Dietary Intake Patterns of N-Nitroso Compounds

N-亚硝基化合物的膳食摄入模式

• 批准号: 7858412
• 负责人: JANICE E STUFF
• 金额: $ 6.95万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-04 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7858412
• 关键词: Address; Adult; African American; Age; Antioxidants; Ascorbic Acid; Automobile Driving; Body mass index; Cancer Etiology; Case-Control Studies; Categories; Cessation of life; Chemopreventive Agent; Clinical Data; Colorectal; Data Set; Databases; Diet; Dietary Practices; Dietary intake; Epidemiologic Studies; Epidemiology; Ethnic Origin; Ethnic group; Folate; Food; Food Patterns; Frequencies; Gender; Goals; Hispanic Americans; Hour; Income; Individual; Intake; Intestines; Investigation; Knowledge; Leisure Activities; Link; Lung; Malignant Neoplasms; Malignant neoplasm of brain; Measures; Meat; Methodology; Methods; Morbidity - disease rate; National Health and Nutrition Examination Survey; Nitroso Compounds; Nutrient; Pancreas; Participant; Pattern; Persons; Physical activity; Population; Poverty; Prevention strategy; Primary Cancer Prevention; Process; Public Health; Questionnaires; Race; Recommendation; Reporting; Resources; Role; Sampling; Source; Stomach; Subgroup; Surveys; Testing; Vitamin A; Vitamin E; age group; cancer health disparity; cancer risk; design; improved; indexing; information gathering; innovation; lifestyle factors; novel; novel strategies; programs; racial and ethnic

DESCRIPTION (provided by applicant): This application is a formative step towards assessing dietary intake of N-Nitroso compounds in populations to inform subsequent epidemiological investigations and dietary methodology. Lung, stomach, upper gastro-intestinal tract, pancreatic, colorectal, and brain cancers are leading causes of cancer morbidity and death. Mutagenic/carcinogenic N-nitroso compounds in foods have been described in the etiology of these cancers. In order to make a major impact on these cancers, a better understanding of novel dietary preventive strategies is essential. For example processed and preserved meats have a positive association with increased risk of cancer. However, investigations pursing estimates of N-nitroso intakes have been impeded by the lack of a database that summarized N-nitroso food values, and the food patterns driving their intake is unknown across the US population, among subgroups who are at risk for cancer. Lack of such knowledge is an important problem, because, without it, we are unable to fully identify the carcinogenic role of dietary N-nitroso compounds and to make public health recommendations to reduce their intake. To fulfill the gap, we recently developed a dietary database of N-nitroso compounds. The current project will take advantage of the existing N-Nitroso database and the National Health and Nutrition Examination Survey (NHANES) 2003-2004 to validate and measure N-Nitroso compound intake in the total population and by subgroups (race/ethnicity, age group, BMI, income, and leisure activity). We will further explore the interaction of N-nitroso compounds and antioxidants, and the major food contributors of N-nitroso compounds according to population subgroups. The central hypothesis is that high dietary intake of N- Nitroso compounds alone and in interaction with other nutrients vary by subgroups. Using NHANES 2003-2004 dietary, demographic, and other variables in 5280 adults, our existing database of N-nitroso compound values will be linked to foods reported in two 24-hour dietary recalls per sample person. The main effects of the variables and their interactions will be examined by using the new NCI Method of estimating dietary intakes of compounds and foods with programs adapted for NHANES datasets. The proposed study is innovative because it will result in adapting dietary methodology for N-nitroso estimates, and combine existing resources of a N-nitroso dietary database, together with the dietary, demographic, and clinical data from a large national dataset. Information gathered from this study will be valuable in generating novel dietary related hypotheses for cancer case-control studies, and to identify foods and questions for improving dietary methodology specific for N-Nitroso assessment.

描述(由申请人提供)：本申请是评估人群中N-亚硝基化合物饮食摄入量的形成步骤，为后续的流行病学调查和饮食方法提供信息。肺癌、胃癌、上消化道、胰腺癌、结直肠癌和脑癌是癌症发病率和死亡率的主要原因。食品中的致突变/致癌N-亚硝基化合物在这些癌症的病因学中已有描述。为了对这些癌症产生重大影响，更好地理解新的饮食预防策略是至关重要的。例如，加工和腌制肉类与癌症风险的增加呈正相关。然而，由于缺乏总结N-亚硝基食物价值的数据库，以及在美国人口中，导致N-亚硝基摄入量的食物模式未知，在有癌症风险的亚群中，寻求N-亚硝基摄入量估计值的调查一直受到阻碍。缺乏这种知识是一个重要的问题，因为如果没有这种知识，我们就无法充分确定饮食中N-亚硝基化合物的致癌作用，并提出减少其摄入量的公共卫生建议。为了填补这一空白，我们最近开发了N-亚硝基化合物的饮食数据库。目前的项目将利用现有的N-亚硝基数据库和2003-2004年国家健康和营养检查调查(NHANES)来验证和测量总人口和亚硝基化合物的摄入量(种族/族裔、年龄组、体重指数、收入和休闲活动)。我们将根据种群亚群进一步探讨N-亚硝基化合物与抗氧化剂的相互作用以及N-亚硝基化合物的主要食物贡献者。中心假设是，N-亚硝基化合物的高膳食摄入量以及与其他营养素的相互作用因不同的亚组而异。使用NHANES 2003-2004年在5280名成年人中的饮食、人口统计和其他变量，我们现有的N-亚硝基化合物值数据库将与每个样本每人两次24小时饮食召回中报告的食物联系起来。这些变量及其相互作用的主要影响将通过使用新的NCI方法进行检验，该方法通过适用于NHANES数据集的程序来估计化合物和食物的饮食摄入量。这项拟议的研究具有创新性，因为它将导致对N-亚硝基估算的膳食方法进行调整，并将N-亚硝基膳食数据库的现有资源与来自大型国家数据集的膳食、人口统计学和临床数据相结合。这项研究收集的信息将有助于为癌症病例对照研究产生新的饮食相关假说，并为改进N-亚硝基评估的饮食方法确定食物和问题。