Great Plains IDeA-CTR

整体项目总结 大平原是一个广阔的农村地区，有零星的城市发展。地理和社会上的隔绝- 再加上在农村和服务不足的城市地区缺乏初级和专科护理-- 描述我们一些最脆弱的人群。全科医生IDEA-CTR网络成立于2016年，旨在 解决这些紧迫的需求。总部设在UNMC，与内布拉斯加州和 在达科他州，我们建立了一个强大的、联网的研究基础设施来开发和指导我们的CTR调查人员， 促进资源共享，促进CTR调查人员和社区成员之间的合作。 我们利用与国家CTR、CTSA和其他国家组织的关系来分享最佳 发展CTR的实践和战略。这些成就促进了团队的网络文化 科学，增强了我们成功竞争研究奖项和翻译能力的能力 促进社区卫生需求的基础和临床研究。为了回应PAR-20-175，这 竞争性续订申请巩固了我们的全科医生理念-CTR获益并提升了标准杆 目标：进一步发展关键基础设施和人力资源，以满足CTR需求和卫生 通过实现4个具体目标来应对我们网络中的挑战：1)进一步发展基础设施、服务、 扩大资助的CTR所需的资源和社区关系；2)扩大专业发展 与试点项目方案(PPP)协调开展的活动，以培养一支成功的CTR调查员队伍； 3)加强内布拉斯加州和大平原地区各州(达科他州)的合作伙伴关系 和堪萨斯州)；以及4)创造一个环境，促进创新的多学科、多地点和跨实体 (例如，公私)伙伴关系、IDEA(国家CTR、科布雷、INBRE、ISPCTN、SEPA)和其他国家 (例如，CTSA)协作。我们在强有力的领导下，在合作、支持、 和来自NIGMS、由强大的CTR专家组成的内部和外部咨询委员会以及社区的建议 顾问委员会。GP-IDEA CTR加强了所有内布拉斯加州大学系统机构的合作伙伴关系 (UNMC、UNO、UNL和UNK)和Boys town国立研究医院，扩大了我们的机构合作伙伴 网络包括克雷顿大学、儿童医院和医学中心以及奥马哈退伍军人管理局。我们 继续发展以社区为基础、以实践为基础的研究网络。我们打造了一个新的 与DaCCoTA CTR的关系，以加强CTR与达科他州各机构的联系。我们将继续 通过我们的核心提升服务和可持续资源(行政、专业发展、 生物统计、社区参与、生物医学信息学、跟踪和评估)和购买力平价，由 我们从第一个供资周期中吸取的经验和教训。我们突出了我们跨越竖井的主题重点 致力于团队科学，并继续推进创新和创业，以促进 CTR频谱和建设能力，将与社区相关的CTR创意推向市场。

Overall Project Summary The Great Plains is a vast, rural region with pockets of urban development. Geographic and social isolation— combined with lack of access to primary and specialized care in both rural and underserved urban areas— characterize some of our most vulnerable populations. The GP IDeA-CTR network was established in 2016 to address these pressing needs. Headquartered at UNMC with partner institutions across Nebraska and the Dakotas, we built a robust, networked research infrastructure to develop and guide our CTR investigators, promote resource sharing, and advance collaborations among CTR investigators and community members. We leveraged relationships with national CTRs, CTSAs, and other national organizations to share best practices and strategies for developing CTR. These accomplishments advanced a network culture of team science and strengthened our ability to compete successfully for research awards and capacity to translate basic and clinical research to advance community health needs. In response to PAR-20-175, this competitive renewal application consolidates our GP IDeA-CTR gains and advances the PAR’s objectives to further develop key infrastructure and human resources to meet CTR needs and health challenges across our network by meeting 4 specific aims: 1) Further develop the infrastructure, services, resources, and community relationships needed to expand funded CTR; 2) Expand professional development activities in concert with the Pilot Projects Program (PPP) to cultivate a cadre of successful CTR investigators; 3) Strengthen collaborative partnerships across Nebraska and regional Great Plains IDeA states (the Dakotas and Kansas); and 4) Create an environment that fosters innovative multidisciplinary, multisite, and cross-entity (e.g., public-private) partnerships, IDeA (national CTR, COBRE, INBRE, ISPCTN, SEPA) and other national (e.g., CTSAs) collaborations. We do so working together under strong leadership, with collaboration, support, and advice from NIGMS, Internal and External Advisory Committees of strong CTR experts, and a Community Advisory Board. The GP-IDeA CTR enhances partnerships across all Nebraska University System Institutions (UNMC, UNO, UNL, and UNK) and Boys Town National Research Hospital, expands our institutional partner network to include Creighton University, Children’s Hospital and Medical Center, and the Omaha VA. We continue development of a community-anchored Practice-Based Research Network. We forge a new relationship with the DaCCoTA CTR to strengthen CTR connections with Dakota institutions. We continue to advance services and sustainable resources through our Cores (Administrative, Professional Development, Biostatistics, Community Engagement, Biomedical Informatics, Tracking & Evaluation) and PPP, informed by our experience and lessons learned from the first funding cycle. We sharpen our silo-spanning thematic focus on team science and continue to advance innovation and entrepreneurship to catalyze movement across the CTR spectrum and build capacity to bring community-relevant CTR ideas to the marketplace.