Influences of Early and Later Life Events on Cognition and All-Cause Dementia in China

项目摘要 预期寿命的增长正在推动老年人口规模的快速增长，并正在 预计将导致阿尔茨海默病和阿尔茨海默病相关疾病急剧上升 痴呆症从目前全球约4700万人，到2019年可能超过1.4亿人 2050年。然而，最近的人口研究发现，阿尔茨海默病的发病率 与阿尔茨海默病相关的痴呆症比以前的预测要低 在一些国家，但在其他国家更大。生活方式因素和环境因素 可能会降低或增加个人患痴呆症的风险。我们建议推进 我们对老年认知功能减退和阿尔茨海默病的保护性因素和危险因素的理解 中国与阿尔茨海默病相关痴呆(以下简称痴呆症) 在最近提出的风险因素生命周期模型的基础上，我们提出了一个新的风险因素生命周期模型 柳叶刀委员会将痴呆症风险与早年和中年因素联系起来，在 历史、体制和自然环境的背景，包括肥胖、糖尿病 听力损失、视力障碍、吸烟、饮酒、抑郁、缺乏运动、社交 与世隔绝，以及社会经济地位。 具体地说，这个项目旨在进一步研究早中年的个人、家庭、社区、 以及可能导致晚年认知和痴呆症风险的外部因素， 回顾中国的生活史访谈资料。

Project Summary Rising life expectancy is contributing to rapid increases in the size of the older population and is expected to lead to a sharp rise in Alzheimer’s disease and Alzheimer’s disease related dementias from about 47 million people worldwide today, to potentially more than 140 million in 2050. However, recent population studies have found that the incidence of Alzheimer’s disease and Alzheimer’s disease related dementias is lower than that indicated by previous projections in some countries, but greater in others. Lifestyle factors as well as environmental factors might reduce or increase an individual’s risk of developing dementia. We propose to advance our understanding of protective and risk factors for late-life cognitive decline and Alzheimer’s disease and Alzheimer’s disease-related dementias (hereafter referred to as dementia) in China. We propose a novel life-course model of risk factors, building on the recently proposed model by the Lancet commission, which links dementia risk to early and mid-life factors, within the context of historical, institutional, and physical environments, including obesity, diabetes hearing loss, visual impairment, smoking, drinking, depression, physical inactivity, social isolation, and socioeconomic status. Specifically, this project aims to further study early and mid-life personal, family, community, and external factors that may contribute to late-life cognition and dementia risk using new, retrospective life-history interview data in China.