Influences of Early and Later Life Events on Cognition and All-Cause Dementia in China

中国早年和晚年生活事件对认知和全因痴呆的影响

基本信息

批准号：
10879934
负责人：
JOHN A STRAUSS
金额：
$ 53.34万
依托单位：
UNIVERSITY OF SOUTHERN CALIFORNIA
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-09-15 至 2025-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10879934
关键词：
Adult Affect Alzheimer&apos s Disease Alzheimer&apos s disease related dementia Birth Childhood China Chinese Chinese population Cognition Cognitive Communities Country Data Dementia Diabetes Mellitus Earthquakes Economics Education Elderly Employee Environmental Risk Factor Event Extended Family Family Famines Friends Funding Geography Goals Government Officials Growth Health Health Status Health and Retirement Study Household Impaired cognition Incidence Income India Individual Institution Interview Life Life Cycle Stages Life Expectancy Link Literature Longitudinal Studies Measures Mental Depression Modeling Natural Disasters Obesity Older Population Outcome Paper Persons Physical environment Politics Population Population Study Prevalence Publishing Recording of previous events Research Resources Respondent Retirement Risk Risk Factors Sampling Smoking Social isolation Socioeconomic Status Son Stressful Event Surveys Visual impairment Woman Women Status cognitive ability cohort cost dementia risk design drinking farmer follow-up gender difference hearing impairment human old age (65+)improved life history lifestyle factors low income country men middle age novel physical inactivity preference protective factors trend

项目摘要

Project Summary Rising life expectancy is contributing to rapid increases in the size of the older population and is expected to lead to a sharp rise in Alzheimer’s disease and Alzheimer’s disease related dementias from about 47 million people worldwide today, to potentially more than 140 million in 2050. However, recent population studies have found that the incidence of Alzheimer’s disease and Alzheimer’s disease related dementias is lower than that indicated by previous projections in some countries, but greater in others. Lifestyle factors as well as environmental factors might reduce or increase an individual’s risk of developing dementia. We propose to advance our understanding of protective and risk factors for late-life cognitive decline and Alzheimer’s disease and Alzheimer’s disease-related dementias (hereafter referred to as dementia) in China. We propose a novel life-course model of risk factors, building on the recently proposed model by the Lancet commission, which links dementia risk to early and mid-life factors, within the context of historical, institutional, and physical environments, including obesity, diabetes hearing loss, visual impairment, smoking, drinking, depression, physical inactivity, social isolation, and socioeconomic status. Specifically, this project aims to further study early and mid-life personal, family, community, and external factors that may contribute to late-life cognition and dementia risk using new, retrospective life-history interview data in China.

项目摘要预期寿命的提高正在导致老年人口的大小迅速增加，并且是预计将导致阿尔茨海默氏病和阿尔茨海默氏病有关当今全球约4700万人的痴呆症，可能超过1.4亿 2050年。但是，最近的人口研究发现阿尔茨海默氏病的事件和阿尔茨海默氏病有关的痴呆症低于先前项目所指出的痴呆症在某些国家，但在其他国家中更大。生活方式因素和环境因素可能会减少或增加个人患痴呆症的风险。我们建议进步我们对晚年认知下降和阿尔茨海默氏症的保护性和危险因素的理解疾病和阿尔茨海默氏病与疾病有关的痴呆症（以下称为痴呆症）。我们提出了一种新颖的危险因素的生活课程模型柳叶刀委员会将痴呆症风险与早期和中期因素联系起来历史，机构和物理环境的背景，包括肥胖，糖尿病听力损失，视觉障碍，吸烟，饮酒，抑郁，身体不活动，社交孤立和社会经济地位。特别是，该项目旨在进一步研究早期和中年的个人，家庭，社区，以及可能有助于使用新的认知和痴呆风险的外部因素回顾性的生活历史访谈数据。