Neurorehabilitation and Restorative Neuroscience Network

神经康复和恢复神经科学网络

• 批准号: 9405068
• 负责人: BARBARA S BREGMAN
• 金额: $ 77.22万
• 依托单位: GEORGETOWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-01 至 2022-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9405068
• 关键词: Basic Science; Benchmarking; Chronic; Clinical; Clinical Research; Clinical Trials; Complex; Development Plans; Discipline; Disease; Doctor of Philosophy; Faculty; Funding; General Hospitals; Geography; Grant; Health Occupations; Health system; Hospitals; Individual; Institutes; Interdisciplinary Study; Leadership; Manuscripts; Maryland; Massachusetts; Mentored Clinical Scientist Development Program; Mentors; Mentorship; Mission; Nervous System Trauma; Nervous system structure; Neurorehabilitation; Neurosciences; Outcome; Patients; Phase; Population; Positioning Attribute; Productivity; Recovery; Recovery of Function; Recruitment Activity; Rehabilitation therapy; Research; Research Personnel; Research Training; SECTM1 gene; Science; Site; Technology; TimeLine; Training; Translating; Travel; United States National Institutes of Health; Universities; Vocational Guidance; Writing; base; career development; coping; disability; educational atmosphere; effective intervention; health care delivery; nervous system disorder; new technology; programs; translational neuroscience

The paucity of NIH-funded Phase III rehabilitation clinical trials is prima facie evidence that, despite multiple cycles of taxpayer funding, the incumbent K12 programs have fallen short in their mission of translating science into treatments for patients. We emphasize the K12 RFA’s first Background sentence: “Despite the increasing population of individuals coping with chronic disabilities at various levels, the field of medical rehabilitation has not responded sufficiently to the need for research to validate approaches, optimize treatments, and incorporate new technologies and opportunities.” Existing programs are inwardly focused and mired in supporting historical academic and clinical silos. They do not prioritize the research needs of patients or the training needed to develop investigators equipped to overcome complex disabling disorders. We intend a different approach. First, we will include all clinical disciplines, and simply recruit the best scholars. Second, we will focus on a single group of disorders: disabling chronic neurological disorders. Thus, we target a multilevel scientific approach (from molecules to outcomes), all directed at the problem of nervous system recovery and not a clinical credential. Third, we will blend the best of old and new by pairing excellent and traditional university-based training settings with more contemporary excellent healthcare delivery training settings based in nonprofit health systems. Fourth, we have assembled a leadership team composed of successful translational neuroscience/neurorehabilitation investigators with a track record of interdisciplinary research training. These individuals are national leaders, and each has a wide network for recruiting scholars and mentors nationally. Finally, we increase efficiency by reducing travel barriers with a geographically compact network and maximize trainee productivity by including an executive coaching program. Alexander Dromerick, MD and Barbara Bregman, PT, PhD are Program Directors. The coordinating site is Georgetown University and affiliated National Rehabilitation Hospital. Other primary sites: John Hopkins /Kennedy Krieger Institute (Bastian), Harvard (Schlaug), Massachusetts General Hospital Institute of Health Professions (Connor), Massachusetts Institute of Technology (Krebs), University of Maryland/Kernan (Wittenberg), and Cornell/Burke Rehabilitation Hospital (Ratan). We will provide the strongest possible interdisciplinary mentorship and training for the early career development of these K12 scholars from all neurorehabilitation disciplines in an educational environment that promotes strong interactions between basic and clinical research to develop effective interventions to promote functional recovery after neurological injuries. We will support 4 faculty scholars yearly,(2-3 years each); they will remain engaged in the K12 program activities for 5 years as they transition to independent faculty positions. Together with their local primary mentor, each scholar develops an individual career development plan that includes research training, coursework, manuscript and grant writing support with specific timelines and benchmarks for progress.

NIH资助的III期康复临床试验的缺乏是初步证据，尽管 纳税人的资金多个周期，现任K12计划已经在他们的使命不足， 将科学转化为对病人的治疗。我们强调K12 RFA的第一个背景句子： “尽管越来越多的人在不同程度上应对慢性残疾， 医疗康复还没有充分响应研究的需要，以验证方法，优化， 治疗，并纳入新技术和机会。现有的项目都是向内聚焦的， 陷入了支持历史学术和临床筒仓的困境。他们不优先考虑患者的研究需求 或者培养有能力克服复杂残疾障碍的调查人员所需的培训。 我们打算采取不同的方法。首先，我们将包括所有临床学科，并简单地招募最好的 学者其次，我们将集中在一组疾病：致残性慢性神经系统疾病。因此，在本发明中， 我们的目标是一个多层次的科学方法（从分子到结果），所有针对神经问题， 系统恢复而不是临床证书。第三，我们将通过优秀的配对， 和传统的大学培训环境，以及更现代的优秀医疗保健提供培训 非营利卫生系统的设置。第四，我们组建了一个领导班子， 成功的翻译神经科学/神经康复研究者，具有跨学科的跟踪记录 研究训练。这些人都是国家领导人，每个人都有一个广泛的网络来招募学者 全国的导师。最后，我们通过减少地理上的旅行障碍来提高效率， 紧凑的网络和最大限度地提高学员的生产力，包括执行教练计划。 亚历山大Dromerick，医学博士和芭芭拉Bregman，PT，博士是项目总监。协调 地点是乔治敦大学和附属国家康复医院。其他主要研究中心：约翰霍普金斯 /肯尼迪克里格研究所（巴斯蒂安）、哈佛（施劳格）、马萨诸塞州总医院卫生研究所 塞申斯（康纳）、马萨诸塞州理工学院（克雷布斯）、马里兰州大学/克南 （Wittenberg）和Cornell/Burke康复医院（Ratan）。我们会提供最强的 跨学科的指导和培训，这些K12学者的早期职业发展，从所有 在教育环境中的神经康复学科，促进基本之间的强有力的互动 和临床研究，以开发有效的干预措施，促进神经功能恢复后， 受伤我们将每年支持4名教师学者，（每人2-3年）;他们将继续参与K12 项目活动5年，因为他们过渡到独立的教师职位。与当地的 主要导师，每个学者制定一个个人的职业发展计划，其中包括研究培训， 课程作业、手稿和赠款写作支持，有具体的时间表和进展基准。