Stroke Central Atlantic Network for Research (SCANR)

中风中央大西洋研究网络 (Scanr)

• 批准号: 10850004
• 负责人: BARBARA S BREGMAN
• 金额: $ 3.73万
• 依托单位: MEDSTAR HEALTH RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-01 至 2023-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10850004
• 关键词: Acute; Adult; African American; Arteries; Baltimore; Biological Markers; Black race; Blood Vessels; Brain; Cerebral Amyloid Angiopathy; Cerebrum; Cervical; Child; Childhood; Childhood stroke; Clinical; Disparity; Dissection; Doctor of Philosophy; Eligibility Determination; Enrollment; Extramural Activities; Fellowship Program; Funding; Genetic; Health Disparities Research; Historically Black Colleges and Universities; Hospitals; Image; Institution; Intervention; Leadership; Link; Magnetic Resonance Imaging; Maryland; Medical center; Mentored Clinical Scientist Development Program; Mentorship; Mid-Atlantic Region; Multimodal Imaging; National Institute of Neurological Disorders and Stroke; Neurologist; Neurology; Patient Recruitments; Patients; Persons; Phase; Phenotype; Play; Positioning Attribute; Prevention; Prevention trial; Process; Productivity; Registries; Rehabilitation therapy; Reporting; Research; Research Institute; Research Personnel; Research Training; Residencies; Robotics; Role; Scientist; Site; Stroke; Stroke Belt; StrokeNet trials; Training; Translating; Translational Research; Underserved Population; Universities; Venous Thrombosis; Virginia; Washington; acute stroke; career; career development; cerebrovascular; experience; innovation; microbiome research; multidisciplinary; multimodality; multiple omics; neurological rehabilitation; news; novel; participant retention; patient population; programs; recruit; rehabilitation research; research and development; rural setting; screening; stroke incidence; stroke patient; stroke rehabilitation; stroke trials; treatment trial; urban setting

FROM ORIGINAL PROPOSAL: SCANR, the Stroke Central Atlantic Network for Research is based in the Mid- Atlantic region and headquartered in Washington, DC, and Charlottesville, VA. SCANR is located on the edge of the Stroke Belt, and both DC and Baltimore have high stroke incidence. SCANR includes four Carnegie Research 1 universities (Georgetown and George Washington Universities; the Universities of Virginia and Maryland), two CTSAs, a translational research institute (THRIV), a US News & World Report National Honor Roll Hospital (Children's National Medical Center), the largest hospital in DC (MedStar Washington Hospital Center), two Historically Black Universities (Howard University and University of DC) and the NINDS Intramural Stroke Program. SCANR sites evaluated over 4100 acute strokes in 2016, >50% were Black/African American. Our NINDS-funded trial recruitment is excellent, screening all eligible patients for and enrolling in StrokeNet trials: DEFUSE 3, MISTIE 3, HiDef, Rhapsody, SHINE, POINT, and MR WITNESS, along with additional NINDS-funded trials. SCANR also includes the National Coordinating Center for SHINE (UVa, Johnston-PI), and the CREST-2 registry and imaging core (UMB, Lal). SCANR 2.0 continues to have all of the excellent qualities that made SCANR 1.0 a strong contender for StrokeNet selection: pediatric stroke and stroke rehabilitation, patient populations and innovative recruitment practices for health disparities research, and the link to the NINDS Intramural Stroke Program. These strengths will stand out with the pediatric, rehab, and pediatric rehab trials in the StrokeNet pipeline. SCANR 2.0 includes UVa as a high-performing site for acute treatment and prevention trials. UVa also provides expertise in biomarkers, genetics, and prehospital research. The addition of UVa and UMB made SCANR a truly regional Coordinating Center. SCANR 2.0 research expertise includes multimodal imaging, microbiomics, multi-omics, Neurorehabilitation trials, brain stimulation, and robotics. We are well positioned to translate early phase NINDS intramural studies into the extramural setting. We have a track record of recruiting substantial numbers of specific cerebrovascular phenotypes (cervical artery dissection, cerebral venous thrombosis, cerebral amyloid angiopathy, etc.). Our consortium of academic rehab hospitals is outstanding. We currently have four trial proposals submitted to StrokeNet in varying stages of the process. Our existing Participant Recruitment and Retention Core (PRRO Core) has played a leadership role in the StrokeNet network. SCANR investigators serve on national StrokeNet steering committees and cores. Our StrokeNet fellows have diverse clinical backgrounds (2 vascular neurologists, 1 PT PhD, 1 OT) and subsequently, they successfully compete for external funding (TL-2, KL-2, AHA). They have opportunities for outstanding research training and mentorship across our Mid- Atlantic institutions, preparing them for productive research careers. SCANR investigators recently successfully established a novel national K12 program for rehabilitation research. We currently have 5 relevant fellowship programs and three adult neurology residencies at the SCANR 2.0 sites. This training joins strong multidisciplinary clinical and research expertise in stroke with much experience in research and career development of clinician scientists.

