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Translational approaches to TMS treatment development for smoking

Translational approaches to TMS treatment development for smoking
吸烟 TMS 治疗开发的转化方法
批准号:
10152574
负责人:
Merideth A. Addicott
金额:
$62.53万
依托单位国家:
美国
项目类别:
财政年份:
2019
资助国家:
美国
项目状态:
已结题
起止时间:
2019-11-06 至 2024-08-31

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项目成果

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中文摘要
翻译
项目总结/文摘
英文摘要
PROJECT SUMMARY/ABSTRACT Smoking is the leading preventable cause of mortality and morbidity in the United States, each year contributing to approximately 443,000 deaths. Smoking and high relapse rates are likely due to factors that affect both limbic and executive circuits in the brain, including vulnerability to salient smoking-related cues and loss of cognitive control. Accumulating evidence indicates that in addiction, the frontal-striatal circuits involved in limbic reward and impulsive action are relatively hyperactive, while the executive control circuits are relatively hypoactive. Thus, intervention efforts should be directed at either decreasing the relative activity of the impulsive reward circuit or increasing the relative activity of the executive control circuits. Transcranial magnetic stimulation (TMS) is a non-invasive, FDA-approved treatment for depression which is also being investigated for as a possible treatment for smoking cessation. The goal of this project is to use the novel theta burst stimulation (TBS) protocol to induce sustainable decreases and increases in the impulsive and executive control circuits, respectively. To do so, we will apply an attenuating form of TBS to the ventromedial prefrontal cortex to target the impulsive reward circuit and a potentiating form of TBS to the dorsolateral prefrontal cortex to target the executive control circuit. We will then investigate the efficacy of these protocols for reducing a range of smoking measures, including cigarette valuation, delay discounting, cigarette self-administration, and brain reactivity to smoking cues. The results from these investigations will pave a clear pathway for the systematic development of neural-circuit based strategies as treatments for tobacco use and dependence.
期刊论文(2)
专著(0)
科研奖励(0)
会议论文
The relationship between nonsystematic delay discounting and low-quality survey responses in a sample of smokers: ROC curve analysis.
吸烟者样本中非系统性延迟贴现与低质量调查响应之间的关系:ROC 曲线分析。
DOI: 10.1037/pha0000584
发表时间: 2023
期刊: Experimental and clinical psychopharmacology
影响因子: 2.3
作者: [Yeh,Yu-Hua, Freitas-Lemos,Roberta, Craft,WilliamH, Bickel,WarrenK]
通讯作者: Bickel,WarrenK
Reducing distress and tobacco smoking in cancer survivors: a TDCS telehealth study
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Reducing distress and tobacco smoking in cancer survivors: a TDCS telehealth study
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