Great Plains IDeA-CTR

总体项目摘要 大平原是一个广阔的农村地区，有零星的城市发展。地理和社会隔离- 再加上农村和服务不足的城市地区缺乏获得初级和专门保健的机会， 是我们最脆弱人群的特征GP IDEA-CTR网络成立于2016年， 满足这些迫切的需求。总部设在联合国监测委员会，伙伴机构遍布内布拉斯加州和 因此，我们建立了一个强大的，网络化的研究基础设施，以发展和指导我们的CTR调查， 促进资源共享，推进CTR调查人员和社区成员之间的合作。 我们利用与国家CTR、CTSA和其他国家组织的关系， 制定CTR的实践和策略。这些成就促进了团队的网络文化 科学，并加强了我们成功竞争研究奖项的能力和翻译能力， 基础和临床研究，以促进社区卫生需求。根据PAR-20-175， 具有竞争力的续订应用程序巩固了我们的GP IDEA-CTR收益并提高了PAR 进一步发展关键的基础设施和人力资源，以满足社区康复需求和健康 通过满足4个具体目标来应对我们网络中的挑战：1）进一步发展基础设施，服务， 资源和社区关系需要扩大资助CTR; 2）扩大专业发展 与试点项目计划（PPP）合作开展活动，培养成功的CTR调查员骨干; 3)加强内布拉斯加州和大平原地区的合作伙伴关系 和堪萨斯）;以及4）创造一个促进创新的多学科，多地点和跨实体的环境 (e.g.,公共-私营）伙伴关系、IDEA（国家CTR、COBRE、INBRE、ISPCTN、SEPA）和其他国家 (e.g., CTSA）合作。我们在强有力的领导下共同努力，在合作、支持、 以及来自NIGMS、由强大的CTR专家组成的内部和外部咨询委员会以及社区的建议 咨询委员会。GP-IDEA CTR增强了内布拉斯加大学系统所有机构的合作伙伴关系 (UNMC，UNO，UNL和UNK）和Boys Town国家研究医院，扩大了我们的机构合作伙伴 网络，包括克雷顿大学，儿童医院和医疗中心，和奥马哈退伍军人管理局。我们 继续发展以社区为基础的实践研究网络。我们打造一个新的 与DaCCoTA CTR的关系，以加强CTR与达科他州机构的联系。我们继续 通过我们的核心（行政，专业发展， 生物统计学，社区参与，生物医学信息学，跟踪和评估）和PPP，由 我们从第一个供资周期汲取的经验教训。我们加强了我们跨越筒仓的主题重点 团队科学，并继续推进创新和创业精神，以促进整个 CTR频谱和建设能力，将社区相关的CTR想法推向市场。

Overall Project Summary The Great Plains is a vast, rural region with pockets of urban development. Geographic and social isolation— combined with lack of access to primary and specialized care in both rural and underserved urban areas— characterize some of our most vulnerable populations. The GP IDeA-CTR network was established in 2016 to address these pressing needs. Headquartered at UNMC with partner institutions across Nebraska and the Dakotas, we built a robust, networked research infrastructure to develop and guide our CTR investigators, promote resource sharing, and advance collaborations among CTR investigators and community members. We leveraged relationships with national CTRs, CTSAs, and other national organizations to share best practices and strategies for developing CTR. These accomplishments advanced a network culture of team science and strengthened our ability to compete successfully for research awards and capacity to translate basic and clinical research to advance community health needs. In response to PAR-20-175, this competitive renewal application consolidates our GP IDeA-CTR gains and advances the PAR’s objectives to further develop key infrastructure and human resources to meet CTR needs and health challenges across our network by meeting 4 specific aims: 1) Further develop the infrastructure, services, resources, and community relationships needed to expand funded CTR; 2) Expand professional development activities in concert with the Pilot Projects Program (PPP) to cultivate a cadre of successful CTR investigators; 3) Strengthen collaborative partnerships across Nebraska and regional Great Plains IDeA states (the Dakotas and Kansas); and 4) Create an environment that fosters innovative multidisciplinary, multisite, and cross-entity (e.g., public-private) partnerships, IDeA (national CTR, COBRE, INBRE, ISPCTN, SEPA) and other national (e.g., CTSAs) collaborations. We do so working together under strong leadership, with collaboration, support, and advice from NIGMS, Internal and External Advisory Committees of strong CTR experts, and a Community Advisory Board. The GP-IDeA CTR enhances partnerships across all Nebraska University System Institutions (UNMC, UNO, UNL, and UNK) and Boys Town National Research Hospital, expands our institutional partner network to include Creighton University, Children’s Hospital and Medical Center, and the Omaha VA. We continue development of a community-anchored Practice-Based Research Network. We forge a new relationship with the DaCCoTA CTR to strengthen CTR connections with Dakota institutions. We continue to advance services and sustainable resources through our Cores (Administrative, Professional Development, Biostatistics, Community Engagement, Biomedical Informatics, Tracking & Evaluation) and PPP, informed by our experience and lessons learned from the first funding cycle. We sharpen our silo-spanning thematic focus on team science and continue to advance innovation and entrepreneurship to catalyze movement across the CTR spectrum and build capacity to bring community-relevant CTR ideas to the marketplace.