来自原始提案：SCANR，中风中心大西洋研究网络位于美国中部， 大西洋地区，总部设在华盛顿，哥伦比亚特区和夏洛茨维尔，弗吉尼亚州。SCANR位于 中风带，华盛顿特区和巴尔的摩的中风发病率都很高。SCANR包括四个卡内基研究1 大学（乔治敦大学和乔治华盛顿大学;弗吉尼亚大学和马里兰州大学）、两所CTSA、一所 翻译研究所（THRIV），美国新闻与世界报道国家荣誉名册医院（儿童国家 医学中心），华盛顿特区最大的医院（MedStar华盛顿医院中心），两所历史上的黑人大学 （霍华德大学和华盛顿大学）和NINDS校内卒中项目。 SCANR网站在2016年评估了超过4100例急性卒中，>50%是黑人/非裔美国人。NINDS资助的试验 招募非常出色，筛选所有符合条件的患者并招募入StrokeNet试验：DEFUSE 3，MISTIE 3，HiDef， Rhapsody，SHINE，POINT和MR WITNESS，沿着其他NINDS资助的试验。SCANR还包括 SHINE国家协调中心（UVa，Johnston-PI）和CREST-2登记和成像核心（UMB，Lal）。 SCANR2.0继续拥有使SCANR1.0成为StrokeNet强有力竞争者的所有优秀品质 选择：儿科卒中和卒中康复、患者人群和创新的健康招募实践 差异研究，以及与NINDS校内中风项目的联系。这些优势将与 在StrokeNet管道中进行儿科、康复和儿科康复试验。SCANR 2.0包括UVa作为高性能站点 用于急性治疗和预防试验。UVa还提供生物标志物，遗传学和院前研究方面的专业知识。 UVa和UMB的加入使SCANR成为真正的区域协调中心。 SCANR 2.0研究专长包括多模态成像、微生物组学、多组学、神经康复试验、脑 刺激和机器人。我们有能力将早期的NINDS内部研究转化为外部研究。 设置.我们有招募大量特定脑血管表型（颈动脉 夹层、脑静脉血栓形成、脑淀粉样血管病等）。我们的学术康复医院联盟是 非常出色。我们目前有四个试验提案提交给中风网络在不同阶段的过程。我们现有 参与者招募和保留核心（PRRO核心）在中风网络中发挥了领导作用。 SCANR调查人员在国家StrokeNet指导委员会和核心中任职。我们的StrokeNet研究员有各种各样的 临床背景（2名血管神经学家，1名PT博士，1名OT），随后，他们成功地竞争了外部 供资（TL-2、KL-2、AHA）。他们有机会在我们的中， 大西洋机构，为他们的生产性研究生涯做好准备。SCANR调查人员最近成功地 建立了一个新的国家K12康复研究计划。我们目前有5个相关的奖学金计划 和SCANR 2.0站点的三个成人神经病学住院医师。这项培训加入了强大的多学科临床和 中风研究专业知识，临床科学家的研究和职业发展经验丰富。