Development of Diet Methodology for N-nitroso Compounds

N-亚硝基化合物饮食方法学的发展

• 批准号: 6695748
• 负责人: JANICE E STUFF
• 金额: $ 7.29万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-01 至 2005-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6695748
• 关键词: brain neoplasms; clinical research; computer program /software; computer system design /evaluation; human subject; information systems; method development; neoplasm /cancer epidemiology; nitroso compounds; nutrient intake activity; nutrition related neoplasm /cancer; nutrition related tag; questionnaires; statistics /biometry

DESCRIPTION (provided by applicant): Brain cancer is a leading cause of cancer death and it is a deadly disease with a poorly understood etiology. The most consistent risk factor is ionizing radiation, and the genetic and environmental risk factors are unknown. It has been suggested that N-nitroso compounds or foods high in them may be a major contributor to cancer risk. The proposed research focuses on the association between dietary N-nitroso intake and brain cancer. The hypothesis that N-nitroso compounds are associated with human brain cancer is supported by several lines of evidence. First, animal experiments have shown the N-nitroso compounds to be the most broad acting and the most potent group of carcinogens. Second, mechanisms how N-nitroso compounds promote DNA damage and lead to carcinogenesis have been described. Finally, some, but not all epidemiological studies evaluating the role of N-nitroso compounds have shown a positive association or increased risk of stomach and upper gastro-intestinal tract cancers, colorectal cancer, and brain cancer. However, most dietary epidemiological studies have measured intakes of N-nitroso compounds poorly, used surrogate or incomplete measures, and had low statistical power. Therefore, a validated instrument for the dietary assessment for N-nitroso intake using appropriate nutritional, biometric, and epidemiological techniques is needed. The goal of this developmental project is to use quantitative techniques to develop a valid, reliable, and sensitive tool for assessing N-nitroso dietary intake in adults, and then retest the association between N-nitroso intake and brain cancer. Ultimately the methodology will support subsequent investigations in the rapidly developing area of genetic and molecular epidemiology, and help understand genetic and dietary interactions of N-nitroso compounds in the development of brain and other cancers.

描述（由申请人提供）： 脑癌是癌症死亡的主要原因，它是一种病因学知之甚少的致命疾病。最一致的危险因素是电离辐射，遗传和环境危险因素尚不清楚。有人认为，N-亚硝基化合物或富含此类化合物的食物可能是导致癌症风险的主要因素。拟议的研究重点是膳食 N-亚硝基摄入量与脑癌之间的关联。 N-亚硝基化合物与人类脑癌相关的假设得到了多项证据的支持。首先，动物实验表明，N-亚硝基化合物是作用最广泛、最强效的一组致癌物。其次，描述了 N-亚硝基化合物促进 DNA 损伤并导致癌变的机制。最后，一些（但不是所有）评估 N-亚硝基化合物作用的流行病学研究表明，与胃癌和上胃肠道癌、结直肠癌和脑癌呈正相关或增加风险。然而，大多数饮食流行病学研究对 N-亚硝基化合物摄入量的测量效果不佳，使用替代或不完整的测量方法，并且统计功效较低。因此，需要使用适当的营养、生物测定和流行病学技术来使用经过验证的仪器来评估 N-亚硝基摄入量。该开发项目的目标是利用定量技术开发一种有效、可靠且灵敏的工具来评估成人 N-亚硝基饮食摄入量，然后重新测试 N-亚硝基摄入量与脑癌之间的关联。最终，该方法将支持快速发展的遗传和分子流行病学领域的后续研究，并有助于了解 N-亚硝基化合物在脑癌和其他癌症发展中的遗传和饮食相互作用。