Mechanisms of Novel TLR9 mediated intraocular inflammation

新型TLR9介导的眼内炎症机制

• 批准号: nhmrc : 1026301
• 负责人: Prof John Forrester
• 金额: $ 29.49万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/mechanisms-novel-tlr9-intraocular-inflammation/110485
• 关键词: Mechanisms; Novel; TLR9; mediated; intraocular

Corneal opacities and scarring due to microbial and parasitic infections are a major cause of blindness globally. Novel studies in our lab have shown that topical application of bacterial/viral DNA alone to the cornea can cause previously unrecognised inflammation in the retina. Understanding the mechanisms of this retinal inflammation and how to block it may help in the design of novel treatments for a number of blinding conditions.

由微生物和寄生虫感染引起的角膜混浊和瘢痕是全球失明的主要原因。我们实验室的新研究表明，将细菌/病毒DNA单独局部应用于角膜可能会导致视网膜中先前未被识别的炎症。了解这种视网膜炎症的机制以及如何阻止它可能有助于设计一些致盲条件的新治疗方法。