NOVEL FAST TIMING SILICON DRIFT PHOTODETECTORS FOR PET

适用于宠物的新型快速定时硅漂移光电探测器

• 批准号: 2423010
• 负责人: BRADLEY E PATT
• 金额: $ 10万
• 依托单位: PHOTON IMAGING, INC.
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-08-01 至 1998-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2423010
• 关键词: biomedical equipment development; breast neoplasm /cancer diagnosis; clinical biomedical equipment; image processing; photomultiplier; positron emission tomography; radiation detector; silicon; solid state

The goal of this proposal is to develop a novel detector/imaging device for positron emission imaging. A basic detector module will consist of an LSO crystal cut into parallet-piped elements and coupled to a matched Silicon Drift Photodetector (SDP) array whose elements provide excellent energy and timing resolution. The proposed system is intended to eliminate the need for photomultiplier tubes and allow for intergration of electronics with the detector leading to lower cost PET systems. We plan to develop an imaging system utilizing a pair of 4 inch diameter LSO/SDP modules, each consisting of 40 x 40 detector pixels, optimized for use with FDG for detection of breast cancer. A coincidence imaging device optimized for breast imaging has the potential of improving on the sensitivity (x20), count rate and spatial resolution versus a full PET system. The development of the 2-detector module breast imager will allow basic detector development to occur along with the development of a needed product to improve cancer detection. Improved sensitivity will result in better image quality, reduced imaging time or smaller injected doses. The proposed detector development program has specific goals divided into two technical phases. Phase 1: Design optimized detector structure leading to the targeted performance for electronic noise, quantum efficiency, narrow transit time of electrons; (2) Fabricate prototype 8 x 8 SDP array; (3) Evaluate parameters of the devise to measure the potential for success for long term aims of the project. Phase 2: (1) Develop final SDP array structures with integrated input transistor-preamplifier; (2) Develop housing, specialized processing and display electronics and reconstruction software; and (3) Construct and evaluate prototype detector system under simulated clinical conditions before deployment for testing at the UCLA Iris Cantor Breast Center. PROPOSED COMMERCIAL APPLICATION In the third phase we will commercialize single and multiple detector modules based upon the Phase 1 and Phase 2 efforts, as well as a complete dedicated system for clinical use in positron emission imaging for detection of breast cancer. These new detectors will lead to lower cost PET detector systems by utilizing a new SDP which needs only low cost silicon planar processing and allows integration of electronics with the detector. There are large needs and potential for commercial uses for such PMT replacements for PET.

该提案的目标是开发一种新型探测器/成像 正电子发射成像装置。 基本探测器模块将 由切割成平行管元件的 LSO 晶体组成， 耦合至匹配的硅漂移光电探测器 (SDP) 阵列 其元件提供出色的能量和时间分辨率。 拟议的系统旨在消除对 光电倍增管并允许电子器件集成 该探测器可降低 PET 系统的成本。 我们计划 利用一对 4 英寸直径开发成像系统 LSO/SDP 模块，每个模块由 40 x 40 探测器像素组成， 优化用于与 FDG 一起检测乳腺癌。 一个 针对乳腺成像优化的符合成像设备具有 提高灵敏度 (x20)、计数率和 空间分辨率与完整 PET 系统的比较。 的发展 2 探测器模块乳房成像仪将允许基本探测器 发展随着所需的发展而发生 改善癌症检测的产品。 提高灵敏度将 获得更好的图像质量、缩短或更短的成像时间 注射剂量。 拟议的探测器开发计划 具体目标分为两个技术阶段。 第一阶段：设计 优化的探测器结构可实现目标性能 对于电子噪声、量子效率、窄渡越时间 电子； (2) 制作原型8 x 8 SDP阵列； (3) 评估 衡量成功潜力的设备参数 该项目的长期目标。 第 2 阶段：(1) 制定最终的 SDP 具有集成输入晶体管前置放大器的阵列结构； (2) 开发外壳、专业加工和显示电子产品 重建软件； (3) 构建和评估原型 之前模拟临床条件下的检测器系统 部署在加州大学洛杉矶分校艾里斯坎托乳腺中心进行测试。 拟议的商业应用 在第三阶段，我们将把单个和多个商业化 基于第一阶段和第二阶段工作的探测器模块，如 以及用于正电子临床使用的完整专用系统 用于检测乳腺癌的发射成像。 这些新 探测器将通过利用 一种新的SDP，只需要低成本的硅平面处理和 允许电子设备与检测器集成。 有大 这种 PMT 的商业用途的需求和潜力 PET 的替代品。