UF PASS: Regulation of exercise transducers: supplement for diverse students

翻译后摘要：本研究补充的目的是促进健康相关研究的多样性 通过支持布赖恩阿拉瓦，目前在博士生的职业发展培训， 佛罗里达大学。这份行政补助将有助于候选人的职业发展 同时也有助于完成母项目的使命--发现新的运动诱发健康 相关成果。母公司奖是MoTrPAC联盟的一部分，该联盟结合了定义明确的 运动干预与多组学分析，以开发一个地图的分子传感器， 锻炼身体，促进全身健康。到目前为止，该联盟正在分析17个不同国家的多组学数据。 作为临床前研究的一部分，按照规定的跑步机运动模式收集组织。 阿拉瓦先生提出的研究的主要目标有两个方面：首先，使用一个定义的阿尔茨海默氏症， 疾病（AD）小鼠模型，以表征骨骼肌功能和血液标志物的变化。 炎症和新陈代谢。其次，一旦特征化，我们将使用此模型来测试跑步机 基于MoTrPAC所用方案的培训方案，用于延迟 AD.我们还将能够访问MoTrPAC提供的更大的多组学数据， 运动和AD病理学的潜在分子靶点。U 01的PI Esser博士将是两名 阿拉瓦先生的主要导师Jose Abisambra博士是另一位共同导师，因为他的实验室提供AD 小鼠模型和大脑病理学分析方面的专业知识。埃塞尔博士和阿比桑布拉已经 布莱恩·阿拉瓦博士的正式导师生理学系的课程， 佛罗里达大学医学院的功能基因组学。我们已经概述了一个 一系列教学和体验式培训活动，使Alava先生具备必要的技能， 作为一个独立的科学家的进步，并履行国家卫生研究院的使命，以促进职业生涯的多样化 科学家的人口。

Abstract: The purpose of this Research Supplement is to Promote Diversity in Health-Related Research through support of the career development training for Bryan Alava, a current PhD student at the University of Florida. This administrative supplement will facilitate career development for the candidate and as well as contribute to the mission of the parent project - to discover novel exercise induced health related outcomes. The parent award is part of the MoTrPAC consortium that combines well defined exercise interventions with multi-omics analysis to develop a map of molecular transducers that link exercise to systemic health. To date, the consortium is analyzing the multi-omics data across 17 different tissues collected following a defined treadmill exercise paradigm as part of the preclinical studies. The primary objectives of Mr. Alava’s proposed research are two-fold: First to use a defined Alzheimer’s Disease (AD) mouse model to characterize changes in skeletal muscle function and blood markers of inflammation and metabolism. Second, once characterized we will use this model to test a treadmill training protocol, based on the protocol used for MoTrPAC, for efficacy in delaying the progression of AD. We will also be in a position to access the larger multiomics data available from MoTrPAC to expand potential molecular targets of exercise and AD pathology. Dr. Esser, the PI of the U01, will be one of two primary mentors for Mr. Alava. Dr. Jose Abisambra is the other co-mentor as his lab provides the AD mouse model and expertise in the analysis of brain pathologies. Drs. Esser and Abisambra are already official co-mentors for Bryan Alava within the Ph.D. program in the Department of Physiology and Functional Genomics within the College of Medicine at the University of Florida. We have outlined a series of didactic and experiential training activities that will equip Mr. Alava with the necessary skills to progress as an independent scientist and to fulfill the NIH mission to advance the careers of a diverse population of scientists.