IMAT-ITCR Collaboration: Artificial intelligence enhanced breast cancer dormancy cell classification-based organelle-morphology and topology

IMAT-ITCR 合作:人工智能增强乳腺癌休眠细胞分类的细胞器形态和拓扑

基本信息

  • 批准号:
    10884759
  • 负责人:
  • 金额:
    $ 8.15万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-09-01 至 2024-08-31
  • 项目状态:
    已结题

项目摘要

ABSTRACT Breast cancer is a highly heterogenous disease, both phenotypically and genetically. The quantity and subcellular location of cancer protein biomarkers are used to classify breast cancer types. Transcriptomics, multiplexed imaging, or mass cytometry have been used to classify breast tumor cell heterogeneity with varying success. Although genomics and proteomics have been successful in the identification of tumor cell populations involved in metastatic progression, the ability to determine whether patient tumors contain metastatic subpopulations is still lacking. Recently, organelle morphology and function has been used as a direct readout of the functional phenotypic state of an individual cancer cell. We propose to use the spatial context of organelles, specifically their subcellular location and inter-organelle relationships (topology), to classify novel and distinct metastatic cancer cell subpopulations. We developed an Organelle Topology-based Cell Classification Pipeline (OTCCP) to quantify, for the first time, the topological features of subcellular organelles, defined as the distance between each organelle object and all its neighbors within a cell. Under RFA-CA-21-013 (Development of Innovative Informatics Methods and Algorithms for Cancer Research and Management), we will adapt or develop Machine learning and Deep Learning methodologies to accelerate and automate OTCCP-based organelle- based topology cancer cell classification to identify subpopulations of metastatic cells within heterogeneous primary tumors with potential diagnostic and prognostic value. This approach will also have major impact as a discovery tool to advance our understanding of cancer cell biology on a subcellular level.
摘要

项目成果

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Margarida Barroso其他文献

Margarida Barroso的其他文献

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{{ truncateString('Margarida Barroso', 18)}}的其他基金

AI enhanced lifetime-based mesoscopic in vivo imaging of tissue molecular heterogeneity
人工智能增强了基于寿命的组织分子异质性细观体内成像
  • 批准号:
    10585510
  • 财政年份:
    2023
  • 资助金额:
    $ 8.15万
  • 项目类别:
Artificial intelligence enhanced cancer cell classification based organelle morphology and topology
人工智能增强基于细胞器形态和拓扑的癌细胞分类
  • 批准号:
    10528867
  • 财政年份:
    2022
  • 资助金额:
    $ 8.15万
  • 项目类别:
In vivo Macroscopic Fluorescence Lifetime Molecular Optical Imaging
体内宏观荧光寿命分子光学成像
  • 批准号:
    10474962
  • 财政年份:
    2020
  • 资助金额:
    $ 8.15万
  • 项目类别:
Endosome-mitochondria interactions in breast cancer cells
乳腺癌细胞中内体-线粒体相互作用
  • 批准号:
    10328547
  • 财政年份:
    2020
  • 资助金额:
    $ 8.15万
  • 项目类别:
In vivo Macroscopic Fluorescence Lifetime Molecular Optical Imaging
体内宏观荧光寿命分子光学成像
  • 批准号:
    10277118
  • 财政年份:
    2020
  • 资助金额:
    $ 8.15万
  • 项目类别:
In vivo Macroscopic Fluorescence Lifetime Molecular Optical Imaging
体内宏观荧光寿命分子光学成像
  • 批准号:
    10621919
  • 财政年份:
    2020
  • 资助金额:
    $ 8.15万
  • 项目类别:
Endosome-mitochondria interactions in breast cancer cells
乳腺癌细胞中内体-线粒体相互作用
  • 批准号:
    10547808
  • 财政年份:
    2020
  • 资助金额:
    $ 8.15万
  • 项目类别:
Endosome-mitochondria interactions in breast cancer cells
乳腺癌细胞中内体-线粒体相互作用
  • 批准号:
    10083202
  • 财政年份:
    2020
  • 资助金额:
    $ 8.15万
  • 项目类别:
Photon-counting X-ray and Optical Tomography for Preclinical Cancer Research
用于临床前癌症研究的光子计数 X 射线和光学断层扫描
  • 批准号:
    10247629
  • 财政年份:
    2019
  • 资助金额:
    $ 8.15万
  • 项目类别:
Photon-counting X-ray and Optical Tomography for Preclinical Cancer Research
用于临床前癌症研究的光子计数 X 射线和光学断层扫描
  • 批准号:
    10017171
  • 财政年份:
    2019
  • 资助金额:
    $ 8.15万
  • 项目类别:

相似国自然基金

益气活血法对4T1乳腺癌细胞肺转移及SDF-1/CXCR4生物轴的干预作用
  • 批准号:
    81503517
  • 批准年份:
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  • 批准号:
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  • 批准年份:
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  • 资助金额:
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  • 项目类别:
    青年科学基金项目

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Differential proteome analysis identifies TGF-beta related pro-metastatic proteins in a 4T1 murine breast cancer model
差异蛋白质组分析鉴定 4T1 小鼠乳腺癌模型中的 TGF-β 相关促转移蛋白
  • 批准号:
    25871241
  • 财政年份:
    2013
  • 资助金额:
    $ 8.15万
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
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