Effects of ketamine on tobacco use disorder - Resubmission

氯胺酮对烟草使用障碍的影响 - 重新提交

基本信息

项目摘要

ABSTRACT Arkansas ranks third in the nation for cigarette smoking prevalence (25% of the population) and ranks second for smoking-attributed cancer mortality (33.5% mortality). More effective interventions for tobacco addiction are needed, and there is an ongoing need for non-nicotine based interventions in particular. For example, nicotine itself may potentially increase the risk of post-surgical complications. The reinforcing effects of nicotine may be due to its effects on glutamatergic transmission, and the use of glutamatergic medications for tobacco addiction has been proposed. A glutamate N-methyl-D-aspartate (NMDA) receptor antagonist, ketamine, has shown preclinical efficacy in reducing nicotine self-administration, similar to other NMDA antagonists. Furthermore, ketamine has shown promise in reducing craving, withdrawal symptoms, and use of other addictive drugs in humans. However, ketamine’s effects on tobacco use disorder are not yet known and an investigation of its impact on the neuropsychological substrates of tobacco addiction is warranted. While the effects of ketamine on tobacco addiction have not been tested in humans, there is indirect evidence of its potential efficacy to reduce tobacco use. To fill this gap in knowledge, we have begun collecting preliminary data supporting the feasibility and tolerability of ketamine in smokers who complete lab measures of cigarette craving and smoking latency before, and 24 hours after, an infusion of ketamine or placebo. To advance this line of research, we propose a within-subject, cross-over trial of smokers who will receive an infusion of ketamine and an active control drug in counter-balanced order, at least 2 weeks apart. In Aim 1, we will measure changes in craving, tobacco withdrawal, and tobacco use behavior. In Aim 2, we will determine the effects of ketamine on brain function using functional magnetic resonance imaging. The safety, tolerability, and acceptability of ketamine will be assessed using physiological, drug effect, and side-effect measures. This proposal is significant because it will be the first to translate preclinical research on a novel pharmacotherapy for tobacco addiction. This information is valuable because knowing precisely how ketamine disrupts tobacco addiction will help guide future therapeutic use of ketamine or the development of other pharmacotherapies with similar mechanisms of action.
摘要

项目成果

期刊论文数量(0)
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科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Merideth A. Addicott其他文献

Nicotine withdrawal induces neural and behavioral deficits in reward processing
尼古丁戒断会导致奖励处理中的神经和行为缺陷
  • DOI:
  • 发表时间:
    2017
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Jason A. Oliver;D. Evans;Merideth A. Addicott;T. Brandon;D. Drobes
  • 通讯作者:
    D. Drobes
The Effects of Dietary Caffeine Use and Abstention on Blood Oxygen Level-Dependent Activation and Cerebral Blood Flow.
膳食咖啡因的使用和戒断对血氧水平依赖性激活和脑血流量的影响。
  • DOI:
    10.1089/jcr.2011.0027
  • 发表时间:
    2012
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Merideth A. Addicott;A. Peiffer;P. Laurienti
  • 通讯作者:
    P. Laurienti
Erratum to: Smoking withdrawal is associated with increases in brain activation during decision making and reward anticipation: A preliminary study
  • DOI:
    10.1007/s00213-011-2531-x
  • 发表时间:
    2011-10-18
  • 期刊:
  • 影响因子:
    3.300
  • 作者:
    Merideth A. Addicott;David A. A. Baranger;Rachel V. Kozink;Moria J. Smoski;Gabriel S. Dichter;F. Joseph McClernon
  • 通讯作者:
    F. Joseph McClernon

Merideth A. Addicott的其他文献

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{{ truncateString('Merideth A. Addicott', 18)}}的其他基金

Reducing distress and tobacco smoking in cancer survivors: a TDCS telehealth study
减少癌症幸存者的痛苦和吸烟:TDCS 远程医疗研究
  • 批准号:
    10680370
  • 财政年份:
    2022
  • 资助金额:
    $ 19.63万
  • 项目类别:
Effects of ketamine on tobacco use disorder - Resubmission
氯胺酮对烟草使用障碍的影响 - 重新提交
  • 批准号:
    10371688
  • 财政年份:
    2022
  • 资助金额:
    $ 19.63万
  • 项目类别:
Reducing distress and tobacco smoking in cancer survivors: a TDCS telehealth study
减少癌症幸存者的痛苦和吸烟:TDCS 远程医疗研究
  • 批准号:
    10390202
  • 财政年份:
    2022
  • 资助金额:
    $ 19.63万
  • 项目类别:
Neural correlates of distress tolerance in tobacco addiction
烟草成瘾中痛苦耐受性的神经相关性
  • 批准号:
    10496770
  • 财政年份:
    2021
  • 资助金额:
    $ 19.63万
  • 项目类别:
Distress Tolerance and Smoking Cessation
痛苦耐受力和戒烟
  • 批准号:
    10405652
  • 财政年份:
    2021
  • 资助金额:
    $ 19.63万
  • 项目类别:
Distress Tolerance and Smoking Cessation
痛苦耐受力和戒烟
  • 批准号:
    10521970
  • 财政年份:
    2021
  • 资助金额:
    $ 19.63万
  • 项目类别:
Distress Tolerance and Smoking Cessation
痛苦耐受力和戒烟
  • 批准号:
    10624427
  • 财政年份:
    2021
  • 资助金额:
    $ 19.63万
  • 项目类别:
Distress Tolerance and Smoking Cessation
痛苦耐受力和戒烟
  • 批准号:
    10166818
  • 财政年份:
    2019
  • 资助金额:
    $ 19.63万
  • 项目类别:
Longitudinal Investigation of TMS as a Tool to Improve Alcohol Treatment Outcomes
TMS 作为改善酒精治疗结果工具的纵向调查
  • 批准号:
    10844805
  • 财政年份:
    2019
  • 资助金额:
    $ 19.63万
  • 项目类别:
Translational approaches to TMS treatment development for smoking
吸烟 TMS 治疗开发的转化方法
  • 批准号:
    10152574
  • 财政年份:
    2019
  • 资助金额:
    $ 19.63万
  • 项目类别:

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