Molecular Transducers of Physical Activity Consortium Coordinating Center

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Project Summary The Molecular Transducers of Physical Activity Consortium (MoTrPAC) was established to discover the molecular transducers of endurance and resistance exercise. The Consortium Coordinating Center (CCC), composed of the Administrative Coordinating Core (ACC), the Biospecimens Repository Core (BRC), the Exercise Intervention Core (EIC), and the Data Management, Analysis and Quality Control (DMAQC) Core provides expertise, personnel, and information technology (IT) solutions to support the organization, administration, planning, standardization, documentation, monitoring, analysis, and reporting of all MoTrPAC activities. These functions require working closely with the Clinical Sites, the Preclinical Animal Study Sites (PASS), Ancillary Studies, the Bioinformatics Center (BIC), the Chemical Analysis Sites (CAS), as well as subcommittees and working groups (WGs). The CCC has developed strategies and processes designed to integrate activities of MoTrPAC investigators with the input provided by the Data and Safety Monitoring Board (DSMB), outside experts, and the National Institutes of Health (NIH). The CCC is led by four highly qualified PIs including Dr. Miller at Wake Forest University School of Medicine (WFUSM) who leads the DMAQC Core and manages clinical data and safety-related activities, Dr. Tracy at the University of Vermont (UVM) who vice- chairs the MoTrPAC Steering Committee (SC) and leads the BRC, Dr. Rejeski who resides on the academic campus of Wake Forest University and leads the EIC, and Dr. Esser who leads the ACC at the University of Florida and oversees an administrative staff that is the core for managing Consortium-wide communications, setting-up annual meetings, and supporting subcommittees and WGs. WFUSM is the hub of the CCC, with the DMAQC Core staff providing project management, computing, and analytical support for all other components of the CCC. The EIC also assists the DMAQC Core with safety-related activities and is highly integrated with project managers within the DMAQC Core for supporting clinic-related functions such as Manuals of Procedures (MOPs), phenotypic measures, certification of interventionists and assessors, and site visits. The CCC will continue to employ innovative project management tools, programming, and web-based tracking of recruitment and retention (R&R), interventions, and assessments in real-time. We will capitalize on the outstanding track record in successfully coordinating, managing, and leading large long-term multicenter clinical trials involving exercise and other interventions to accomplish the following: (a) facilitate team science; (b) implement rigor, reproducibility, and transparency in research; (d) acquire, manage, store, and distribute biological samples for analysis; (e) conduct and coordinate preclinical exercise studies; (f) share resources; (g) publish results; and (h) lead multidisciplinary teams to implement best-practices for analytical methods applied to randomized studies. The CCC will facilitate the continued success of MoTrPAC in advancing knowledge regarding the molecular transducers of exercise as related to public health.