Dietary Intake Patterns of N-Nitroso Compounds

N-亚硝基化合物的膳食摄入模式

• 批准号: 7665286
• 负责人: JANICE E STUFF
• 金额: $ 6.95万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-04 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7665286
• 关键词: Address; Adult; African American; Age; Antioxidants; Ascorbic Acid; Automobile Driving; Body mass index; Cancer Etiology; Case-Control Studies; Categories; Cessation of life; Chemopreventive Agent; Clinical Data; Colorectal; Data Set; Databases; Diet; Dietary Practices; Dietary intake; Epidemiologic Studies; Epidemiology; Ethnic Origin; Ethnic group; Folate; Food; Food Patterns; Frequencies; Gender; Goals; Hispanic Americans; Hour; Income; Individual; Intake; Intestines; Investigation; Knowledge; Leisure Activities; Link; Lung; Malignant Neoplasms; Malignant neoplasm of brain; Measures; Meat; Methodology; Methods; Morbidity - disease rate; National Health and Nutrition Examination Survey; Nitroso Compounds; Nutrient; Pancreas; Participant; Pattern; Persons; Physical activity; Population; Poverty; Prevention strategy; Primary Cancer Prevention; Process; Public Health; Questionnaires; Race; Recommendation; Reporting; Resources; Role; Sampling; Source; Stomach; Subgroup; Surveys; Testing; Vitamin A; Vitamin E; age group; cancer health disparity; cancer risk; design; improved; indexing; information gathering; innovation; lifestyle factors; novel; novel strategies; programs; racial and ethnic

DESCRIPTION (provided by applicant): This application is a formative step towards assessing dietary intake of N-Nitroso compounds in populations to inform subsequent epidemiological investigations and dietary methodology. Lung, stomach, upper gastro-intestinal tract, pancreatic, colorectal, and brain cancers are leading causes of cancer morbidity and death. Mutagenic/carcinogenic N-nitroso compounds in foods have been described in the etiology of these cancers. In order to make a major impact on these cancers, a better understanding of novel dietary preventive strategies is essential. For example processed and preserved meats have a positive association with increased risk of cancer. However, investigations pursing estimates of N-nitroso intakes have been impeded by the lack of a database that summarized N-nitroso food values, and the food patterns driving their intake is unknown across the US population, among subgroups who are at risk for cancer. Lack of such knowledge is an important problem, because, without it, we are unable to fully identify the carcinogenic role of dietary N-nitroso compounds and to make public health recommendations to reduce their intake. To fulfill the gap, we recently developed a dietary database of N-nitroso compounds. The current project will take advantage of the existing N-Nitroso database and the National Health and Nutrition Examination Survey (NHANES) 2003-2004 to validate and measure N-Nitroso compound intake in the total population and by subgroups (race/ethnicity, age group, BMI, income, and leisure activity). We will further explore the interaction of N-nitroso compounds and antioxidants, and the major food contributors of N-nitroso compounds according to population subgroups. The central hypothesis is that high dietary intake of N- Nitroso compounds alone and in interaction with other nutrients vary by subgroups. Using NHANES 2003-2004 dietary, demographic, and other variables in 5280 adults, our existing database of N-nitroso compound values will be linked to foods reported in two 24-hour dietary recalls per sample person. The main effects of the variables and their interactions will be examined by using the new NCI Method of estimating dietary intakes of compounds and foods with programs adapted for NHANES datasets. The proposed study is innovative because it will result in adapting dietary methodology for N-nitroso estimates, and combine existing resources of a N-nitroso dietary database, together with the dietary, demographic, and clinical data from a large national dataset. Information gathered from this study will be valuable in generating novel dietary related hypotheses for cancer case-control studies, and to identify foods and questions for improving dietary methodology specific for N-Nitroso assessment.

描述（由申请人提供）：本申请是评估人群中N-亚硝基化合物膳食摄入量的形成性步骤，为后续流行病学调查和膳食方法提供信息。肺癌、胃癌、上胃肠道癌、胰腺癌、结肠直肠癌和脑癌是癌症发病率和死亡率的主要原因。食物中的致突变/致癌N-亚硝基化合物已被描述为这些癌症的病因。为了对这些癌症产生重大影响，更好地了解新的饮食预防策略至关重要。例如，加工和腌制的肉类与癌症风险增加有积极的联系。然而，由于缺乏总结N-亚硝基食物价值的数据库，因此对N-亚硝基摄入量估计的调查受到阻碍，并且在美国人群中，在有癌症风险的亚组中，推动其摄入量的食物模式是未知的。缺乏这方面的知识是一个重要问题，因为如果没有这方面的知识，我们就无法充分确定饮食中N-亚硝基化合物的致癌作用，也无法提出减少其摄入量的公共卫生建议。为了填补这一差距，我们最近开发了一个N-亚硝基化合物的膳食数据库。目前的项目将利用现有的N-亚硝基数据库和2003-2004年国家健康和营养调查（NHANES），验证和测量总人口和亚组（种族/民族，年龄组，BMI，收入和休闲活动）的N-亚硝基化合物摄入量。我们将进一步探讨N-亚硝基化合物和抗氧化剂的相互作用，以及根据人口分组，N-亚硝基化合物的主要食物来源。中心假设是，高膳食摄入量的N-亚硝基化合物单独和与其他营养素的相互作用，不同的亚组。使用NHANES 2003-2004饮食，人口统计学和其他变量在5280名成年人，我们现有的数据库的N-亚硝基化合物的值将被链接到两个24小时的饮食召回每个样本人报告的食物。变量的主要影响及其相互作用将通过使用新的NCI方法来评估化合物和食物的膳食摄入量，并采用适用于NHANES数据集的程序进行检查。拟议的研究是创新的，因为它将导致适应N-亚硝基估计的饮食方法，并结合联合收割机现有的N-亚硝基饮食数据库的资源，以及来自大型国家数据集的饮食，人口统计和临床数据。从这项研究中收集的信息将是有价值的，在癌症病例对照研究中产生新的饮食相关的假设，并确定食品和问题，以改善饮食方法的具体N-亚硝基评估。