MoTrPAC Consortium Coordinating Center

MoTrPAC 联盟协调中心

• 批准号: 10322175
• 负责人: Karyn A Esser
• 金额: --
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-12-06 至 2023-09-23
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10322175
• 关键词: Adherence; Age; Animals; Awareness; Bioinformatics; Biological; Biological Specimen Banks; Chemicals; Clinical; Clinical Data; Clinical Trials Data Monitoring Committees; Communication; Data; Data Collection; Data Storage and Retrieval; Diet; Documentation; Ensure; Exercise; Fostering; Funding Opportunities; Future; Goals; Health; Health Benefit; Human; Intervention; Knowledge; Leadership; Maps; Molecular; Molecular Target; Monitor; Multi-Institutional Clinical Trial; Online Systems; Organization and Administration; Outcome; Patient Recruitments; Persons; Pharmacology; Physical activity; Play; Policies; Population; Preparation; Procedures; Process; Productivity; Progress Reports; Protocols documentation; Public Health; Public Relations; Publications; Publishing; Quality Control; Reporting; Research; Research Design; Research Personnel; Resource Sharing; Resources; Role; Safety; Sampling; Schedule; Science; Services; Shipping; Site; Standardization; Strategic Planning; Technology; Teleconferences; Time; TimeLine; Training; Transducers; United States National Institutes of Health; Work; animal data; clinical center; clinical research site; cohesion; data access; data acquisition; data management; data sharing; diet and exercise; endurance exercise; exercise adherence; exercise intervention; innovation; meetings; multidisciplinary; physical inactivity; pre-clinical; programs; public health relevance; resistance exercise; response; success; synergism; theories; tool; web portal

Summary Physical inactivity is a major public health challenge underlying a broad range of health problems at all ages. While physical activity (PA) has shown to produce relevant health benefits, the underlying molecular mechanisms are poorly known. The coordinated effort of clinical and animal studies supported by bioinformatics and chemical analyses will achieve the Molecular Transducers of Physical Activity Consortium (MoTrPAC) goals of assessing the molecular changes that occur in response to PA. The Consortium Coordinating Center (CCC) for the MoTrPAC will provide support for the organization, administration, planning, standardization, documentation, monitoring and reporting activities relating to the MoTrPAC. The CCC will play a pivotal role in ensuring the cohesion of the MoTrPAC by enhancing communication and integration across all study components, including the Clinical Sites, the Preclinical Animal Study Sites, the Bioinformatics Center, the Chemical Analysis Sites, and the various study committees. The CCC will develop strategies and strategic planning processes by integrating activities of the MoTrPAC investigators with the input provided by the Data Safety Monitoring Board, the External Scientific Advisors, outside experts, and the NIH. The CCC will facilitate interactions and communications with junior and senior investigators outside the consortium to maximize the use of the MoTrPAC resources toward achieving the overall research goals. To accomplish these goals and maximize the progress and productivity of the MoTrPAC, the CCC will promote team science, team leadership, and innovative leadership approaches across all study components. Strategic planning that follows the principles of the dynamic theory of strategy will be fostered to evaluate alternative approaches, maintain the cutting-edge scientific focus, leverage state-of-the-art coordination technologies, anticipate challenges, and maximize future opportunities to ensure the success of the consortium. The CCC will comprise four integrated components led by four highly qualified PIs who have a long-lasting track record of successfully working in synergy. The four CCC components comprise the Administrative Coordinating Center (PI Dr. Pahor), the Data Management, Analysis, and Quality Control Center (PI Dr. Miller), the Biospecimens Repository (PI Dr. Tracy), and the Exercise Intervention Core (PI Dr. Rejeski). The CCC will employ innovative project management tools and web-based tracking of exercise adherence and diet, and will capitalize on the outstanding track record and expertise of its investigators in: (a) working together; (b) successfully coordinating, managing, and leading large long-term multicenter clinical trials involving PA and other interventions; (c) implementing rigor and transparency in research, (d) acquiring, managing, storing and analyzing biological samples; (e) conducting animal exercise studies; (f) sharing resources; (g) publishing results; and (h) leading multidisciplinary teams. The CCC will ensure and promote the continued success of the MoTrPAC in advancing knowledge about the molecular changes that occur in response to PA, and relating these changes to the health benefits of PA.

概括 缺乏身体活动是一项重大的公共卫生挑战，是所有年龄段的一系列广泛健康问题的根源。 虽然身体活动 (PA) 已被证明可以产生相关的健康益处，但其潜在的分子机制 机制鲜为人知。临床和动物研究的协调努力支持 生物信息学和化学分析将实现体力活动联盟的分子传感器 (MoTrPAC) 的目标是评估 PA 反应中发生的分子变化。财团 MoTrPAC 协调中心 (CCC) 将为组织、管理、规划、 与 MoTrPAC 相关的标准化、记录、监测和报告活动。 CCC将进行比赛 通过加强所有部门的沟通和整合，在确保 MoTrPAC 凝聚力方面发挥关键作用 研究组成部分，包括临床中心、临床前动物研究中心、生物信息学中心、 化学分析站点和各个研究委员会。 CCC将制定战略和战略 通过将 MoTrPAC 研究人员的活动与数据提供的输入相结合来规划流程 安全监测委员会、外部科学顾问、外部专家和 NIH。 CCC 将促进 与联盟外部的初级和高级研究人员进行互动和沟通，以最大限度地提高 使用 MoTrPAC 资源来实现总体研究目标。为了实现这些目标并 为了最大限度地提高 MoTrPAC 的进步和生产力，CCC 将促进团队科学、团队领导力、 以及跨所有研究组成部分的创新领导方法。战略规划遵循 将培养战略动态理论的原则来评估替代方法，维持 前沿的科学焦点，利用最先进的协调技术，预测挑战，以及 最大限度地利用未来的机会，确保联盟的成功。 CCC 将由四个综合 由四位高素质的 PI 领导的组件，他们拥有长期成功工作的记录 协同作用。 CCC 的四个组成部分包括行政协调中心 (PI Dr. Pahor)、数据中心 管理、分析和质量控制中心（PI Dr. Miller）、生物样本库（PI Dr. Tracy）、 和运动干预核心（PI Dr. Rejeski）。 CCC 将采用创新的项目管理工具 以及基于网络的运动坚持和饮食跟踪，并将利用出色的跟踪记录和 调查人员在以下方面的专业知识： (a) 共同努力； (b) 成功地协调、管理和领导 涉及 PA 和其他干预措施的大型长期多中心临床试验； (c) 严格执行 研究的透明度，(d) 获取、管理、储存和分析生物样本； (e) 进行 动物运动研究； (f) 共享资源； (g) 公布结果； (h) 领导多学科团队。 CCC 将确保并促进 MoTrPAC 在推进有关 PA 反应而发生的分子变化，并将这些变化与 PA 的健康益处相关联。