Supplement to Neurobiological Engineering Training Program

神经生物工程培训计划的补充

• 批准号: 10836872
• 负责人: Alan Jasanoff
• 金额: $ 5.38万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-05-01 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10836872
• 关键词: Engineering; Neurobiology; Training Programs

SUMMARY The mission of the NBETP is to train early-mid stage graduate students to become future leaders at the interface between neurobiology and engineering. This is accomplished via a blend of course requirements in neuroscience and engineering, including several dedicated neurotech- nology classes, as well as through mentorship and community-associated events that encourage student leadership and career development. Students admitted into the program are selected based on intellectual caliber, leadership potential, commitment to neurobiological engineering research, willingness to take on risky and potentially game-changing projects, and diversity. Stu- dents are engaged in innovation of emerging bioengineered technologies that enable fundamen- tal biological discoveries with translational potential related to a broad spectrum of neurobiolog- ical diseases including neuropsychiatric and neurological conditions, as well as addiction. Goals of the program are thus very well aligned to the objectives of NIBIB-funded T32 grants and to the mission of NIBIB overall, and they also synergize with interests of ICs such as NIMH, NINDS, and NIDA. An administrative structure oversees the training program's direction, student admis- sion, and assessments. Preceptors associated with the NBETP include a set of faculty with di- verse, multidisciplinary expertise encompassing multiple departments and intersection of multi- ple traditional disciplines such as bioengineering, electrical engineering, chemistry, and neuro- biology. The program thus closely fits the profile of a “broad-based NRSA training program,” as described in NOT-EB-07-005. Funding currently provides for four predoctoral students to partic- ipate in the program for two years each. In its first five years, the program has attracted a diverse set of trainees and offered them important and enriching experiences during and after their funded periods. The program has also contributed to substantial research and leadership ac- complishments by individual trainees, as well as to significant expansion of the footprint and visibility of neuroengineering research and education at MIT and beyond. In the next five years, if our renewal application is supported, we will have exciting opportunities to enhance the pro- gram, develop further experiences for our trainees, and begin to observe outcomes following graduation of our first cohorts of trainees. We hope that the program can be renewed with further funding from the NIH, and we are confident that the program can continue to offer outstanding benefits to our trainees and to the broader community.

概括 NBETP的使命是培养早期中期研究生成为未来的领导者 处于神经生物学和工程学之间的界面。这是通过混合实现的 神经科学和工程学的课程要求，包括几个专门的神经技术- 科学课程，以及通过指导和社区相关活动鼓励 学生领导力和职业发展。选择被录取的学生 基于智力素质、领导潜力、对神经生物工程的承诺 研究、愿意承担风险和可能改变游戏规则的项目以及多样性。斯图- dents 致力于新兴生物工程技术的创新，这些技术使基础 与广泛的神经生物学相关的具有转化潜力的所有生物学发现 疾病，包括神经精神和神经系统疾病以及成瘾。目标 因此，该计划的内容与 NIBIB 资助的 T32 赠款的目标非常一致，并且 NIBIB 的总体使命，并且它们还与 NIMH、NINDS 等 IC 的利益产生协同作用， 和奈达。行政结构负责监督培训计划的方向、学生入学情况 和评估。与 NBETP 相关的导师包括一组具有不同专业背景的教师。 反过来，跨学科的专业知识涵盖多个部门和多学科的交叉点 生物工程、电气工程、化学和神经工程等传统学科 生物学。因此，该计划非常符合“基础广泛的 NRSA 培训计划”的概况，因为 NOT-EB-07-005 中描述。目前资助四名博士生参加- 每人参加该计划两年。在最初的五年里，该计划吸引了多元化的 一组受训者，并为他们在培训期间和培训结束后提供了重要且丰富的经验 资助期间。该计划还为实质性研究和领导活动做出了贡献 个别受训者的成就，以及足迹的显着扩大和 麻省理工学院及其他地方的神经工程研究和教育的知名度。未来五年， 如果我们的续签申请得到支持，我们将有令人兴奋的机会来增强亲 克，为我们的学员发展进一步的经验，并开始观察以下结果 我们的第一批学员毕业。我们希望该计划能够得到进一步更新 来自 NIH 的资助，我们相信该计划能够继续提供出色的 使我们的学员和更广泛的社区受益。

项目成果

Reward magnitude tracking by neural populations in ventral striatum.

• DOI: 10.1016/j.neuroimage.2016.10.036
• 发表时间: 2017-02-01
• 期刊: NeuroImage
• 影响因子: 5.7
• 作者: Fiallos AM;Bricault SJ;Cai LX;Worku HA;Colonnese MT;Westmeyer GG;Jasanoff A
• 通讯作者: Jasanoff A

Interleukin-6 deficiency exacerbates Huntington's disease model phenotypes.

Interleukin-6 缺乏会加剧亨廷顿病模型表型。

• DOI: 10.1186/s13024-020-00379-3
• 发表时间: 2020
• 期刊: Molecular neurodegeneration
• 影响因子: 15.1
• 作者: Wertz,MaryH;Pineda,SSebastian;Lee,Hyeseung;Kulicke,Ruth;Kellis,Manolis;Heiman,Myriam
• 通讯作者: Heiman,Myriam

Probing the brain with molecular fMRI.

• DOI: 10.1016/j.conb.2018.03.009
• 发表时间: 2018-06
• 期刊: Current opinion in neurobiology
• 影响因子: 5.7
• 作者: Ghosh S;Harvey P;Simon JC;Jasanoff A
• 通讯作者: Jasanoff A

Simple, Scalable Proteomic Imaging for High-Dimensional Profiling of Intact Systems.

简单，可扩展的蛋白质组学成像，用于完整系统的高维分析。

• DOI: 10.1016/j.cell.2015.11.025
• 发表时间: 2015-12-03
• 期刊: Cell
• 影响因子: 64.5
• 作者: Murray E;Cho JH;Goodwin D;Ku T;Swaney J;Kim SY;Choi H;Park YG;Park JY;Hubbert A;McCue M;Vassallo S;Bakh N;Frosch MP;Wedeen VJ;Seung HS;Chung K
• 通讯作者: Chung K

Multifunctional fibers enable modulation of cortical and deep brain activity during cognitive behavior in macaques.

• DOI: 10.1126/sciadv.adh0974
• 发表时间: 2023-10-06
• 期刊: SCIENCE ADVANCES
• 影响因子: 13.6
• 作者: Garwood, Indie C.;Major, Alex J.;Antonini, Marc-Joseph;Correa, Josefina;Lee, Youngbin;Sahasrabudhe, Atharva;Mahnke, Meredith K.;Miller, Earl K.;Brown, Emery N.;Anikeeva, Polina
• 通讯作者: Anikeeva, Polina