Alcohol, Sleep and Brain Development

酒精、睡眠和大脑发育

• 批准号: 7502689
• 负责人: Ian Michael Colrain
• 金额: $ 48.18万
• 依托单位: SRI INTERNATIONAL
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-30 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7502689
• 关键词: Adolescence; Adolescent; Adolescent Behavior; Adolescent Development; Adult; Affect; Alcohol abuse; Alcohol consumption; Alcohol or Other Drugs use; Alcoholism; Alcohols; Behavior; Behavioral; Brain; Brain imaging; Child; Chronic; Cognition; Cognitive; Condition; Corpus Callosum; Development; Diffusion Magnetic Resonance Imaging; Disruption; Drug usage; Elderly; Electroencephalography; Emotional; Emotions; Equilibrium; Family history of; Fire - disasters; Frequencies; Gender; Gray unit of radiation dose; Growth; Growth and Development function; Health; Hippocampus (Brain); Hormonal; Human; Impact evaluation; Investigation; Lead; Learning; Longitudinal Studies; Magnetic Resonance Imaging; Measures; Memory; Nervous system structure; Neuraxis; Neurologic; Neurons; Numbers; Pathway interactions; Pattern; Physiological Adaptation; Physiology; Process; Production; REM Sleep; Rehabilitation therapy; Reliance; Resolution; Risk; Role; Sampling; Series; Sexual Maturation; Sleep; Slow-Wave Sleep; Somatotropin; Structure; Time; alcohol exposure; boys; cognitive function; cohort; design; drinking; emotional adjustment; frontal lobe; frontal lobe function; girls; gray matter; insight; myelination; neurophysiology; neurotoxicity; prospective; response; size; white matter

DESCRIPTION (provided by applicant): This proposal is in response to an RFA to evaluate the feasibility of conducting longitudinal assessments of the impact of alcohol exposure on adolescent brain development. Alcohol abuse among children and adolescents at a time when their brains continue to develop is a significant health risk, and the deleterious chronic effects on a developing nervous system are underappreciated. The proposed studies bring together sensitive, safe and noninvasive approaches to characterize brain neurophysiology and structural integrity during normal adolescence and to estimate the effect of alcohol abuse on the developing brain. Unique to this proposal are the use of classical sleep physiology and evoked EEG delta activity as probes of the developing nervous system and their integration with assessment of brain macro- and micro-structural integrity. Elucidation of the insidious central nervous system effects of alcohol abuse among adolescents will lead to better understanding of alcohol neurotoxicity may provide demonstrable evidence to influence adolescent behavior and may provide insights into compensatory and rehabilitative strategies for treating impaired cognitive, emotional and regulatory behavioral development. The proposal has four specific aims: Aim 1. Establish two small, ethically balanced samples from large cohorts of boys and girls, to demonstrate the capacity to evaluate alcohol and other substance use in these cohorts, and follow each for one year. The first will consist of 20 non-drinking 6th graders. The second will consist of 10 non-drinking and 10 drinking 9th graders. Aim 2. By comparing within and between cohorts, evaluate how advancing age and pubertal hormonal development are correlated with functional brain measures of delta activity, N550 amplitude, frontalization of delta and N550 amplitude, and cognition and emotion. Aim 3. By comparing within and between cohorts, evaluate how advancing age and pubertal hormonal development are correlated with structural brain measures of cortical regional gray matter volume, white matter integrity, hippocampal volume, and corpus callosum size. Aim 4. By comparing drinking with non-drinking children in the older cohort, determine the effect sizes of the measured influence of alcohol exposure on our various measures of brain development in mid-adolescence.

描述（由申请人提供）：该提案是对RFA的响应，以评估对酒精暴露对青少年脑发育的影响进行纵向评估的可行性。儿童和青少年在大脑继续发育的时候酗酒是一种重大的健康风险，对发展中神经系统的有害慢性影响被低估了。拟议的研究汇集了敏感，安全和无创的方法，以表征正常青春期期间脑神经生理学和结构完整性的表征，并估计酗酒对发展中大脑的影响。该提案独有的是使用经典睡眠生理学并诱发了脑电图三角洲活动作为发展神经系统的探针，以及它们与脑宏观和微观结构完整性的评估相结合。在青少年中阐明阴险的中枢神经系统对酗酒的影响将使对酒精神经毒性更好地理解可证明的证据以影响青少年行为，并可能为治疗受损的认知，情感和监管行为发展提供有关补偿性和康复性策略的见解。该提案有四个具体的目标：目标1。建立来自大量男孩和女孩的两个小型，道德平衡的样本，以证明评估这些同类群体中酒精和其他物质使用的能力，并遵循一年。第一个将由20名不喝酒的六年级学生组成。第二个将包括10个不喝酒和10名饮酒9年级。 AIM 2。通过比较队列内部和人群之间，评估促进年龄和青春期激素发育与Delta活性的功能性脑测量，N550振幅，增量和N550振幅以及认知和情感的功能相关。 AIM 3。通过比较队列内部和人群之间，评估年龄和青春期荷尔蒙发育与皮质区域灰质体积，白质完整性，海马体积和callosum callosum callosum大小的结构脑测量如何相关。 AIM 4。通过将饮酒与较老的队列中的不饮用的儿童进行比较，确定酒精暴露对我们在青春期中期大脑发育的影响的效果大小。