Alcoholism, Sleep and the Brain
酗酒、睡眠和大脑
基本信息
- 批准号:6597432
- 负责人:
- 金额:$ 49.24万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2003
- 资助国家:美国
- 起止时间:2003-06-01 至 2008-05-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
DESCRIPTION (provided by applicant): Acute and chronic alcohol consumption causes sleep disturbances, which may never resolve and may be a key factor in alcoholism relapse. Alcohol-related sleep deficits also become more pronounced with advancing age. The most consistently reported finding of altered sleep in alcoholics is a reduction in spontaneously occurring slow wave sleep (SWS), defined by the presence of delta EEG activity. Further, alcoholics with reduced baseline SWS have an increased likelihood of relapse.
External stimulation during sleep can elicit K-complexes, which when averaged produce a large N550 component thought to have the same generator as SWS delta activity. Given the potential value of sleep markers in predicting relapse, it would be advantageous to employ a probe of the sleeping nervous system that can be under experimenter control rather than one that relies on the traditional observation of spontaneous sleep physiological indices.
We have demonstrated that sleep-evoked N550 component amplitudes are smaller and K-complexes are produced on a smaller number of trials in elderly than young controls. Our preliminary study indicates that alcoholics have even smaller N550 than would be expected for their age. A candidate generator of the K-complex and N550 is frontal cortical gray matter, which is especially reduced in older alcoholics. Sex differences in brain structure and electrophysiological indices of sleep also occur in alcoholism and aging, and objective study of them may further contribute to our understanding of relevant mechanisms of alcoholism-related sleep disturbance. We propose to test the following hypotheses:
Hypothesis 1: Recently detoxified, chronic alcoholics will have smaller N550 amplitudes, lower evoked K-complex proportions, lower SWS levels and delta EEG power compared to sex- and age-matched controls.
Hypothesis 2: Low evoked K-complex production rates, small N550 amplitude, low SWS levels and delta EEG power will be associated with small prefrontal gray matter volume.
Hypothesis 3: Alcoholic men will have greater sleep abnormalities than alcoholic women.
Hypothesis 4: Small amplitude, production rate and power of sleep electrophysiological variables in recently detoxified alcoholics will predict early relapse.
描述(由申请人提供):急性和慢性饮酒导致睡眠障碍,这可能永远不会解决,可能是酗酒复发的关键因素。与酒精相关的睡眠不足也随着年龄的增长而变得更加明显。酗酒者睡眠改变的最一致报道是自发发生的慢波睡眠(SWS)减少,定义为δ EEG活动的存在。此外,基线SWS降低的酗酒者复发的可能性增加。
睡眠期间的外部刺激可以引起K复合物,当平均时产生大的N550组分,其被认为具有与SWS δ活动相同的发生器。考虑到睡眠标记物在预测复发中的潜在价值,采用可以在实验者控制下的睡眠神经系统的探针而不是依赖于自发睡眠生理指标的传统观察的探针将是有利的。
我们已经证明,睡眠诱发的N550成分的振幅较小,K-复合物产生的试验在老年人比年轻的控制数量较少。我们的初步研究表明,酗酒者的N550甚至比他们这个年龄的预期还要小。K复合体和N550的候选生成器是额叶皮质灰质,这在老年酗酒者中尤其减少。酒精中毒和衰老也存在脑结构和睡眠电生理指标的性别差异,对其进行客观研究有助于我们进一步了解酒精中毒相关睡眠障碍的相关机制。我们建议检验以下假设:
