Molecular Transducers of Physical Activity Consortium Coordinating Center

体力活动分子传感器联盟协调中心

基本信息

  • 批准号:
    10840609
  • 负责人:
  • 金额:
    $ 310万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2017
  • 资助国家:
    美国
  • 起止时间:
    2017-08-01 至 2026-08-31
  • 项目状态:
    未结题

项目摘要

Project Summary The Molecular Transducers of Physical Activity Consortium (MoTrPAC) was established to discover the molecular transducers of endurance and resistance exercise. The Consortium Coordinating Center (CCC), composed of the Administrative Coordinating Core (ACC), the Biospecimens Repository Core (BRC), the Exercise Intervention Core (EIC), and the Data Management, Analysis and Quality Control (DMAQC) Core provides expertise, personnel, and information technology (IT) solutions to support the organization, administration, planning, standardization, documentation, monitoring, analysis, and reporting of all MoTrPAC activities. These functions require working closely with the Clinical Sites, the Preclinical Animal Study Sites (PASS), Ancillary Studies, the Bioinformatics Center (BIC), the Chemical Analysis Sites (CAS), as well as subcommittees and working groups (WGs). The CCC has developed strategies and processes designed to integrate activities of MoTrPAC investigators with the input provided by the Data and Safety Monitoring Board (DSMB), outside experts, and the National Institutes of Health (NIH). The CCC is led by four highly qualified PIs including Dr. Miller at Wake Forest University School of Medicine (WFUSM) who leads the DMAQC Core and manages clinical data and safety-related activities, Dr. Tracy at the University of Vermont (UVM) who vice- chairs the MoTrPAC Steering Committee (SC) and leads the BRC, Dr. Rejeski who resides on the academic campus of Wake Forest University and leads the EIC, and Dr. Esser who leads the ACC at the University of Florida and oversees an administrative staff that is the core for managing Consortium-wide communications, setting-up annual meetings, and supporting subcommittees and WGs. WFUSM is the hub of the CCC, with the DMAQC Core staff providing project management, computing, and analytical support for all other components of the CCC. The EIC also assists the DMAQC Core with safety-related activities and is highly integrated with project managers within the DMAQC Core for supporting clinic-related functions such as Manuals of Procedures (MOPs), phenotypic measures, certification of interventionists and assessors, and site visits. The CCC will continue to employ innovative project management tools, programming, and web-based tracking of recruitment and retention (R&R), interventions, and assessments in real-time. We will capitalize on the outstanding track record in successfully coordinating, managing, and leading large long-term multicenter clinical trials involving exercise and other interventions to accomplish the following: (a) facilitate team science; (b) implement rigor, reproducibility, and transparency in research; (d) acquire, manage, store, and distribute biological samples for analysis; (e) conduct and coordinate preclinical exercise studies; (f) share resources; (g) publish results; and (h) lead multidisciplinary teams to implement best-practices for analytical methods applied to randomized studies. The CCC will facilitate the continued success of MoTrPAC in advancing knowledge regarding the molecular transducers of exercise as related to public health.
项目总结

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Karyn A Esser其他文献

Erratum to: Inducible Cre transgenic mouse strain for skeletal muscle-specific gene targeting
  • DOI:
    10.1186/2044-5040-2-22
  • 发表时间:
    2012-10-30
  • 期刊:
  • 影响因子:
    4.400
  • 作者:
    John J McCarthy;Ratchakrit Srikuea;Tyler J Kirby;Charlotte A Peterson;Karyn A Esser
  • 通讯作者:
    Karyn A Esser

Karyn A Esser的其他文献

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{{ truncateString('Karyn A Esser', 18)}}的其他基金

MoTrPAC Supplemental Funding for Miller
MoTrPAC 为米勒提供补充资金
  • 批准号:
    10889549
  • 财政年份:
    2023
  • 资助金额:
    $ 310万
  • 项目类别:
Muscle clock and weakness: diversity supplement
肌肉时钟和弱点:多样性补充
  • 批准号:
    10414186
  • 财政年份:
    2021
  • 资助金额:
    $ 310万
  • 项目类别:
Circadian Clock and Muscle Health
昼夜节律时钟和肌肉健康
  • 批准号:
    10372227
  • 财政年份:
    2021
  • 资助金额:
    $ 310万
  • 项目类别:
Circadian Clock and Muscle Health
昼夜节律时钟和肌肉健康
  • 批准号:
    10583484
  • 财政年份:
    2021
  • 资助金额:
    $ 310万
  • 项目类别:
Circadian Clock and Muscle Health
昼夜节律时钟和肌肉健康
  • 批准号:
    10796287
  • 财政年份:
    2021
  • 资助金额:
    $ 310万
  • 项目类别:
Circadian Clock and Muscle Health
昼夜节律时钟和肌肉健康
  • 批准号:
    10581006
  • 财政年份:
    2021
  • 资助金额:
    $ 310万
  • 项目类别:
MoTrPAC Consortium Coordinating Center
MoTrPAC 联盟协调中心
  • 批准号:
    10322175
  • 财政年份:
    2016
  • 资助金额:
    $ 310万
  • 项目类别:
UF PASS: Regulation of exercise transducers
UF PASS:运动传感器的调节
  • 批准号:
    10341087
  • 财政年份:
    2016
  • 资助金额:
    $ 310万
  • 项目类别:
UF PASS: Regulation of exercise transducers
UF PASS:运动传感器的调节
  • 批准号:
    9515180
  • 财政年份:
    2016
  • 资助金额:
    $ 310万
  • 项目类别:
UF PASS Administrative Supplement: Regulation of exercise transducers
UF PASS 行政补充:运动传感器的监管
  • 批准号:
    10746522
  • 财政年份:
    2016
  • 资助金额:
    $ 310万
  • 项目类别:

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