General Cognitive /Learning Deficits in Aged Mice

老年小鼠的一般认知/学习缺陷

• 批准号: 6684887
• 负责人: LOUIS D MATZEL
• 金额: $ 7.33万
• 依托单位: RUTGERS, THE STATE UNIV OF N.J.
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-08-01 至 2005-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6684887
• 关键词: age difference; animal old age; behavior test; behavioral /social science research tag; cognition; functional ability; laboratory mouse; learning; male; mature animal; neural information processing; performance; psychological aspect of aging; psychometrics

Animal research on age-related learning deficits has typically focused on the impact of age on specific learning systems. While informative, this work necessarily limits any conclusions regarding the effects of aging on general cognitive/learning abilities. This focus on specific learning systems impacts critically on our understanding of age-related deficits, given that it is estimated that 25-50% of this decline is attributable to an impairment of general cognitive ability, i.e., an ability that transcends specific learning systems or domains. The elucidation of the brain substrates for age-related cognitive deficits thus requires a conceptually-sound approach from which to parse deficits in general abilities from those which impact specific (limited) domains. Absent any attention to general influences on learning/cognitive processes, as much as 50% of decline in cognitive abilities that accrue with aging will necessarily go unexplained, mitigating the development of effective treatment strategies. Among human populations, a general influence on individuals' learning abilities reflects one of the most dominant cognitive traits ever identified. However, comparable evidence from animal subjects is sparse, and age-dependent variations in general learning factors have never been described in laboratory animals. We have recently developed a unique test battery that is sensitive to a general learning factor in mice, and this factor is psychometrically comparable to that described in humans. In Aims 1 and 2 of the present proposal, we summarize our plans to characterize the general learning/cognitive abilities of laboratory mice that range in age from young to old, and describe analysis regimens that will provide preliminary indications of the differential sources of variability that impinge on these abilities across the life span. These studies are a critical prelude to future work directed at the elucidation of the brain substrates for age-related declines in general cognitive/learning abilities.

关于年龄相关学习缺陷的动物研究通常集中在年龄对特定学习系统的影响上。虽然信息丰富，但这项工作必然限制了关于衰老对一般认知/学习能力影响的任何结论。这种对特定学习系统的关注严重影响了我们对年龄相关缺陷的理解，因为据估计，这种下降的25-50%可归因于一般认知能力的损害，即，超越特定学习系统或领域的能力。因此，阐明与年龄相关的认知缺陷的大脑基质需要一种概念上合理的方法，从这种方法中解析影响特定（有限）领域的一般能力缺陷。如果不注意对学习/认知过程的一般影响，那么随着年龄的增长，多达50%的认知能力下降将 不可避免地无法解释，从而阻碍了有效治疗策略的发展。 在人类群体中，对个人学习能力的普遍影响反映了有史以来最主要的认知特征之一。然而，来自动物受试者的类似证据很少，并且在实验室动物中从未描述过一般学习因素的年龄依赖性变化。我们最近开发了一种独特的测试电池，对小鼠的一般学习因素敏感，并且该因素在心理测量上与人类中描述的因素相当。在本提案的目标1和2中，我们总结了我们表征从年轻到年老的实验室小鼠的一般学习/认知能力的计划，并描述了将提供实验室小鼠的一般学习/认知能力的初步指示的分析方案。 不同的变异性来源会在整个生命周期中影响这些能力。这些研究是未来工作的重要前奏，旨在阐明与年龄相关的一般认知/学习能力下降的大脑基质。

项目成果

The causes of variation in learning and behavior: why individual differences matter.

学习和行为差异的原因：为什么个体差异很重要。

• DOI: 10.3389/fpsyg.2013.00395
• 发表时间: 2013
• 期刊: Frontiers in psychology
• 影响因子: 3.8
• 作者: Sauce B;Matzel LD
• 通讯作者: Matzel LD

A broader phenotype of persistence emerges from individual differences in response to extinction.

• DOI: 10.3758/s13423-017-1402-9
• 发表时间: 2018-10
• 期刊: Psychonomic bulletin & review
• 影响因子: 3.5
• 作者: Sauce B;Wass C;Lewis M;Matzel LD
• 通讯作者: Matzel LD

Dopamine D1 sensitivity in the prefrontal cortex predicts general cognitive abilities and is modulated by working memory training.

• DOI: 10.1101/lm.031971.113
• 发表时间: 2013-10-15
• 期刊: Learning & memory (Cold Spring Harbor, N.Y.)
• 作者: Wass C;Pizzo A;Sauce B;Kawasumi Y;Sturzoiu T;Ree F;Otto T;Matzel LD
• 通讯作者: Matzel LD

Covariation of learning and "reasoning" abilities in mice: evolutionary conservation of the operations of intelligence.

小鼠学习和“推理”能力的协变：智力运作的进化守恒。

• DOI: 10.1037/a0027355
• 发表时间: 2012
• 期刊: Journal of experimental psychology. Animal behavior processes
• 作者: Wass,Christopher;Denman-Brice,Alexander;Rios,Chris;Light,KennethR;Kolata,Stefan;Smith,AndrewM;Matzel,LouisD
• 通讯作者: Matzel,LouisD