Alcoholism, Sleep and the Brain

酗酒、睡眠和大脑

• 批准号: 7234832
• 负责人: Ian Michael Colrain
• 金额: $ 55.77万
• 依托单位: SRI INTERNATIONAL
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-06-01 至 2009-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7234832
• 关键词: Acute; Age; Aging; Alcohol consumption; Alcoholism; Alcohols; Anterior; Area; Brain; Characteristics; Chronic; Complex; Drug Metabolic Detoxication; Elderly; Electroencephalography; Event; Evoked Potentials; Generations; Health; Heterogeneity; MRI Scans; Magnetic Resonance Imaging; Measures; Methods; Nervous system structure; Numbers; Pattern; Personal Satisfaction; Physiological; Physiology; Prefrontal Cortex; Production; Property; Psyche structure; REM Sleep; Rate; Relapse; Reporting; Scalp structure; Sex Characteristics; Sleep; Sleep Disorders; Sleep disturbances; Slow-Wave Sleep; Stimulus; Structure; Testing; Thinking; Time; Variant; Woman; chronic alcohol ingestion; gray matter; indexing; men; non rapid eye movement; normal aging; problem drinker; sex; sleep abnormalities; sobriety; voltage

DESCRIPTION (provided by applicant): Acute and chronic alcohol consumption causes sleep disturbances, which may never resolve and may be a key factor in alcoholism relapse. Alcohol-related sleep deficits also become more pronounced with advancing age. The most consistently reported finding of altered sleep in alcoholics is a reduction in spontaneously occurring slow wave sleep (SWS), defined by the presence of delta EEG activity. Further, alcoholics with reduced baseline SWS have an increased likelihood of relapse. External stimulation during sleep can elicit K-complexes, which when averaged produce a large N550 component thought to have the same generator as SWS delta activity. Given the potential value of sleep markers in predicting relapse, it would be advantageous to employ a probe of the sleeping nervous system that can be under experimenter control rather than one that relies on the traditional observation of spontaneous sleep physiological indices. We have demonstrated that sleep-evoked N550 component amplitudes are smaller and K-complexes are produced on a smaller number of trials in elderly than young controls. Our preliminary study indicates that alcoholics have even smaller N550 than would be expected for their age. A candidate generator of the K-complex and N550 is frontal cortical gray matter, which is especially reduced in older alcoholics. Sex differences in brain structure and electrophysiological indices of sleep also occur in alcoholism and aging, and objective study of them may further contribute to our understanding of relevant mechanisms of alcoholism-related sleep disturbance. We propose to test the following hypotheses: Hypothesis 1: Recently detoxified, chronic alcoholics will have smaller N550 amplitudes, lower evoked K-complex proportions, lower SWS levels and delta EEG power compared to sex- and age-matched controls. Hypothesis 2: Low evoked K-complex production rates, small N550 amplitude, low SWS levels and delta EEG power will be associated with small prefrontal gray matter volume. Hypothesis 3: Alcoholic men will have greater sleep abnormalities than alcoholic women. Hypothesis 4: Small amplitude, production rate and power of sleep electrophysiological variables in recently detoxified alcoholics will predict early relapse.

描述（由申请人提供）：急性和慢性饮酒会导致睡眠障碍，这种情况可能永远无法解决，并且可能是酗酒复发的关键因素。随着年龄的增长，与酒精相关的睡眠不足也会变得更加明显。最一致报道的酗酒者睡眠改变是自发发生的慢波睡眠（SWS）的减少，慢波睡眠是由 δ 脑电图活动的存在来定义的。此外，基线 SWS 降低的酗酒者复发的可能性增加。 睡眠期间的外部刺激会引发 K 复合物，平均后会产生大量 N550 成分，被认为与 SWS δ 活动具有相同的发生器。鉴于睡眠标记在预测复发方面的潜在价值，采用一种可以在实验者控制下的睡眠神经系统探针而不是依赖于传统的自发睡眠生理指标观察的探针将是有利的。 我们已经证明，与年轻对照组相比，老年人的睡眠诱发 N550 分量幅度较小，并且在老年人中产生的 K 复合物数量较少。我们的初步研究表明，酗酒者的 N550 甚至比其年龄的预期还要低。 K 复合物和 N550 的候选生成者是额叶皮质灰质，在老年酗酒者中，额叶皮质灰质尤其减少。酒精中毒和衰老也存在大脑结构和睡眠电生理指标的性别差异，对其进行客观研究可能进一步有助于我们了解酒精中毒相关睡眠障碍的相关机制。我们建议检验以下假设： 假设 1：与性别和年龄匹配的对照组相比，最近戒毒的慢性酗酒者将具有较小的 N550 波幅、较低的诱发 K 复合物比例、较低的 SWS 水平和 delta 脑电图功率。 假设 2：低诱发 K 复合物产生率、小 N550 振幅、低 SWS 水平和 Delta EEG 功率将与小前额灰质体积相关。 假设3：酗酒的男性比酗酒的女性有更多的睡眠异常。 假设4：最近戒毒的酗酒者睡眠电生理变量的小幅度、产生率和功效将预测早期复发。

项目成果

K-complexes are not preferentially evoked to combat sounds in combat-exposed Vietnam veterans with and without post-traumatic stress disorder.

• DOI: 10.1016/j.ijpsycho.2011.12.009
• 发表时间: 2012-03
• 期刊: INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY
• 影响因子: 3
• 作者: Franzen, Peter L.;Woodward, Steven H.;Bootzin, Richard R.;Germain, Anne;Colrain, Ian M.
• 通讯作者: Colrain, Ian M.

Sleep evoked delta frequency responses show a linear decline in amplitude across the adult lifespan.

睡眠唤起的三角洲频率反应显示，整个成人寿命的振幅线性下降。

• DOI: 10.1016/j.neurobiolaging.2008.06.003
• 发表时间: 2010-05
• 期刊: NEUROBIOLOGY OF AGING
• 影响因子: 4.2
• 作者: Colrain, Ian M.;Crowley, Kate E.;Nicholas, Christian L.;Afifi, Lamia;Baker, Fiona C.;Padilla, Mayra;Turlington, Sharon R.;Trinder, John
• 通讯作者: Trinder, John

Partial recovery of alcohol dependence-related deficits in sleep evoked potentials following 12 months of abstinence.

• DOI: 10.3389/fneur.2012.00013
• 发表时间: 2012
• 期刊: Frontiers in neurology
• 影响因子: 3.4
• 作者: Colrain IM;Padilla ML;Baker FC
• 通讯作者: Baker FC