FFT BASED IMAGES WITH DIFFUSING LIGHT WAVES

基于 FFT 的漫射光波图像

• 批准号: 2377292
• 负责人: ARJUN G. YODH
• 金额: $ 23.31万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-30 至 2000-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2377292
• 关键词: biomedical equipment development; breast neoplasm /cancer diagnosis; diagnosis design /evaluation; human data; image enhancement; interferometry; noninvasive diagnosis; optics; phantom model; spectrometry; tomography; visible light

DESCRIPTION (Adapted from Applicant's Abstract): The applicants proposed to improve the tumor diagnostic capabilities of optical spectroscopy and imaging based on diffusing near infrared light. The proposed work aims to develop and assess the utility of a new tomographic image reconstruction scheme that may be applicable, for example, to tumor detection and characterization within the human breast. The theoretical approaches will be tested experimentally using existing photon migration instrumentation and computer codes primarily developed for compressed breast and box geometries. The detrimental effects of boundaries on image fidelity will be mitigated using a novel theoretical approach that incorporates experimental measurements of the photon density waves on the boundary. Finally, a realistic prototype parallel plate instrument will be built and tested in phantoms. If successful, the applicants anticipate combining the optimal device with existing instrumentation for diffuse-optical / MRI breast diagnostics at their institution. In this scenario, the applicants plan to apply for additional funding to support these clinical studies. The primary benefit derivable from the proposed research will be improved image fidelity and reconstruction speed, which in turn, will enable clinicians to fully exploit the new spectroscopic and scattering contrast mechanisms available with the optical method for increased tumor sensitivity and specificity. The scheme is a near-field Fast Fourier Transform (FFT) approach that affords a rapid imaging of absorption and scattering variations that are either intrinsic properties of the tissue or are selectively induced by administration of optical contrast agents. The method offers the possibility of Projection (2-D) images and full three- dimensional reconstructions. The projection images may be combined with complementary localizing techniques to deduce optical properties of tissue without full volume reconstruction. The method is new to the field; it differs from least squares techniques such as ART and SIRT in that it is fast and predominately non-iterative; its computational complexity scales with voxel number as N2lnN rather than N3. It also offers a well defined prescription for handling boundary effects. If successful, it is anticipated that the anatomical information generated by the devices based on these theories will be useful for improving our ability to specify the nature of tumors inside breast in a non-invasive, non-ionizing and cost effective way.

描述（改编自申请人摘要）：申请人提出， 提高光谱学的肿瘤诊断能力， 基于漫射近红外光的成像。 拟议的工作旨在 开发和评估新的断层图像重建的实用性 可以应用于例如肿瘤检测的方案 人体乳房内的特征。 理论方法将 使用现有的光子迁移仪器进行实验测试， 主要为压缩乳房和盒子几何形状开发的计算机代码。 边界对图像保真度的不利影响将得到缓解 使用一种新的理论方法， 测量边界上的光子密度波。 最后 一个现实的原型平行板仪器将建立和测试， 幻影 如果成功，申请人预计将结合最佳的 用于漫射光学/ MRI乳腺成像的现有器械 诊断在他们的机构。 在这种情况下，申请人计划 申请额外资金支持这些临床研究。 主 从拟议的研究中可以得到的好处是提高了图像保真度 和重建速度，这反过来将使临床医生能够充分 利用新的光谱和散射对比机制 用光学方法提高肿瘤的灵敏度和特异性。 该方案是近场快速傅立叶变换（FFT）方法， 提供了吸收和散射变化的快速成像， 或者是组织的固有特性，或者是由 施用光学造影剂。 该方法提供了 投影（2-D）图像和全三维图像的可能性 重建。 投影图像可以与互补图像组合。 用于推断组织的光学性质的定位技术， 体积重建 该方法是该领域的新方法;它不同于 最小二乘技术，如ART和SIRT，因为它是快速的， 主要是非迭代的;其计算复杂度与体素成比例 编号为N2 lnN而不是N3。 它还提供了一个定义明确的处方 处理边界效应。 如果成功，预计 由基于这些理论的装置产生的解剖信息将 有助于提高我们确定肿瘤内部性质的能力， 以非侵入性、非电离和成本有效的方式治疗乳腺癌。