Acute and Chronic Nicotine Modulation of Reinforcement Learning

强化学习的急性和慢性尼古丁调节

• 批准号: 9575325
• 负责人: Merideth A. Addicott
• 金额: $ 11.66万
• 依托单位: UNIV OF ARKANSAS FOR MED SCIS
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-11-01 至 2019-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9575325
• 关键词: Abstinence; Acute; Affect; Alcohols; Americas; Area; Award; Behavior; Cause of Death; Cessation of life; Chronic; Clinical; Cocaine; Collaborations; Complement; Cues; Data; Decision Making; Dependence; Disease; Dopamine; Drug Addiction; Drug usage; Ensure; Environment; Etiology; Expectancy; Exposure to; Face; Faculty; Foundations; Functional Magnetic Resonance Imaging; Future; Goals; Grant; Heroin; Hour; Human; Incentives; Institution; Investigation; Knowledge; Learning; Literature; Magnetic Resonance Imaging; Maintenance; Mentors; Methodology; Modeling; Motivation; Nicotine; Nicotine Dependence; Nucleus Accumbens; Outcome; Pathway interactions; Pharmaceutical Preparations; Placebos; Play; Prefrontal Cortex; Principal Investigator; Process; Psychological reinforcement; Psychopharmacology; Reaction Time; Relapse; Research; Research Personnel; Research Training; Rewards; Role; Satiation; Scanning; Shapes; Signal Transduction; Smoker; Smoking; Smoking Behavior; Stimulus; Techniques; Tobacco; Tobacco Dependence; Tobacco use; Training; Training and Education; Uncertainty; United States; Universities; addiction; behavior prediction; cigarette smoking; design; disability; drug abuse vulnerability; drug of abuse; experience; functional MRI scan; interest; neuroeconomics; neuroimaging; nicotine craving; non-drug; non-smoker; novel strategies; public health relevance; putamen; reinforcer; relating to nervous system; reward processing; skills

DESCRIPTION (provided by applicant): The purpose of this study is to investigate the modulatory effects of acute and chronic nicotine exposure on reinforcement learning for monetary rewards. Nicotine, the primary addictive component in tobacco, is a weak reinforcer that does not induce robust euphoric effects like other drugs of abuse (e.g., cocaine, alcohol), yet produces a higher rate of dependence among tobacco users than among users of other addictive drugs. A potential explanation of this paradox is that nicotine amplifies the salience of other stimuli that have some incentive value and prolonged exposure could result in dysregulated reward processing. Reinforcement learning is the process of learning what actions to take to maximize reward, and may be the mechanism by which nicotine amplifies the incentive value of other stimuli. A key component of reinforcement learning is the prediction error, which is the difference between the actual and the expected reward outcome. Neuroimaging studies have shown that BOLD activation in the mesocorticolimbic pathway correlates with prediction errors during reinforcement learning paradigms. The overarching aim of this proposal is to use neuroeconomic models of reinforcement learning to study the acute and chronic effects of nicotine on motivational behavior and prediction error-related neural activation using a task with probabilistic outcomes and fMRI. Nonsmokers will be scanned following acute nicotine and placebo administration, and smokers will be scanned following normal smoking behavior and 24-hours of smoking abstinence. This proposal will bridge the gap in the literature between neuroeconomic and addiction research and these results will inform whether the initiation and maintenance of smoking behavior could be facilitated by the effects of nicotine on reinforcement learning. The Principal Investigator (PI) will be mentored and advised by a team of faculty with expertise in nicotine psychopharmacology, fMRI, and neuroeconomics. The institution provides exceptional facilities and departments dedicated to these three fields of research. In addition to learning how to design and conduct clinical nicotine research, this training plan with provide the PI with the opportunity to integrate several distinct, yet overlapping, fields of research in order to explore new approaches to understanding the etiology of nicotine addiction. This proposal builds upon the PI's previous pharmaco-MRI experience, and will allow her to develop new skills while contributing to research on the effects of nicotine on decision-making behavior in humans. The education, training, and research goals described in this proposal will provide the applicant with the research experience necessary to become a successful independent investigator.

描述（由申请人提供）：本研究的目的是探讨急性和慢性尼古丁暴露对金钱奖励强化学习的调节作用。尼古丁是烟草中的主要成瘾性成分，是一种弱强化剂，不会像其他滥用药物（如可卡因、酒精）那样引起强烈的欣快效果，但在烟草使用者中产生的依赖率高于其他成瘾性药物的使用者。对这一矛盾现象的一种可能解释是，尼古丁放大了

项目成果

Caffeine Use Disorder: A Review of the Evidence and Future Implications.

咖啡因使用障碍：证据回顾和未来影响。

• DOI: 10.1007/s40429-014-0024-9
• 发表时间: 2014
• 期刊: Current addiction reports
• 影响因子: 4.3
• 作者: Addicott,MeridethA

Effort-based decision making varies by smoking status.

基于努力的决策因吸烟状况而异。

• DOI: 10.1007/s00213-019-05437-3
• 发表时间: 2020
• 期刊: Psychopharmacology
• 影响因子: 3.4
• 作者: Addicott,MeridethA;Wardle,MargaretC;Selig,JamesP
• 通讯作者: Selig,JamesP

Distress tolerance to auditory feedback and functional connectivity with the auditory cortex.

• DOI: 10.1016/j.pscychresns.2018.10.003
• 发表时间: 2018-12-30
• 期刊: Psychiatry research. Neuroimaging
• 作者: Addicott MA;Daughters SB;Strauman TJ;Appelbaum LG
• 通讯作者: Appelbaum LG