Molecular Transducers of Physical Activity Consortium Coordinating Center
体力活动分子传感器联盟协调中心
基本信息
- 批准号:10840609
- 负责人:
- 金额:$ 310万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2017
- 资助国家:美国
- 起止时间:2017-08-01 至 2026-08-31
- 项目状态:未结题
- 来源:
- 关键词:AcuteAdherenceAncillary StudyAnimalsAttentionAwardBioinformaticsBiologicalBiological ProcessBiological Specimen BanksCertificationChemicalsChronicClinicClinical DataClinical DistributionClinical ManagementClinical Trials Data Monitoring CommitteesCollaborationsCollectionCommunicationCommunitiesDataDevelopmentDisease OutcomeDocumentationEnsureExerciseFloridaFosteringFundingFutureGoalsHealthHealth BenefitHealth systemHuman ResourcesInformation TechnologyInstitutional Review BoardsInterventionKnowledgeLeadLeadershipManualsMapsMeasuresMolecularMonitorMulti-Institutional Clinical TrialMulti-site clinical studyOnline SystemsOrganization and AdministrationPathway interactionsPatient RecruitmentsPhenotypePhysical activityProceduresProcessProgress ReportsProtocols documentationPublic HealthPublicationsPublishingQualifyingQuality ControlRandomizedRecording of previous eventsReportingReproducibilityResearchResearch DesignResearch PersonnelResource SharingResourcesSafetySamplingScheduleScienceShippingSiteSite VisitStandardizationStructureTechnologyTimeTissuesTrainingTransducersUnited States National Institutes of HealthUniversitiesVermontanalytical methodbiological systemsclinical centerclinical research sitedata managementdata sharingdesigndevelopment policyendurance exerciseexercise interventionexercise trainingexperienceforestimprovedinnovationmedical schoolsmeetingsmultidisciplinarymultiple omicsparticipant retentionphenotypic datapre-clinicalrecruitresistance exerciseresponsesuccesssynergismtoolworking group
项目摘要
Project Summary
The Molecular Transducers of Physical Activity Consortium (MoTrPAC) was established to discover the
molecular transducers of endurance and resistance exercise. The Consortium Coordinating Center (CCC),
composed of the Administrative Coordinating Core (ACC), the Biospecimens Repository Core (BRC), the
Exercise Intervention Core (EIC), and the Data Management, Analysis and Quality Control (DMAQC) Core
provides expertise, personnel, and information technology (IT) solutions to support the organization,
administration, planning, standardization, documentation, monitoring, analysis, and reporting of all MoTrPAC
activities. These functions require working closely with the Clinical Sites, the Preclinical Animal Study Sites
(PASS), Ancillary Studies, the Bioinformatics Center (BIC), the Chemical Analysis Sites (CAS), as well as
subcommittees and working groups (WGs). The CCC has developed strategies and processes designed to
integrate activities of MoTrPAC investigators with the input provided by the Data and Safety Monitoring Board
(DSMB), outside experts, and the National Institutes of Health (NIH). The CCC is led by four highly qualified
PIs including Dr. Miller at Wake Forest University School of Medicine (WFUSM) who leads the DMAQC Core
and manages clinical data and safety-related activities, Dr. Tracy at the University of Vermont (UVM) who vice-
chairs the MoTrPAC Steering Committee (SC) and leads the BRC, Dr. Rejeski who resides on the academic
campus of Wake Forest University and leads the EIC, and Dr. Esser who leads the ACC at the University of
Florida and oversees an administrative staff that is the core for managing Consortium-wide communications,
setting-up annual meetings, and supporting subcommittees and WGs. WFUSM is the hub of the CCC, with the
DMAQC Core staff providing project management, computing, and analytical support for all other components
of the CCC. The EIC also assists the DMAQC Core with safety-related activities and is highly integrated with
project managers within the DMAQC Core for supporting clinic-related functions such as Manuals of
Procedures (MOPs), phenotypic measures, certification of interventionists and assessors, and site visits. The
CCC will continue to employ innovative project management tools, programming, and web-based tracking of
recruitment and retention (R&R), interventions, and assessments in real-time. We will capitalize on the
outstanding track record in successfully coordinating, managing, and leading large long-term multicenter
clinical trials involving exercise and other interventions to accomplish the following: (a) facilitate team science;
(b) implement rigor, reproducibility, and transparency in research; (d) acquire, manage, store, and distribute
biological samples for analysis; (e) conduct and coordinate preclinical exercise studies; (f) share resources; (g)
publish results; and (h) lead multidisciplinary teams to implement best-practices for analytical methods applied
to randomized studies. The CCC will facilitate the continued success of MoTrPAC in advancing knowledge
regarding the molecular transducers of exercise as related to public health.
项目摘要
身体活动的分子传感器联盟(MoTrPAC)的成立是为了发现
耐力和抗阻运动的分子传感器。联盟协调中心(CCC),
由行政协调核心(ACC)、生物标本库核心(BRC)、
运动干预核心(EIC)和数据管理、分析和质量控制(DMAQC)核心
提供专业知识、人员和信息技术(IT)解决方案以支持组织,
所有交通部公共行政管理、规划、标准化、文件编制、监测、分析和报告
活动这些职能需要与临床研究中心、临床前动物研究中心
(PASS),辅助研究,生物信息学中心(BIC),化学分析中心(CAS),以及
小组委员会和工作组。CCC制定了战略和程序,
将交通和公共工程部调查人员的活动与数据和安全监测委员会提供的信息相结合
(DSMB),外部专家和美国国立卫生研究院(NIH)。CCC由四位高素质的
PI,包括维克森林大学医学院(WFUSM)的米勒博士,他领导DMAQC核心
并管理临床数据和安全相关活动,佛蒙特大学(UVM)的Tracy博士,
主持MoTrPAC指导委员会(SC)并领导BRC,Rejeski博士居住在学术
维克森林大学的校园,并领导EIC,和埃塞尔博士谁领导的ACC在大学
佛罗里达,并监督行政人员,这是管理全联盟通信的核心,
设立年度会议,并支持小组委员会和工作组。WFUSM是CCC的中心,
DMAQC核心员工为所有其他组件提供项目管理、计算和分析支持
的CCC。EIC还协助DMAQC核心进行安全相关活动,并与
DMAQC核心内的项目经理,用于支持临床相关功能,例如
程序(MOPs)、表型测量、干预人员和评估人员的认证以及现场访视。的
CCC将继续采用创新的项目管理工具、编程和基于网络的跟踪,
招聘和保留(R&R),干预和实时评估。我们将利用
在成功协调、管理和领导大型长期多中心研究方面有着出色的记录
涉及运动和其他干预措施的临床试验,以实现以下目标:(a)促进团队科学;
(b)在研究中实现严格性、可重复性和透明度;(d)获取、管理、存储和分发
生物样本进行分析;(e)进行和协调临床前演习研究;(f)共享资源;(g)
公布结果;(h)领导多学科小组实施所用分析方法的最佳做法
随机研究。气候变化共同核心委员会将促进交通和公共工程部在增进知识方面继续取得成功
关于运动的分子传感器与公共健康的关系。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Karyn A Esser其他文献
Erratum to: Inducible Cre transgenic mouse strain for skeletal muscle-specific gene targeting
- DOI:
10.1186/2044-5040-2-22 - 发表时间:
2012-10-30 - 期刊:
- 影响因子:4.400
- 作者:
John J McCarthy;Ratchakrit Srikuea;Tyler J Kirby;Charlotte A Peterson;Karyn A Esser - 通讯作者:
Karyn A Esser
Karyn A Esser的其他文献
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{{ truncateString('Karyn A Esser', 18)}}的其他基金
UF PASS Administrative Supplement: Regulation of exercise transducers
UF PASS 行政补充:运动传感器的监管
- 批准号:
10746522 - 财政年份:2016
- 资助金额:
$ 310万 - 项目类别:
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