Improving breast cancer risk assessment and prevention in Asian American women

改善亚裔美国女性的乳腺癌风险评估和预防

• 批准号: 10879960
• 负责人: Sora P Tanjasiri
• 金额: $ 19.35万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-23 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10879960
• 关键词: Address; Administrator; Advisory Committees; Advocate; African American; Applications Grants; Asian; Asian Americans; Basic Science; Biological Sciences; Biotechnology; Breast Cancer Risk Factor; California; Cancer Center; Cancer health equity; Collaborations; Communities; Comprehensive Cancer Center; County; DNA sequencing; Data; Development; Education; Education and Outreach; Educational Curriculum; Environment; Epidemiology; Ethnic Population; Evaluation; Faculty; Family; Fostering; Funding; Future; Genetic; Genomics; Goals; Grant; Health Disparities Research; Institution; Institutionalization; Joints; Knowledge; Length; Lesbian Gay Bisexual Transgender Queer; Low income; Malignant Neoplasms; Malignant neoplasm of ovary; Oranges; Pilot Projects; Population; Preparation; Prevention; Principal Investigator; Recommendation; Records; Research; Research Personnel; Research Project Grants; Research Training; Risk Assessment; Sampling; Scientist; Seasons; Students; System; Talents; Teacher Professional Development; Training; Training Activity; Training Programs; Training and Education; Underrepresented Students; Underserved Population; United States National Institutes of Health; Universities; Woman; anticancer research; cancer health disparity; cancer research center director; community based participatory research; community engagement; disability; education research; epidemiology study; ethnic diversity; experience; graduate student; improved; innovation; institutional capacity; lipidomics; meetings; member; minority health; minority health disparity; mortality; outreach; professor; programs; student training; transcriptome sequencing; transcriptomics; treatment pattern; triple-negative invasive breast carcinoma; tumor; undergraduate student; underrepresented minority student

CSUF/UCI-CFCCC Cancer Health Equity Research Partnership (CHERP) Overall Component: Abstract California State University, Fullerton (CSUF) is an institution serving underserved populations and underrepresented students (ISUPS), and the University of California, Irvine Chao Family Comprehensive Cancer Center (UCI-CFCCC) is an NCI-designated comprehensive cancer center. Together, we plan to establish a collaborative partnership to develop pilot research projects between faculty members at CSUF and UCI-CFCCC that will generate preliminary data for R01 or other competitively funded grant applications, and educate undergraduates (at CSUF) and master's students (at CSUF and UCI) in cancer health disparities research. The Partnership plans to fund five pilot projects, and educate a total of 38 students during the length of the proposed grant period. The overall specific aims of this new cancer-specific partnership are to: plan, implement and evaluate a highly integrated and interactive cancer health disparities partnership between CSUF and UCI- CFCCC; conduct pilot cancer health disparities research projects involving at least one investigator at each institution that advance knowledge regarding cancer health disparities, leading to the submission of competitive grant applications by NIH/NCI and other federal/non-federal agencies; and provide cancer research education to underrepresented undergraduate and graduate students to increase their understanding of cancer health disparities, leading to a larger pool of highly talented future scientists from diverse backgrounds. To accomplish this we will undertake a set of activities organized under four components. The Administrative Core will be responsible for the overall administrative and fiscal aspects of all P20 activities, and will include the Executive Committee and Internal Advisory Committee. Activities will be implemented in three stages: initial planning, implementation, and evaluation. The evaluation effort will be spearheaded by an external evaluator with expertise in multi-component center reviews. The two pilot research projects each focus on a cancer health disparity: the first is a basic science study that will conduct lipidomic profiling, and DNA and RNA sequencing of tumor/NAT paired samples to optimize sample preparation and detect genetic/genomic and transcriptomic differences that are related to African American triple negative breast cancer risk. The second is an epidemiological study that will examine Asian sub-ethnic group differences in ovarian cancer mortality and treatment patterns. The long term goals of this collaborative partnership are to diversity the cancer research workforce and ultimately increase our scientific impact to address the cancer health disparity needs in Orange County, California.

CSUF/UCI-CFCCC癌症健康公平研究伙伴关系（CHERP） 总体组成部分：摘要 加州州立大学，富勒顿（CSUF）是一个机构服务不足的人口， 代表性不足的学生（IUPS）和加州大学欧文赵家庭综合癌症 中心（UCI-CFCCC）是一个NCI指定的综合性癌症中心。我们计划共同建立一个 合作伙伴关系，以开发CSUF和UCI-CFCCC教师之间的试点研究项目 这将为R 01或其他有竞争力的资助申请生成初步数据， 本科生（在CSUF）和硕士生（在CSUF和UCI）在癌症健康差异研究。的 伙伴关系计划资助五个试点项目，并在拟议的时间内教育总共38名学生。 补助期。这一新的针对癌症的伙伴关系的总体具体目标是： 评估CSUF和UCI之间高度整合和互动的癌症健康差异伙伴关系， CFCCC;开展试点癌症健康差异研究项目，每个项目至少有一名研究人员参与 机构，先进的知识，关于癌症的健康差距，导致提交竞争 NIH/NCI和其他联邦/非联邦机构的拨款申请;并提供癌症研究教育 向代表性不足的本科生和研究生提供帮助，以增加他们对癌症健康的了解 差异，导致来自不同背景的高素质未来科学家的更大的池。 为此，我们将开展一系列活动，分为四个部分。行政 核心将负责所有P20活动的总体行政和财政方面，并将包括 执行委员会和内部咨询委员会。活动将分三个阶段实施： 规划、实施和评估。评价工作将由一名外部评价员带头进行 具有多组分中心审查的专业知识。这两个试点研究项目分别侧重于癌症健康 差异：第一个是基础科学研究，将进行脂质组学分析，DNA和RNA测序， 肿瘤/NAT配对样本，以优化样本制备并检测遗传/基因组和转录组 与非洲裔美国人三阴性乳腺癌风险相关的差异。第二个是 一项流行病学研究，将检查亚洲亚种族群体在卵巢癌死亡率方面的差异， 治疗模式。这种合作伙伴关系的长期目标是使癌症研究多样化 劳动力，并最终提高我们的科学影响力，以解决橙子癌症健康差异的需求 加州县。