NOVEL FAST TIMING SILICON DRIFT PHOTODETECTORS FOR PET

这项提议的目标是开发一种新的探测器/成像 用于正电子发射成像的装置。一个基本的探测器模块将 由切割成平行管状元件的LSO晶体和 耦合到匹配的硅漂移光电探测器(SDP)阵列 其元件提供出色的能量和定时分辨率。 拟议的系统旨在消除对 光电倍增管，并允许电子器件与 该探测器可降低PET系统的成本。我们计划 开发一种利用一对4英寸直径的成像系统 LSO/SDP模块，每个模块由40×40个探测器像素组成， 经过优化，可与FDG一起用于检测乳腺癌。一个 为乳房成像优化的符合成像设备具有 提高灵敏度(X20)、计数率和 空间分辨率与全PET系统的对比。的发展。 双探测器模块乳房成像仪将允许基本探测器 发展是伴随着所需要的 提高癌症检测水平的产品。提高敏感度将 提供更好的图像质量、更短的成像时间或更小 注射剂量。拟议的探测器开发计划具有 具体目标分为两个技术阶段。阶段1：设计 优化的探测器结构，实现目标性能 对于电子噪声、量子效率、窄渡越时间 电子；(2)制作8x8SDP阵列样机；(3)评估 衡量成功潜力的设计参数 该项目的长期目标。阶段2：(1)制定最终SDP 集成输入晶体管前置放大器的阵列结构；(2) 发展住房、专业加工和显示电子产品和 重建软件；以及(3)构建和评估原型 模拟临床条件下的检测系统 部署在加州大学洛杉矶分校虹膜康托乳房中心进行测试。 建议的商业应用 在第三阶段，我们将把单机和多机商业化 基于阶段1和阶段2的探测器模块，如 以及一套完整的正电子临床专用系统 用于乳腺癌检测的发射成像。这些新的 探测器将导致更低成本的PET探测器系统 一种只需要低成本硅平面加工的新型SDP 允许将电子设备与探测器集成。有很大的 这种PMT的商业用途的需求和潜力 PET的替代品。

The goal of this proposal is to develop a novel detector/imaging device for positron emission imaging. A basic detector module will consist of an LSO crystal cut into parallet-piped elements and coupled to a matched Silicon Drift Photodetector (SDP) array whose elements provide excellent energy and timing resolution. The proposed system is intended to eliminate the need for photomultiplier tubes and allow for intergration of electronics with the detector leading to lower cost PET systems. We plan to develop an imaging system utilizing a pair of 4 inch diameter LSO/SDP modules, each consisting of 40 x 40 detector pixels, optimized for use with FDG for detection of breast cancer. A coincidence imaging device optimized for breast imaging has the potential of improving on the sensitivity (x20), count rate and spatial resolution versus a full PET system. The development of the 2-detector module breast imager will allow basic detector development to occur along with the development of a needed product to improve cancer detection. Improved sensitivity will result in better image quality, reduced imaging time or smaller injected doses. The proposed detector development program has specific goals divided into two technical phases. Phase 1: Design optimized detector structure leading to the targeted performance for electronic noise, quantum efficiency, narrow transit time of electrons; (2) Fabricate prototype 8 x 8 SDP array; (3) Evaluate parameters of the devise to measure the potential for success for long term aims of the project. Phase 2: (1) Develop final SDP array structures with integrated input transistor-preamplifier; (2) Develop housing, specialized processing and display electronics and reconstruction software; and (3) Construct and evaluate prototype detector system under simulated clinical conditions before deployment for testing at the UCLA Iris Cantor Breast Center. PROPOSED COMMERCIAL APPLICATION In the third phase we will commercialize single and multiple detector modules based upon the Phase 1 and Phase 2 efforts, as well as a complete dedicated system for clinical use in positron emission imaging for detection of breast cancer. These new detectors will lead to lower cost PET detector systems by utilizing a new SDP which needs only low cost silicon planar processing and allows integration of electronics with the detector. There are large needs and potential for commercial uses for such PMT replacements for PET.