamine on tobacco use disorder - Resubmission
氯胺酮对烟草使用障碍的影响 - 重新提交
- 批准号:
10625289 - 财政年份:2022
- 资助金额:
$ 4.17万 - 项目类别:
Neural correlates of distress tolerance in tobacco addiction
烟草成瘾中痛苦耐受性的神经相关性
- 批准号:
10496770 - 财政年份:2021
- 资助金额:
$ 4.17万 - 项目类别:
Translational approaches to TMS treatment development for smoking
吸烟 TMS 治疗开发的转化方法
- 批准号:
10152574 - 财政年份:2019
- 资助金额:
$ 4.17万 - 项目类别: