Effects of ketamine on tobacco use disorder - Resubmission

氯胺酮对烟草使用障碍的影响 - 重新提交

基本信息

项目摘要

ABSTRACT Arkansas ranks third in the nation for cigarette smoking prevalence (25% of the population) and ranks second for smoking-attributed cancer mortality (33.5% mortality). More effective interventions for tobacco addiction are needed, and there is an ongoing need for non-nicotine based interventions in particular. For example, nicotine itself may potentially increase the risk of post-surgical complications. The reinforcing effects of nicotine may be due to its effects on glutamatergic transmission, and the use of glutamatergic medications for tobacco addiction has been proposed. A glutamate N-methyl-D-aspartate (NMDA) receptor antagonist, ketamine, has shown preclinical efficacy in reducing nicotine self-administration, similar to other NMDA antagonists. Furthermore, ketamine has shown promise in reducing craving, withdrawal symptoms, and use of other addictive drugs in humans. However, ketamine’s effects on tobacco use disorder are not yet known and an investigation of its impact on the neuropsychological substrates of tobacco addiction is warranted. While the effects of ketamine on tobacco addiction have not been tested in humans, there is indirect evidence of its potential efficacy to reduce tobacco use. To fill this gap in knowledge, we have begun collecting preliminary data supporting the feasibility and tolerability of ketamine in smokers who complete lab measures of cigarette craving and smoking latency before, and 24 hours after, an infusion of ketamine or placebo. To advance this line of research, we propose a within-subject, cross-over trial of smokers who will receive an infusion of ketamine and an active control drug in counter-balanced order, at least 2 weeks apart. In Aim 1, we will measure changes in craving, tobacco withdrawal, and tobacco use behavior. In Aim 2, we will determine the effects of ketamine on brain function using functional magnetic resonance imaging. The safety, tolerability, and acceptability of ketamine will be assessed using physiological, drug effect, and side-effect measures. This proposal is significant because it will be the first to translate preclinical research on a novel pharmacotherapy for tobacco addiction. This information is valuable because knowing precisely how ketamine disrupts tobacco addiction will help guide future therapeutic use of ketamine or the development of other pharmacotherapies with similar mechanisms of action.
摘要 阿肯色州的吸烟率在全国排名第三(占人口的25%), 吸烟导致的癌症死亡率(33.5%)。对烟草成瘾更有效的干预措施是 需要,特别是对基于非尼古丁的干预措施的持续需求。例如尼古丁 本身可能会增加术后并发症的风险。尼古丁的强化作用可能是 由于其对烟草能传播的影响,以及烟草能药物的使用 成瘾已经提出。一种谷氨酸N-甲基-D-天冬氨酸(NMDA)受体拮抗剂氯胺酮, 在减少尼古丁自我给药方面显示出临床前功效,与其他NMDA拮抗剂相似。 此外,氯胺酮已显示出减少渴望、戒断症状和使用其他药物的希望。 人类的成瘾药物然而,氯胺酮对烟草使用障碍的影响尚不清楚, 研究其对烟草成瘾的神经心理学基础的影响是必要的。而 氯胺酮对烟草成瘾的影响尚未在人类中进行过测试,有间接证据表明它 减少烟草使用的潜在功效。为了填补这一知识空白,我们已经开始收集初步的 支持氯胺酮在完成香烟实验室测量的吸烟者中的可行性和耐受性的数据 在输注氯胺酮或安慰剂之前和之后24小时的渴望和吸烟潜伏期。推进这一 在一项研究中,我们提出了一项受试者内交叉试验,吸烟者将接受 氯胺酮和活性对照药物以平衡顺序给药,至少间隔2周。在目标1中,我们 测量渴望、烟草戒断和烟草使用行为的变化。在目标2中,我们将确定 氯胺酮对脑功能影响的功能磁共振成像研究安全性、耐受性和 氯胺酮的可接受性将使用生理学、药物作用和副作用测量来评估。这 该提案意义重大,因为它将是第一个将临床前研究转化为新药物疗法的提案 治疗烟瘾这一信息很有价值,因为准确了解氯胺酮如何破坏烟草 成瘾将有助于指导未来氯胺酮的治疗用途或其他药物疗法的开发 具有相似的作用机制。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Merideth A. Addicott其他文献

Nicotine withdrawal induces neural and behavioral deficits in reward processing
尼古丁戒断会导致奖励处理中的神经和行为缺陷
  • DOI:
  • 发表时间:
    2017
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Jason A. Oliver;D. Evans;Merideth A. Addicott;T. Brandon;D. Drobes
  • 通讯作者:
    D. Drobes
The Effects of Dietary Caffeine Use and Abstention on Blood Oxygen Level-Dependent Activation and Cerebral Blood Flow.
膳食咖啡因的使用和戒断对血氧水平依赖性激活和脑血流量的影响。
  • DOI:
    10.1089/jcr.2011.0027
  • 发表时间:
    2012
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Merideth A. Addicott;A. Peiffer;P. Laurienti
  • 通讯作者:
    P. Laurienti
Erratum to: Smoking withdrawal is associated with increases in brain activation during decision making and reward anticipation: A preliminary study
  • DOI:
    10.1007/s00213-011-2531-x
  • 发表时间:
    2011-10-18
  • 期刊:
  • 影响因子:
    3.300
  • 作者:
    Merideth A. Addicott;David A. A. Baranger;Rachel V. Kozink;Moria J. Smoski;Gabriel S. Dichter;F. Joseph McClernon
  • 通讯作者:
    F. Joseph McClernon

Merideth A. Addicott的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Merideth A. Addicott', 18)}}的其他基金