假设1:最近脱毒,慢性酗酒者将有较小的N550振幅,较低的诱发K复合体的比例,较低的SWS水平和δ EEG功率相比,性别和年龄匹配的控制。
假设二:低诱发K复合波产生率、小N550振幅、低SWS水平和δ EEG功率将与小的前额叶灰质体积相关。
假设3:酗酒的男性比酗酒的女性有更大的睡眠异常。
假设四:小振幅,生产率和功率的睡眠电生理变量在最近脱毒酗酒者将预测早期复发。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Ian Michael Colrain其他文献
Ian Michael Colrain的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Ian Michael Colrain', 18)}}的其他基金
Sleep EEG and MRI Markers of Brain Recovery with Alcohol Abstinence
戒酒后大脑恢复的睡眠脑电图和 MRI 标记
- 批准号:
8177112 - 财政年份:2011
- 资助金额:
$ 49.24万 - 项目类别:
Sleep EEG and MRI Markers of Brain Recovery with Alcohol Abstinence
戒酒后大脑恢复的睡眠脑电图和 MRI 标记
- 批准号:
8308351 - 财政年份:2011
- 资助金额:
$ 49.24万 - 项目类别:
相似国自然基金
基于DNA甲基化交互网络的癌症hallmark挖掘及其在癌症转移biomarker筛选中的应用
- 批准号:61602201
- 批准年份:2016
- 资助金额:20.0 万元
- 项目类别:青年科学基金项目
血清miRNAs成为一种新的biomarker在PD诊断中的价值和LRRK2基因调控的机制研究
- 批准号:81170309
- 批准年份:2011
- 资助金额:50.0 万元
- 项目类别:面上项目
非小细胞肺癌Biomarker的Imaging MS研究新方法
- 批准号:30672394
- 批准年份:2006
- 资助金额:30.0 万元
- 项目类别:面上项目
相似海外基金
酸化ストレス応答アポトーシス誘導蛋白のUCに対する新規Biomarker探索と治療への展開
寻找治疗 UC 的氧化应激反应性凋亡诱导蛋白的新生物标志物并开发治疗方法
- 批准号:
24K11919 - 财政年份:2024
- 资助金额:
$ 49.24万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
肝内胆管癌新規Biomarkerの同定及び癌周囲間質を標的とした新規治療開発
鉴定肝内胆管癌的新型生物标志物并开发针对癌周基质的新疗法
- 批准号:
24K19350 - 财政年份:2024
- 资助金额:
$ 49.24万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
収縮能が保たれた心不全の機械学習分類とmicroRNAなどのbiomarkerの探索
机器学习对具有保留收缩性的心力衰竭进行分类并搜索 microRNA 等生物标志物
- 批准号:
24K19007 - 财政年份:2024
- 资助金额:
$ 49.24万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
Development of a predictive biomarker for Parkinson's disease
帕金森病预测生物标志物的开发
- 批准号:
MR/Y019415/1 - 财政年份:2024
- 资助金额:
$ 49.24万 - 项目类别:
Research Grant
Sleep and circadian dysfunction in ageing and neurodegeneration: a life course and biomarker study of the British 1946 birth cohort.
衰老和神经退行性疾病中的睡眠和昼夜节律功能障碍:对英国 1946 年出生队列的生命历程和生物标志物研究。
- 批准号:
MR/Y009452/1 - 财政年份:2024
- 资助金额:
$ 49.24万 - 项目类别:
Fellowship
Biomarker-Based Platform for Early Diagnosis of Chronic Liver Disease to Enable Personalized Therapy (LIVERAIM)
基于生物标志物的慢性肝病早期诊断平台,以实现个性化治疗(LIVERAIM)
- 批准号:
10087822 - 财政年份:2024
- 资助金额:
$ 49.24万 - 项目类别:
EU-Funded
Enhanced stratification of COPD patients via integration of a digitally enabled biomarker Point-of-Care test within a Remote Patient Monitoring tool
通过在远程患者监测工具中集成数字化生物标志物即时检测,增强 COPD 患者的分层
- 批准号:
10098600 - 财政年份:2024
- 资助金额:
$ 49.24万 - 项目类别:
Collaborative R&D
QuBIE: Quantitative Biomarker Identification for Non-Endoscopic Prediction and Monitoring of Treatment Response in Eosinophilic Oesophagitis
QuBIE:用于非内镜预测和监测嗜酸性食管炎治疗反应的定量生物标志物鉴定
- 批准号:
10083253 - 财政年份:2024
- 资助金额:
$ 49.24万 - 项目类别:
Collaborative R&D
膵癌腫瘍内線維化に着目した術前化学療法効果予測に関する画像biomarkerの確立
建立预测胰腺癌瘤内纤维化术前化疗效果的影像生物标志物
- 批准号:
24K18824 - 财政年份:2024
- 资助金额:
$ 49.24万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
Multi-modal non-invasive biomarker screening for high-risk undiagnosed liver disease
针对高危未确诊肝病的多模式非侵入性生物标志物筛查
- 批准号:
10073169 - 财政年份:2023
- 资助金额:
$ 49.24万 - 项目类别:
Collaborative R&D