Reducing distress and tobacco smoking in cancer survivors: a TDCS telehealth study
减少癌症幸存者的痛苦和吸烟:TDCS 远程医疗研究
  • 批准号:
    10680370
  • 财政年份:
    2022
  • 资助金额:
    $ 19.63万
  • 项目类别:
Effects of ketamine on tobacco use disorder - Resubmission
氯胺酮对烟草使用障碍的影响 - 重新提交
  • 批准号:
    10371688
  • 财政年份:
    2022
  • 资助金额:
    $ 19.63万
  • 项目类别:
Reducing distress and tobacco smoking in cancer survivors: a TDCS telehealth study
减少癌症幸存者的痛苦和吸烟:TDCS 远程医疗研究
  • 批准号:
    10390202
  • 财政年份:
    2022
  • 资助金额:
    $ 19.63万
  • 项目类别:
Neural correlates of distress tolerance in tobacco addiction
烟草成瘾中痛苦耐受性的神经相关性
  • 批准号:
    10496770
  • 财政年份:
    2021
  • 资助金额:
    $ 19.63万
  • 项目类别:
Distress Tolerance and Smoking Cessation
痛苦耐受力和戒烟
  • 批准号:
    10405652
  • 财政年份:
    2021
  • 资助金额:
    $ 19.63万
  • 项目类别:
Distress Tolerance and Smoking Cessation
痛苦耐受力和戒烟
  • 批准号:
    10521970
  • 财政年份:
    2021
  • 资助金额:
    $ 19.63万
  • 项目类别:
Distress Tolerance and Smoking Cessation
痛苦耐受力和戒烟
  • 批准号:
    10624427
  • 财政年份:
    2021
  • 资助金额:
    $ 19.63万
  • 项目类别:
Distress Tolerance and Smoking Cessation
痛苦耐受力和戒烟
  • 批准号:
    10166818
  • 财政年份:
    2019
  • 资助金额:
    $ 19.63万
  • 项目类别:
Longitudinal Investigation of TMS as a Tool to Improve Alcohol Treatment Outcomes
TMS 作为改善酒精治疗结果工具的纵向调查
  • 批准号:
    10844805
  • 财政年份:
    2019
  • 资助金额:
    $ 19.63万
  • 项目类别:
Translational approaches to TMS treatment development for smoking
吸烟 TMS 治疗开发的转化方法
  • 批准号:
    10152574
  • 财政年份:
    2019
  • 资助金额:
    $ 19.63万
  • 项目类别:

相似海外基金

How Does Particle Material Properties Insoluble and Partially Soluble Affect Sensory Perception Of Fat based Products
不溶性和部分可溶的颗粒材料特性如何影响脂肪基产品的感官知觉
  • 批准号:
    BB/Z514391/1
  • 财政年份:
    2024
  • 资助金额:
    $ 19.63万
  • 项目类别:
    Training Grant
BRC-BIO: Establishing Astrangia poculata as a study system to understand how multi-partner symbiotic interactions affect pathogen response in cnidarians
BRC-BIO:建立 Astrangia poculata 作为研究系统,以了解多伙伴共生相互作用如何影响刺胞动物的病原体反应
  • 批准号:
    2312555
  • 财政年份:
    2024
  • 资助金额:
    $ 19.63万
  • 项目类别:
    Standard Grant
RII Track-4:NSF: From the Ground Up to the Air Above Coastal Dunes: How Groundwater and Evaporation Affect the Mechanism of Wind Erosion
RII Track-4:NSF:从地面到沿海沙丘上方的空气:地下水和蒸发如何影响风蚀机制
  • 批准号:
    2327346
  • 财政年份:
    2024
  • 资助金额:
    $ 19.63万
  • 项目类别:
    Standard Grant
Graduating in Austerity: Do Welfare Cuts Affect the Career Path of University Students?
紧缩毕业:福利削减会影响大学生的职业道路吗?
  • 批准号:
    ES/Z502595/1
  • 财政年份:
    2024
  • 资助金额:
    $ 19.63万
  • 项目类别:
    Fellowship
感性個人差指標 Affect-X の構築とビスポークAIサービスの基盤確立
建立个人敏感度指数 Affect-X 并为定制人工智能服务奠定基础
  • 批准号:
    23K24936
  • 财政年份:
    2024
  • 资助金额:
    $ 19.63万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Insecure lives and the policy disconnect: How multiple insecurities affect Levelling Up and what joined-up policy can do to help
不安全的生活和政策脱节:多种不安全因素如何影响升级以及联合政策可以提供哪些帮助
  • 批准号:
    ES/Z000149/1
  • 财政年份:
    2024
  • 资助金额:
    $ 19.63万
  • 项目类别:
    Research Grant
How does metal binding affect the function of proteins targeted by a devastating pathogen of cereal crops?
金属结合如何影响谷类作物毁灭性病原体靶向的蛋白质的功能?
  • 批准号:
    2901648
  • 财政年份:
    2024
  • 资助金额:
    $ 19.63万
  • 项目类别:
    Studentship
Investigating how double-negative T cells affect anti-leukemic and GvHD-inducing activities of conventional T cells
研究双阴性 T 细胞如何影响传统 T 细胞的抗白血病和 GvHD 诱导活性
  • 批准号:
    488039
  • 财政年份:
    2023
  • 资助金额:
    $ 19.63万
  • 项目类别:
    Operating Grants
New Tendencies of French Film Theory: Representation, Body, Affect
法国电影理论新动向:再现、身体、情感
  • 批准号:
    23K00129
  • 财政年份:
    2023
  • 资助金额:
    $ 19.63万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
The Protruding Void: Mystical Affect in Samuel Beckett's Prose
突出的虚空:塞缪尔·贝克特散文中的神秘影响
  • 批准号:
    2883985
  • 财政年份:
    2023
  • 资助金额:
    $ 19.63万
  • 项目类别:
    Studentship
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了